Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene.

cancer; ptereostilbene; resveratrol; signaling pathways; stem cells; Antineoplastic Agents, Phytogenic; Neoplasm Proteins; Stilbenes; pterostilbene; Resveratrol; Animals; Antineoplastic Agents, Phytogenic/pharmacology; Apoptosis/drug effects; Breast Neoplasms/drug therapy; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Carcinogenesis/drug effects; Carcinogenesis/genetics; Carcinogenesis/metabolism; Carcinogenesis/pathology; Cell Communication/drug effects; Cell Line, Tumor; Female; Humans; Mice; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; Neoplastic Stem Cells/drug effects; Neoplastic Stem Cells/metabolism; Neoplastic Stem Cells/pathology; Signal Transduction; Stilbenes/pharmacology; Xenograft Model Antitumor Assays; Gene Expression Regulation, Neoplastic; Apoptosis; Breast Neoplasms; Carcinogenesis; Cell Communication; Neoplastic Stem Cells; Biochemistry; Molecular Medicine; Clinical Biochemistry; General Medicine

Abstract :

[en] In past decades, increasing evidence regarding cancer stem cells (CSCs) may account for carcinogenesis, tumor drug-resistant, and metastasis. CSCs are even considered as the root causes of tumor recurrence and metastases. Targeting CSCs may provide a new clue to cure cancer. Epidemiological and clinical studies have suggested that intake of dietary natural products may bring health benefits including lowering risk of cancer incidence. In this review, we have particularly focused on targeting signaling pathways of CSCs by natural resveratrol and its dimethylated derivative pterostilbene. © 2017 BioFactors, 44(1):61-68, 2018.

Disciplines :

Food science

Author, co-author :

Zhang, Lingling; Tianjin Key Laboratory of Food and Biotechnology, Food Science Division, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China ; Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources, Food Science Division, Huanggang Normal University, Huanggang, Hubei, China ; Department of Pharmacology and Toxicology, National Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute of Planned Parenthood Research, Shanghai, China ; Key Laboratory of Reproduction Regulation of NPFPC of Shanghai, Food Science Division, Reproductive and Developmental Research Institute of Fudan University, Shanghai, China

Wen, Xiang ; Université de Liège - ULiège > GIGA > GIGA Stem Cells - Medical Chemistry ; Tianjin Key Laboratory of Food and Biotechnology, Food Science Division, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China

Li, Mengmeng; Tianjin Key Laboratory of Food and Biotechnology, Food Science Division, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China

Li, Shiming ; Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources, Food Science Division, Huanggang Normal University, Huanggang, Hubei, China

Zhao, Hui; Tianjin Key Laboratory of Food and Biotechnology, Food Science Division, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China

Language :

English

Title :

Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene.

Publication date :

January 2018

Journal title :

BioFactors (Oxford, England)

ISSN :

0951-6433

eISSN :

1872-8081

Publisher :

Blackwell Publishing Inc., Netherlands

Volume :

Issue :

Pages :

61 - 68

Peer reviewed :

Peer reviewed

Additional URL :

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiof.1398

Funders :

NSCF - National Natural Science Foundation of China

Funding text :

This study received the support of the National Natural Science Foundation of China (31571832).

Available on ORBi :

since 09 April 2024

Statistics

Number of views

22 (0 by ULiège)

Number of downloads

44 (0 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Siegel, R. L., Miller, K. D., and Jemal, A. (2017) Cancer statistics, 2017. CA: A Cancer J. Clin. 67, 7–30.
Hanahan, D., and Weinberg, R. A. (2011) Hallmarks of cancer: the next generation. Cell 144, 646–674.
Lobo, N. A., Shimono, Y., Qian, D., and Clarke, M. F. (2007) The biology of cancer stem cells. Annu. Rev. Cell Dev. Biol. 23, 675–699.
Peitzsch, C., Tyutyunnykova, A., Pantel, K., and Dubrovska, A. (2017) Cancer stem cells: the root of tumor recurrence and metastasis. Semin. Cancer Biol. 44, 10–12.
Key, T. J. (2011) Fruit and vegetables and cancer risk. Br. J. Cancer, 104, 6–11.
Thomas, R., Butler, E., Macchi, F., and Williams, M. (2015) Phytochemicals in cancer prevention and management? Br. J. Med. Pract. 8, 22–28.
Singh, A. K., Sharma, N., Ghosh, M., Park, Y. H., and Jeong, D. K. (2017) Emerging importance of dietary phytochemicals in fight against cancer: role in targeting cancer stem cells. Crit. Rev. Food Sci. Nutr. 57, 3449–3463.
Shanmugam, M. K., Lee, J. H., Chai, E. Z. P., Kanchi, M. M., Kar, S., et al. (2016) Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds. Semin. Cancer Biol., 40–41, 35–47.
Bonnet, D., and Dick, J. E. (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3, 730–737.
Wainwright, E. N., and Scaffidi, P. (2017) Epigenetics and cancer stem cells: unleashing, hijacking, and restricting cellular plasticity. Trends Cancer, 3, 372–386.
Kharkar, P. S. (2017) Cancer stem cell (csc) inhibitors: a review of recent patents (2012–2015). Expert Opin. Ther. Pat. 27, 753–761.
Reddivari, L., Charepalli, V., Radhakrishnan, S., Vadde, R., Elias, R. J., et al. (2016) Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis. BMC Complement Altern. Med. 16, 278.
Meng, D., Zhang, P., Zhang, L., Wang, H., Ho, C.-T., et al. (2017) Detection of cellular redox reactions and antioxidant activity assays. J. Funct. Foods 37, 467–479.
Langcake, P., and Pryce, R. J. (1977) A new class of phytoalexins from grapevines. Experientia 33, 151–152.
Chang, G., Xiao, W., Xu, Z., Yu, D., Li, B., et al. (2017) Pterostilbene induces cell apoptosis and cell cycle arrest in t-cell leukemia/lymphoma by suppressing the erk1/2 pathway. Biomed. Res. Int. 2017, 9872073.
Pan, M. H., Chang, Y. H., Badmaev, V., Nagabhushanam, K., and Ho, C.-T. (2007) Pterostilbene induces apoptosis and cell cycle arrest in human gastric carcinoma cells. J. Agric. Food Chem. 55, 7777–7785.
Wang, L., Wang, J., Fang, L., Zheng, Z., Zhi, D., et al. (2014) Anticancer activities of citrus peel polymethoxyflavones related to angiogenesis and others. Biomed. Res. Int. 2014, 453972.
Fu, Y., Chang, H., Peng, X., Bai, Q., Yi, L., et al. (2014) Resveratrol inhibits breast cancer stem-like cells and induces autophagy via suppressing wnt/Î2-catenin signaling pathway. PLoS One 9, e102535.
Pandey, P. R., Okuda, H., Watabe, M., Pai, S. K., Liu, W., et al. (2011) Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase. Breast Cancer Res. Treat. 130, 387–398.
Hagiwara, K., Kosaka, N., Yoshioka, Y., Takahashi, R., Takeshita, F., et al. (2012) Stilbene derivatives promote ago2-dependent tumour-suppressive microrna activity. Sci. Rep. 2, 314.
Choi, Y. J., Heo, K., Park, H. S., Yang, K. M., and Jeong, M. H. (2016) The resveratrol analog hs-1793 enhances radiosensitivity of mouse-derived breast cancer cells under hypoxic conditions. Int. J. Oncol. 49, 1479.
Mak, K. K., Wu, A. T., Lee, W. H., Chang, T. C., Chiou, J. F., et al. (2013) Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating nf-κb/microrna 448 circuit. Mol. Nutr. Food Res. 57, 1123–1134.
Hu, L., Cao, D., Li, Y., He, Y., and Guo, K. (2012) Resveratrol sensitized leukemia stem cell-like kg-1a cells to cytokine-induced killer cells-mediated cytolysis through nkg2d ligands and trail receptors. Cancer Biol. Ther. 13, 516–526.
Su, Y. C., Li, S. C., Wu, Y. C., Wang, L. M., Chao, K. S., et al. (2013) Resveratrol downregulates interleukin-6-stimulated sonic hedgehog signaling in human acute myeloid leukemia. Evid. Based Complement Alternat. Med. 2013, 221–229.
Sayd, S., Thirant, C., Elhabr, E. A., Lipecka, J., Dubois, L. G., et al. (2014) Sirtuin-2 activity is required for glioma stem cell proliferation arrest but not necrosis induced by resveratrol. Stem Cell Rev. 10, 103–113.
Wang, L., Long, L., Wang, W., and Liang, Z. (2015) Resveratrol, a potential radiation sensitizer for glioma stem cells both in vitro and in vivo. J. Pharmacol. Sci. 129, 216–225.
Cilibrasi, C., Riva, G., Romano, G., Cadamuro, M., Bazzoni, R., et al. (2017) Resveratrol impairs glioma stem cells proliferation and motility by modulating the wnt signaling pathway. PLoS One 12, e0169854.
Huynh, T. T., Lin, C. M., Lee, W. H., Wu, A. T., Lin, Y. K., et al. (2015) Pterostilbene suppressed irradiation-resistant glioma stem cells by modulating grp78/mir-205 axis. J. Nutr. Biochem. 26, 466–475.
Hu, F. W., Tsai, L. L., Yu, C. H., Chen, P. N., Chou, M. Y., et al. (2012) Impairment of tumor-initiating stem-like property and reversal of epithelial-mesenchymal transdifferentiation in head and neck cancer by resveratrol treatment. Mol. Nutr. Food Res. 56, 1247–1258.
Hardin, H., Yu, X. M., Harrison, A. D., Larrain, C., Zhang, R., et al. (2016) Generation of novel thyroid cancer stem-like cell clones: effects of resveratrol and valproic acid. Am. J. Pathol. 186, 1662–1673.
Seino, M., Okada, M., Shibuya, K., Seino, S., Suzuki, S., et al. (2015) Differential contribution of ros to resveratrol-induced cell death and loss of self-renewal capacity of ovarian cancer stem cells. Anticancer Res. 35, 85–96.
Shen, Y. A., Lin, C. H., Chi, W. H., Wang, C. Y., Hsieh, Y. T., et al. (2013) Resveratrol impedes the stemness, epithelial-mesenchymal transition, and metabolic reprogramming of cancer stem cells in nasopharyngeal carcinoma through p53 activation. Evid. Based Complement Alternat. Med. 2013, 590393.
Chen, Y. J., Chen, Y. Y., Lin, Y. F., Hu, H. Y., and Liao, H. F. (2013) Resveratrol inhibits alpha-melanocyte-stimulating hormone signaling, viability, and invasiveness in melanoma cells. Evid. Based Complement Alternat. Med. 2013, 632121.
Lee, C. M., Su, Y. H., Huynh, T. T., Lee, W. H., Chiou, J. F., et al. (2013) Blueberry isolate, pterostilbene, functions as a potential anticancer stem cell agent in suppressing irradiation-mediated enrichment of hepatoma stem cells. Evid. Based Complement Alternat. Med. 2013, 258425.
Huang, W. C., Chan, M. L., Chen, M. J., Tsai, T. H., and Chen, Y. J. (2016) Modulation of macrophage polarization and lung cancer cell stemness by muc1 and development of a related small-molecule inhibitor pterostilbene. Oncotarget 7, 39363.
Dandawate, P. R., Subramaniam, D., Jensen, R. A., and Anant, S. (2016) Targeting cancer stem cells and signaling pathways by phytochemicals: novel approach for breast cancer therapy. Semin. Cancer Biol. 40–41, 192–208.
Dewangan, J., Tandon, D., Srivastava, S., Verma, A. K., Yapuri, A., et al. (2017). Novel combination of salinomycin and resveratrol synergistically enhances the anti-proliferative and pro-apoptotic effects on human breast cancer cells. Apoptosis, 22, 1246–1259.
Debnath, T., Nath, N. C. D., Kim, E. K., and Lee, K. G. (2017) Role of phytochemicals in the modulation of mirna expression in cancer. Food Funct. 8, 3432–3442.
Wu, C. H., Hong, B. H., Ho, C. T., and Yen, G. C. (2015) Targeting cancer stem cells in breast cancer: potential anticancer properties of 6-shogaol and pterostilbene. J. Agric. Food Chem., 63, 2432–2441.
Bahr, C., Correia, N. C., and Trumpp, A. (2017) Stem cells make leukemia grow again. EMBO J. e201797773.
Memmi, E. M., Sanarico, A. G., Giacobbe, A., Peschiaroli, A., Frezza, V., et al. (2015) P63 sustains self-renewal of mammary cancer stem cells through regulation of sonic hedgehog signaling. Proc. Natl. Acad. Sci. USA 112, 3499–3504.
Crews, L. A., and Jamieson, C. H. (2013) Selective elimination of leukemia stem cells: hitting a moving target. Cancer Lett. 338, 15–22.
Lu, F. L., Yu, C. C., Chiu, H. H., Liu, H. E., Chen, S. Y., et al. (2013) Sonic hedgehog antagonists induce cell death in acute myeloid leukemia cells with the presence of lipopolysaccharides, tumor necrosis factor-α, or interferons. Invest. New Drugs, 31, 823–832.
Shet, A. S., Jahagirdar, B. N., and Verfaillie, C. M. (2002) Chronic myelogenous leukemia: mechanisms underlying disease progression. Leukemia, 16, 1402–1411.
Tolomeo, M., Grimaudo, S., Di, C. A., Roberti, M., Pizzirani, D., et al. (2005) Pterostilbene and 3'-hydroxypterostilbene are effective apoptosis-inducing agents in mdr and bcr-abl-expressing leukemia cells. Int. J. Biochem. Cell Biol. 37, 1709–1726.
Khalek, F. J. A., Gallicano, G. I., and Mishra, L. (2010) Colon cancer stem cells. Gastrointest. Cancer Res. (Suppl 1), S16.
Markowitz, S. D., and Bertagnolli, M. M. (2009) Molecular origins of cancer: molecular basis of colorectal cancer. N. Engl. J. Med. 361, 2449–2460.
Yu, X. M., Jaskula-Sztul, R., Ahmed, K., Harrison, A. D., Kunnimalaiyaan, M., and Chen, H. (2013) Resveratrol induces differentiation markers expression in anaplastic thyroid carcinoma via activation of notch1 signaling and suppresses cell growth. Mol. Cancer Ther. 12, 1276–1287.
Poveda, A., Ray-Coquard, I., Romero, I., Lopez-Guerrero, J. A., and Colombo, N. (2014) Emerging treatment strategies in recurrent platinum-sensitive ovarian cancer: focus on trabectedin. Cancer Treat. Rev. 40, 366–375.