Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene.

cancer; ptereostilbene; resveratrol; signaling pathways; stem cells; Antineoplastic Agents, Phytogenic; Neoplasm Proteins; Stilbenes; pterostilbene; Resveratrol; Animals; Antineoplastic Agents, Phytogenic/pharmacology; Apoptosis/drug effects; Breast Neoplasms/drug therapy; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Carcinogenesis/drug effects; Carcinogenesis/genetics; Carcinogenesis/metabolism; Carcinogenesis/pathology; Cell Communication/drug effects; Cell Line, Tumor; Female; Humans; Mice; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; Neoplastic Stem Cells/drug effects; Neoplastic Stem Cells/metabolism; Neoplastic Stem Cells/pathology; Signal Transduction; Stilbenes/pharmacology; Xenograft Model Antitumor Assays; Gene Expression Regulation, Neoplastic; Apoptosis; Breast Neoplasms; Carcinogenesis; Cell Communication; Neoplastic Stem Cells; Biochemistry; Molecular Medicine; Clinical Biochemistry; General Medicine

Abstract :

[en] In past decades, increasing evidence regarding cancer stem cells (CSCs) may account for carcinogenesis, tumor drug-resistant, and metastasis. CSCs are even considered as the root causes of tumor recurrence and metastases. Targeting CSCs may provide a new clue to cure cancer. Epidemiological and clinical studies have suggested that intake of dietary natural products may bring health benefits including lowering risk of cancer incidence. In this review, we have particularly focused on targeting signaling pathways of CSCs by natural resveratrol and its dimethylated derivative pterostilbene. © 2017 BioFactors, 44(1):61-68, 2018.

Disciplines :

Food science

Author, co-author :

Zhang, Lingling; Tianjin Key Laboratory of Food and Biotechnology, Food Science Division, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China ; Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources, Food Science Division, Huanggang Normal University, Huanggang, Hubei, China ; Department of Pharmacology and Toxicology, National Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute of Planned Parenthood Research, Shanghai, China ; Key Laboratory of Reproduction Regulation of NPFPC of Shanghai, Food Science Division, Reproductive and Developmental Research Institute of Fudan University, Shanghai, China

Wen, Xiang ; Université de Liège - ULiège > GIGA > GIGA Stem Cells - Medical Chemistry ; Tianjin Key Laboratory of Food and Biotechnology, Food Science Division, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China

Li, Mengmeng; Tianjin Key Laboratory of Food and Biotechnology, Food Science Division, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China

Li, Shiming ; Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources, Food Science Division, Huanggang Normal University, Huanggang, Hubei, China

Zhao, Hui; Tianjin Key Laboratory of Food and Biotechnology, Food Science Division, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China

Language :

English

Title :

Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene.

Publication date :

January 2018

Journal title :

BioFactors (Oxford, England)

ISSN :

0951-6433

eISSN :

1872-8081

Publisher :

Blackwell Publishing Inc., Netherlands

Volume :

Issue :

Pages :

61 - 68

Peer reviewed :

Peer reviewed

Additional URL :

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiof.1398

Funders :

NSCF - National Natural Science Foundation of China [CN]

Funding text :

This study received the support of the National Natural Science Foundation of China (31571832).

Available on ORBi :

since 09 April 2024

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