[en] The intestinal barrier plays a central role in sustaining gut homeostasis and, when dysfunctional, may contribute to diseases. Dietary flavonoids derived from Citrus genus represent one of the main naturally occurring phytochemicals with multiple potential benefits for the intestinal barrier function. In the intestine, citrus flavonoids (CFs) undergo ingestion from the lumen, biotransformation in the epithelial cells and/or crosstalk with luminal microbiota to afford various metabolites that may in turn exert protective actions on gut barrier along with their parental compounds. Specifically, the health-promoting properties of CFs and their metabolic bioactives for the intestinal barrier include their capacity to (a) modulate barrier permeability; (b) protect mucus layer; (c) regulate intestinal immune system; (d) fight against oxidative stress; and (e) positively shape microbiome and metabolome. Notably, local effects of CFs can also generate systemic benefits, for instance, improvement of gut microbial dysbiosis helpful to orchestrate gut homeostasis and leading to alleviation of systemic dysmetabolism. Given the important role of the intestinal barrier in overall health, further understanding of underlying action mechanisms and ultimate health effects of CFs as well as their metabolites on the intestine is of great significance to future application of citrus plants and their bioactives as dietary supplements and/or functional ingredients in medical foods.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Wang, Meiyan ; Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China
Zhao, Hui; Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China
Wen, Xiang ; Université de Liège - ULiège > GIGA > GIGA Stem Cells - Medical Chemistry ; Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China ; Hubei Key Laboratory for EFGIR, Huanggang Normal University, Hubei, China
Ho, Chi-Tang; Department of Food Science, Rutgers University, New Brunswick, New Jersey
Li, Shiming; Hubei Key Laboratory for EFGIR, Huanggang Normal University, Hubei, China ; Department of Food Science, Rutgers University, New Brunswick, New Jersey
Language :
English
Title :
Citrus flavonoids and the intestinal barrier: Interactions and effects.
Publication date :
January 2021
Journal title :
Comprehensive Reviews in Food Science and Food Safety
NSCF - National Natural Science Foundation of China
Funding text :
This work was financially supported by the National Natural
Science Foundation of China (Grant No. 81803548),
Tianjin Innovative Research Team Grant (TD13-5087),
Hubei Province Technical Innovation Special Project
(2019ABA100), and Natural Science Foundation of Tianjin
(19JCQNJC12400).
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