Similar efficacy outcomes with peripheral blood stem cell versus bone marrow for autologous stem cell transplantation in acute myeloid leukemia: Long-term follow-up of the EORTC-GIMEMA randomized AML-10 trial.
[en] We report here the long-term follow-up of the only prospective randomized trial of autologous hematopoietic stem cell transplantation (auto-HSCT) with peripheral blood stem cells (APBSCT) versus auto-HSCT with bone marrow (ABMT) in acute myeloid leukemia (AML) patients in first remission (CR). We observed that among patients alive and still in CR 5 years after planned auto-HSCT, approximately 10% of the patients died in the following 10 years. This stresses the need for long-term close surveillance of AML patients after auto-HSCT. Further, long-term follow-up of the trial confirms that APBSCT was comparable to ABMT in term of disease-free-survival and overall survival.
Disciplines :
Hematology
Author, co-author :
Baron, Frédéric ; Université de Liège - ULiège > Département des sciences cliniques
Efficace, Fabio ; Gruppo Italiano Malattie Ematologiche Dell'Adulto GIMEMA, Rome, Italy
Cannella, Laura; Gruppo Italiano Malattie Ematologiche Dell'Adulto GIMEMA, Rome, Italy
Stevens-Kroef, Marian; Radboud University Medical Center, Nijmegen, The Netherlands
Amadori, Sergio; Gruppo Italiano Malattie Ematologiche Dell'Adulto GIMEMA, Rome, Italy
de Witte, Theo; Radboud University Medical Center, Nijmegen, The Netherlands
Lübbert, Michael; Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany
Venditti, Adriano ; Department of Hematology, Sapienza University, Rome, Italy
Similar efficacy outcomes with peripheral blood stem cell versus bone marrow for autologous stem cell transplantation in acute myeloid leukemia: Long-term follow-up of the EORTC-GIMEMA randomized AML-10 trial.
The authors thank all the EORTC Leukemia Group and GIMEMA members and the clinicians who participated in this study. This publication was supported by a donation from the “Fondation contre le cancer” from Belgium. FB is a senior research associate of the Fund for Scientific Research (FRS‐FNRS) Belgium.
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