Aging; Blind mole-rat; Cardiovascular Diseases; Cellular senescence; Microchip; Naked mole-rat; Organoid; Senotherapeutics; Genetics; Molecular Biology; Physiology; General Medicine
Abstract :
[en] Increasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related pathologies. During the aging process, senescent cell accumulation results in senescence-associated secretory phenotype (SASP) which plays an essential role in tissue dysfunction. Although discovered very recently, senotherapeutic drugs have been already involved in clinical studies. This review gives a summary of the molecular mechanisms of CS and its role particularly in the development of cardiovascular diseases (CVD) as the leading cause of death. In addition, it addresses alternative research tools including the nonhuman and human models as well as computational techniques for the discovery of novel therapies. Finally, senotherapeutic approaches that are mainly classified as senolytics and senomorphics are discussed.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Inci Kavum, Nurcan ✱; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Pharmacologie
Kamali, Dilanur ✱; Graduate School of Natural and Applied Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
Akyildiz, Erdogan Oguzhan; Graduate School of Natural and Applied Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
Tahir Turanli, Eda; Graduate School of Natural and Applied Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey ; Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
Bozaykut, Perinur; Graduate School of Natural and Applied Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey ; Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
✱ These authors have contributed equally to this work.
Language :
English
Title :
Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models.
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