Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation.
Chondroitin sulfate; Clinical efficacy; Fish cartilage hydrolysate; Joint discomfort; Nutraceuticals; Pain; Aged; Humans; Adult; Animals; Rats; Knee Joint; Cartilage; Dietary Supplements; Quality of Life; Osteoarthritis; Rheumatology; Orthopedics and Sports Medicine
Abstract :
[en] [en] BACKGROUND: Aging is frequently associated with impairments of the musculoskeletal system and many elderly people experience joint discomfort or pain which might reduce their ability to move and consequently alter their quality of life. A beneficial effect of fish cartilage hydrolysate (FCH) on pain and joint function has recently been shown in an ACLT/pMMx osteoarthritis rat model.
METHODS: We therefore performed an exploratory, non-comparative, multi-centric clinical trial including 33 subjects with moderate knee joint discomfort and loss of functionality to investigate the efficacy of FCH on their algo-functional status. We further determined the potential health benefit of FCH in an original clinical ex vivo study investigating the role of FCH human metabolites on primary human chondrocytes.
RESULTS: FCH significantly improved knee pain and function, as assessed by the Knee injury and Osteoarthritis Outcome Score (KOOS). Moreover, FCH significantly reduced pain at rest and while walking, and patient global assessment (PGA), as assessed by the Visual Analogue Scale (VAS), and improved patients' quality of life (SF-36). FCH metabolites decreased the synthesis of catabolic factors (MMP-13) and pro-inflammatory mediators (NO, PGE2) and limited the inhibitory effect of IL-1β on the synthesis of cartilage matrix components (GAG and collagen).
CONCLUSIONS: Thus, these data provide insights on the mode of action of FCH in humans and contribute to explain how FCH may relieve pain and improve joint function in subjects with knee discomfort. Although these preliminary data need to be confirmed in a randomized controlled trial, they strongly support the potential health benefit of such an active ingredient.
TRIAL REGISTRATION: The study was registered on clinicaltrials.gov with the identifier NCT04420091 (09/06/2020).
Disciplines :
Rheumatology
Author, co-author :
Henrotin, Yves ; Université de Liège - ULiège > Département des Sciences de l'activité physique et de la réadaptation > Pathologie générale et physiopathologie - Techniques particulières de kinésithérapie
Herman, Julie ; Université de Liège - ULiège > Centres généraux > Centre d'ingénierie des protéines ; Artialis SA, Avenue de l'Hôpital 11, Liège, 4000, Belgium
Uebelhoer, Melanie; Artialis SA, Avenue de l'Hôpital 11, Liège, 4000, Belgium
Wauquier, Fabien; Clinic'n'Cell SAS, UFR de Médecine et de Pharmacie, 28 Place Henri Dunant, Clermont-Ferrand, TSA, 50400 63001, France
Boutin-Wittrant, Line; Clinic'n'Cell SAS, UFR de Médecine et de Pharmacie, 28 Place Henri Dunant, Clermont-Ferrand, TSA, 50400 63001, France
Donneau, Anne-Françoise ; Université de Liège - ULiège > Département des sciences de la santé publique
Monseur, Justine ; Université de Liège - ULiège > Département des sciences de la santé publique > Biostatistique
Fotso, Variance Mokam; Artialis SA, Avenue de l'Hôpital 11, Liège, 4000, Belgium
Wagner, Mélanie; Centre Médical Chant d'oiseau, Avenue des Frères Legrain 85, Woluwe-Saint Pierre, 1150, Belgium
Bouvret, Elodie; Abyss Ingredients, 860 Route de Caudan, Caudan, 56850, France
Costes, Bérénice ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Immunologie vétérinaire ; Artialis SA, Avenue de l'Hôpital 11, Liège, 4000, Belgium
Wittrant, Yohann; INRAE, UNH, Clermont-Ferrand, 63001, France ; Université Clermont Auvergne, UFR de Médecine de de Pharmacie, 28 Place Henri Dunant, Clermont-Ferrand, TSA, 50400 63001, France
Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation.
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