[en] Polyurethanes (PUs) have adjustable mechanical properties, making them suitable for a wide range of applications, including in the biomedical field. Historically, these PUs have been synthesized from isocyanates, which are toxic compounds to handle. This has encouraged the search for safer and more environmentally friendly synthetic routes, leading today to the production of nonisocyanate polyurethanes (NIPUs). Among these NIPUs, polyhydroxyurethanes (PHUs) bear additional hydroxyl groups, which are particularly attractive for derivatizing and adjusting their physicochemical properties. In this paper, polyether-based NIPU elastomers with variable stiffness are designed by functionalizing the hydroxyl groups of a poly(propylene glycol)-PHU by a cyclic carbonate carrying a pendant unsaturation, enabling them to be post-photo-cross-linked with polythiols (thiol-ene). Elastomers with remarkable mechanical properties whose stiffness can be adjusted are obtained. Thanks to the unique viscous properties of these PHU derivatives and their short gel times observed by rheology experiments, formulations for light-based three-dimensional (3D) printing have been developed. Objects were 3D-printed by digital light processing with a resolution down to the micrometer scale, demonstrating their ability to target various designs of prime importance for personalized medicine. In vitro biocompatibility tests have confirmed the noncytotoxicity of these materials for human fibroblasts. In vitro hemocompatibility tests have revealed that they do not induce hemolytic effects, they do not increase platelet adhesion, nor activate coagulation, demonstrating their potential for future applications in the cardiovascular field.
Research Center/Unit :
CERM - Center for Education and Research on Macromolecules - ULiège CESAM - Complex and Entangled Systems from Atoms to Materials - ULiège GIGA - Cardiology - ULiège
Disciplines :
Materials science & engineering Chemistry
Author, co-author :
Pierrard, Anna ; University of Liège [ULiège] - Complex and Entangled Systems from Atoms to Materials [CESAM] Research Unit - Center for Education and Research on Macromolecules [CERM] - Belgium
Thijssen, Quinten ; University of Gent [UGent] - Centre of Macromolecular Chemistry - Polymer Chemistry and Biomaterials Group - Belgium
Van Vlierberghe, Sandra ; University of Gent [UGent] - Centre of Macromolecular Chemistry - Polymer Chemistry and Biomaterials Group - Belgium
Lancellotti, Patrizio ; University of Liège [ULiège] - GIGA - Cardiology - Belgium ; University Hospital Center [CHU] - Liège - Belgium
Oury, Cécile ; University of Liège [ULiège] - GIGA - Cardiology - Belgium
Detrembleur, Christophe ; University of Liège [ULiège] - Complex and Entangled Systems from Atoms to Materials [CESAM] Research Unit - Center for Education and Research on Macromolecules [CERM] - Belgium
Jérôme, Christine ; University of Liège [ULiège] - Complex and Entangled Systems from Atoms to Materials [CESAM] Research Unit - Center for Education and Research on Macromolecules [CERM] - Belgium
Language :
English
Title :
Design of 3D-Photoprintable, Bio-, and Hemocompatible Nonisocyanate Polyurethane Elastomers for Biomedical Implants.
Publication date :
11 March 2024
Journal title :
Biomacromolecules
ISSN :
1525-7797
eISSN :
1526-4602
Publisher :
American Chemical Society (ACS), United States
Volume :
25
Issue :
3
Pages :
1810-1824
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
The "CO2SWITCH" project
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique FWO - Research Foundation Flanders FRIA - Fund for Research Training in Industry and Agriculture Leon Fredericq Foundation
Funding text :
The authors would like to acknowledge the funding from “Fonds Wetenschappelijk Onderzoek” FWO (FWO-SB fellow - 1SA2321N) and the “Fonds de la Recherche Scientifique” F.R.S.-FNRS in the frame of the FRIA grant of S. F. Melo and the Research Director positions of C.D. and C.O.. S. F. Melo obtained additional financial support from the GIGA Doctoral School for Health Sciences and the “Fondation Léon Frédéricq”. C.D. thanks FNRS for financing the CO2Switch project (convention T.0075.20).
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