[en] [en] OBJECTIVE: To develop and validate the Reflux Sign Assessment (RSA), a clinical instrument evaluating the physical findings of laryngopharyngeal reflux (LPR).
METHODS: A total of 106 patients completed a 3-month treatment based on the association of diet, pantoprazole, alginate, or magaldrate with the LPR characteristics (acid, nonacid, mixed). Forty-two asymptomatic individuals completed the study (control group). The RSA results and reflux finding score (RFS) were documented for the LPR patients at baseline and after treatment. Intrarater reliability was assessed through a test-retest blinded evaluation of signs (7-day intervals). Interrater reliability was assessed by comparing the RSA evaluations of three blinded otolaryngologists through Kendall's W. Responsiveness to change was evaluated through a comparison of the baseline and 3-month posttreatment findings. The RSA cutoffs for determining the presence and absence of LPR were examined by receiver operating characteristic (ROC) analysis.
RESULTS: A total of 102 LPR patients completed the study (68 females). The mean age was 53 years. The mean RSA at baseline was 25.95 ± 9.58; it significantly improved to 18.96 ± 7.58 after 3 months of therapy (P < .001). RSA exhibited good intra- (r = 0.813) and interrater (Kendall's W = 0.663) reliabilities (N = 56). There was no significant association between the RSA, gastrointestinal endoscopy findings, and the types of reflux (acid, nonacid, or mixed) according to impedance-pH monitoring. An RSA >14 may be suggestive of LPR.
CONCLUSION: The RSA is a complete clinical instrument evaluating both laryngeal and extralaryngeal findings associated with LPR. The RSA demonstrated high intra- and interrater reliabilities and responsiveness to change.
Disciplines :
Otolaryngology
Author, co-author :
Lechien, Jérôme R ; Research Committee of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS ; Laboratory of Anatomy and Cell Biology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium ; Department of Otorhinolaryngology and Head and Neck Surgery, CHU Saint-Pierre, Brussels, Belgium ; Laboratory of Phonetics, Faculty of Psychology, Research Institute for Language sciences and Technology, University of Mons (UMons), Mons, Belgium
Rodriguez Ruiz, Alexandra; Research Committee of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS ; Department of Otorhinolaryngology and Head and Neck Surgery, CHU Saint-Pierre, Brussels, Belgium
Dequanter, Didier; Research Committee of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS ; Department of Otorhinolaryngology and Head and Neck Surgery, CHU Saint-Pierre, Brussels, Belgium
Bobin, Francois; Research Committee of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS ; Department of Otorhinolaryngology and Head and Neck Surgery, Elsan Polyclinique de Poitiers, France
Mouawad, Francois; Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Lille, Lille, France
Muls, Vinciane; Research Committee of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS ; Department of Gastroenterology and Endoscopy, CHU Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium
Huet, Kathy ; Research Committee of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS ; Laboratory of Phonetics, Faculty of Psychology, Research Institute for Language sciences and Technology, University of Mons (UMons), Mons, Belgium
Harmegnies, Bernard; Research Committee of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS ; Laboratory of Phonetics, Faculty of Psychology, Research Institute for Language sciences and Technology, University of Mons (UMons), Mons, Belgium
REMACLE, Sarah ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'ORL, d'audiophonologie et de chir. cervico-faciale
Finck, Camille ; Université de Liège - ULiège > Département des sciences cliniques > Phoniatrie ; Research Committee of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS
Saussez, Sven; Research Committee of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS ; Laboratory of Anatomy and Cell Biology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium ; Department of Otorhinolaryngology and Head and Neck Surgery, CHU Saint-Pierre, Brussels, Belgium
Language :
English
Title :
Validity and Reliability of the Reflux Sign Assessment.
The RSA is a complete clinical instrument evaluating both laryngeal and extralaryngeal findings associated with LPR. The RSA demonstrated high intra- and interrater reliabilities and responsiveness to change. laryngopharyngeal reflux laryngitis tool outcome finding sign Vesale Foundation (CHU Saint-Pierre, ULB, Brussels, Belgium) IRIS-Recherche (Fondation Roi Baudouin) edited-state corrected-proof Dr. Petros D. Karkos, Dr. Lise Crevier-Buchmann, Dr. Antonio Schindler, Dr. Abdul Latif Hamdan, and all members of the Expert committee where the content of the Reflux Symptom Score had been developed. American Journal Expert for the proofreading. Vesale Foundation (CHU Saint-Pierre, ULB, Brussels, Belgium) & IRIS-Recherche (Fondation Roi Baudouin) for the grants. Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Acknowledgment to IRIS-Recherche (Fondation Roi Baudouin) and Vesale Grant (CHU Saint-Pierre). ORCID iDs Jérôme R. Lechien https://orcid.org/0000-0002-0845-0845 Kathy Huet https://orcid.org/0000-0002-7160-7489 Supplemental Material Supplemental material for this article is available online.Dr. Petros D. Karkos, Dr. Lise Crevier-Buchmann, Dr. Antonio Schindler, Dr. Abdul Latif Hamdan, and all members of the Expert committee where the content of the Reflux Symptom Score had been developed. American Journal Expert for the proofreading. Vesale Foundation (CHU Saint-Pierre, ULB, Brussels, Belgium) & IRIS-Recherche (Fondation Roi Baudouin) for the grants. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Acknowledgment to IRIS-Recherche (Fondation Roi Baudouin) and Vesale Grant (CHU Saint-Pierre).
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