Article (Scientific journals)
Cytaphérèses pédiatriques (atelier SFGM-TC).
Chabannon, Christian; Benakli, Malek; Alexandrova, Kamelia et al.
2024In Bulletin du Cancer
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Keywords :
Apheresis; Atelier d’harmonisation; Cytaphérèse; Greffe de cellules souches hématopoïétiques; Guidelines; Hematopoietic cell transplantation; Pediatrics; Practice harmonization workshop; Pédiatrie; Recommandations; SFGM-TC; Cancer Research; Radiology, Nuclear Medicine and imaging; Oncology; Hematology; General Medicine
Abstract :
[en] Practice of pediatric aphereses - in particular when caring for low-weight children - differs from the practice of adult aphereses, since pediatric aphereses represent low numbers of procedures, which has practical implications in terms of practical training and retraining for involved healthcare personnel, as needed for habilitation and validation of ongoing competencies. A specific training is mandatory in order to ensure both the child and the staff safety during and after collection, as well as ensure high quality of the collected cell product and that its meets predefined specifications that depend on its intended use. Low and very low-weight children deserve a particular attention for a number of procedural and clinical aspects: the nature and quality of venous accesses to ensure proper operation of the cell separator, management of hemodynamic fluctuations in relation with the relative importance of the extracorporeal blood volume as compared to the total blood volume of the child, risks and clinical manifestations of citrate toxicity, minimization of stress during the procedure that may include but is not limited to pharmacological sedation. The full spectrum of competencies needed to deal with these aspects is rarely present within a single team of healthcare professionals; it most often requires the tight combination of expertise drawing from the collection facility, the pediatric department and possibly the pediatric intensive care unit ward, whether from the same or from different institutions. Interactions must be formalized in a document that accurately describes which category of actors is responsible for each category of acts (prescriptions, decisions), depending on their initial qualifications, specific competencies, and affiliations.
Disciplines :
Hematology
Author, co-author :
Chabannon, Christian;  Inserm CBT-1409 module biothérapies du centre d'investigations cliniques en biothérapies de Marseille, centre de thérapie cellulaire, institut Paoli-Calmettes, Aix-Marseille université, Marseille, France. Electronic address: chabannonc@ipc.unicancer.fr
Benakli, Malek;  Centre Pierre et Marie Curie, Algers, Algérie
Alexandrova, Kamelia;  Institut Gustave-Roussy, Villejuif, France
Coze, Carole;  Département d'hématologie et d'oncologie pédiatriques, hôpitaux universitaires de Marseille, Assistance publique-Hôpitaux de Marseille, Marseille, France
Dalle, Jean-Hughes;  Hôpital Robert-Debré, AP-HP, Paris, France
Giraud, Christine;  Centre hospitalier universitaire (CHU) de Poitiers, Poitiers, France
Huynh, Phuong;  Institut Jules Bordet, Bruxelles, Belgique
Kanouni, Tarik;  Unité d'aphérèse thérapeutique et d'hémovigilance, centre hospitalier universitaire (CHU) de Montpellier, 34295 Montpellier, France, Société française d'hémaphérèse (SFH), Paris, France
Kanold, Justyna;  Centre hospitalier universitaire (CHU) de Clermont-Ferrand, Clermont-Ferrand, France
Lesieur, Isabelle;  Établissement français du sang (EFS) Hauts-de-France - Normandie, Rouen, France
Levavasseur, Aurélie;  Établissement français du sang (EFS) Hauts-de-France - Normandie, Rouen, France, Centre Henri-Becquerel, Rouen, France
Yakoub-Agha, Ibrahim;  Inserm U995, LIRIC, université de Lille, CHU de Lille, 59000 Lille, France
Baudoux, Etienne  ;  Centre Hospitalier Universitaire de Liège - CHU > > Thérapie cellulaire
More authors (3 more) Less
Language :
French
Title :
Cytaphérèses pédiatriques (atelier SFGM-TC).
Alternative titles :
[en] Pediatric aphereses (workshop SFGM-TC).
Publication date :
12 March 2024
Journal title :
Bulletin du Cancer
ISSN :
0007-4551
eISSN :
1769-6917
Publisher :
Elsevier BV, France
Peer reviewed :
Peer Reviewed verified by ORBi
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