Rabies virus variants from bats closely related to variants found in marmosets (Callithrix jacchus), a neglected source of human rabies infection in Brazil.
de Sousa, Larissa L F; de Souza, Tatiane L; Tibo, Luiz H Set al.
2023 • In Journal of Medical Virology, 95 (8), p. 29046
[en] Rabies is a fatal viral zoonosis caused by rabies virus (RABV). RABV infects the central nervous system and triggers acute encephalomyelitis in both humans and animals. Endemic in the Brazilian Northeast region, RABV emergence in distinct wildlife species has been identified as a source of human rabies infection and as such, constitutes a public health concern. Here, we performed post-mortem RABV analyses of 144 encephalic tissues from bats sampled from January to July 2022, belonging to 15 different species. We identified phylogenetically distinct RABV from Phyllostomidae and Molossidae bats circulating in Northeastern Brazil. Phylogenetic clustering revealed the close evolutionary relationship between RABV viruses circulating in bats and variants hosted in white-tufted marmosets, commonly captured to be kept as pets and linked to human rabies cases and deaths in Brazil. Our findings underline the urgent need to implement a phylogenetic-scale epidemiological surveillance platform to track multiple RABV variants which may pose a threat to both humans and animals.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
de Sousa, Larissa L F; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP), São Paulo, São Paulo, Brazil ; Rabies Diagnosis Laboratory, Central Laboratory of Public Health-LACEN, Fortaleza, Ceará, Brazil
de Souza, Tatiane L; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP), São Paulo, São Paulo, Brazil
Tibo, Luiz H S; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP), São Paulo, São Paulo, Brazil
Moura, Francisco B P; Secretary of Health of the State of Ceará-SESA, Fortaleza, Ceará, Brazil
Junior, Francisco A S; Rabies Diagnosis Laboratory, Central Laboratory of Public Health-LACEN, Fortaleza, Ceará, Brazil
de Oliveira-Filho, Edmilson F ; Institute of Virology, Charité-Universitätsmedizin Berlin, Berlin, Germany
Ludwig-Begall, Louisa ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Santé publique vétérinaire
Cabral-Miranda, Gustavo; Institute of Biomedical Sciences, University of São Paulo (ICB/USP), São Paulo, São Paulo, Brazil
Andreata-Santos, Robert ; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP), São Paulo, São Paulo, Brazil
Janini, Luiz M R; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP), São Paulo, São Paulo, Brazil
Poon, Leo L M ; School of Public Health, The University of Hong Kong, Hong Kong, China
Durães-Carvalho, Ricardo ; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP), São Paulo, São Paulo, Brazil ; Department of Morphology and Genetics, UNIFESP, São Paulo, São Paulo, Brazil
Language :
English
Title :
Rabies virus variants from bats closely related to variants found in marmosets (Callithrix jacchus), a neglected source of human rabies infection in Brazil.
Publication date :
2023
Journal title :
Journal of Medical Virology
ISSN :
0146-6615
eISSN :
1096-9071
Publisher :
John Wiley & Sons, Hoboken, United States - New York
This research was funded by the São Paulo Research Foundation (FAPESP), Brazil, grants 2019/01255‐9 and 2021/03684‐4 (Young Investigator Program, R. D.‐C.), and grants 2022/09684‐9 (T. L. de Souza) and 2022/08748‐3 (L. H. S. Tibo). R. A.‐S. (grant 2021/05661‐1), L. M. R. J. (2020/08943‐5) and G. C.‐M. (grants 2019/14526‐0 and 2020/05146‐7) are supported by FAPESP. The authors gratefully acknowledge Prof. José Valter Joaquim Silva Jr. and Prof. Eduardo Furtado Flores from the Federal University of Santa Maria (UFSM) for providing the PCR‐positive control, and also thank the National Laboratory for Scientific Computing (LNCC/MCTI, Brazil) by the HPC resources of the Santos Dumont supercomputer (ID #45691, project “virusevolution”).This research was funded by the São Paulo Research Foundation (FAPESP), Brazil, grants 2019/01255-9 and 2021/03684-4 (Young Investigator Program, R. D.-C.), and grants 2022/09684-9 (T. L. de Souza) and 2022/08748-3 (L. H. S. Tibo). R. A.-S. (grant 2021/05661-1), L. M. R. J. (2020/08943-5) and G. C.-M. (grants 2019/14526-0 and 2020/05146-7) are supported by FAPESP. The authors gratefully acknowledge Prof. José Valter Joaquim Silva Jr. and Prof. Eduardo Furtado Flores from the Federal University of Santa Maria (UFSM) for providing the PCR-positive control, and also thank the National Laboratory for Scientific Computing (LNCC/MCTI, Brazil) by the HPC resources of the Santos Dumont supercomputer (ID #45691, project “virusevolution”).
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