[en] Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles. Conversely, other forms of selective autophagy (e.g. reticulophagy and lysophagy) enhance the cellular defense against ferroptotic damage. Dysregulated autophagy-dependent ferroptosis has implications for a diverse range of pathological conditions. This review aims to present an updated definition of autophagy-dependent ferroptosis, discuss influential substrates and receptors, outline experimental methods, and propose guidelines for interpreting the results.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Chen, Xin ; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China
Tsvetkov, Andrey S; Department of Neurology, The University of Texas McGovern Medical School at Houston, Houston, TX, USA
Shen, Han-Ming; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Macau, China
Isidoro, Ciro; Department of Health Sciences, University of Piemonte Orientale, Novara, Italy
Ktistakis, Nicholas T; Babraham Institute, Cambridge, UK
Linkermann, Andreas; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany ; Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
Koopman, Werner J H; Department of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud University, Nijmegen, The Netherlands ; Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands
Simon, Hans-Uwe ; Institute of Pharmacology, University of Bern, Bern, Switzerland ; Institute of Biochemistry, Brandenburg Medical School, Neuruppin, Germany
Galluzzi, Lorenzo; Peninsula Medical School, University of Plymouth, Plymouth, UK ; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA ; Sandra and Edward Meyer Cancer Center, New York, NY, USA
Luo, Shouqing; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA
Xu, Daqian; Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China
Gu, Wei; Institute for Cancer Genetics, and Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA
Peulen, Olivier ; Université de Liège - ULiège > GIGA > GIGA Cancer - Metastases Research Laboratory
Cai, Qian; Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
Rubinsztein, David C ; Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK ; UK Dementia Research Institute, University of Cambridge, Cambridge, UK
Chi, Jen-Tsan; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA
Zhang, Donna D; Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, University of Arizona, Tucson, AZ, USA
Li, Changfeng; Department of Endoscopy Center, China-Japan Union Hospital of Jilin University, Changchun, China
Toyokuni, Shinya; Department of Pathology and Biological Response, Nagoya University Graduate School of Medicine, Nagoya, Japan ; Center for Low-temperature Plasma Sciences, Nagoya University, Nagoya, Japan
Liu, Jinbao; Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China
Roh, Jong-Lyel; Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea
Dai, Enyong; The Second Department of Hematology and Oncology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China
Juhasz, Gabor; Biological Research Center, Institute of Genetics, Szeged, Hungary ; Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary
Liu, Wei; Department of Orthopedics, Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai, China
Zhang, Jianhua; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA
Yang, Minghua; Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China ; Hunan Clinical Research Center of Pediatric Cancer, Changsha, China
Liu, Jiao; DAMP Laboratory, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Zhu, Ling-Qiang; Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Zou, Weiping; Departments of Surgery and Pathology, University of Michigan Medical School, Ann Arbor, USA
Piacentini, Mauro; Department of Biology, University of Rome "Tor Vergata", Rome, Italy ; National Institute for Infectious Diseases IRCCS "Lazzaro Spallanzani", Rome, Italy
Ding, Wen-Xing; Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS, USA
Yue, Zhenyu; Department of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Xie, Yangchun; Department of Oncology, Central South University, Changsha, Hunan, China
Petersen, Morten; Functional genomics, Department of Biology, Copenhagen University, Denmark
Gewirtz, David A ; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA, USA
Mandell, Michael A; Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, USA
Chu, Charleen T; Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Sinha, Debasish; Department of Ophthalmology, University of Pittsburgh,Wilmer Eye Institute, The Johns Hopkins University School of Medicine, , Pittsburgh, Baltimore, MD, PA, USA
Eftekharpour, Eftekhar; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada
Zhivotovsky, Boris; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden ; Medicine, Lomonosov Moscow State University, Moscow, Russia ; Engelhardt Institute of Molecular Biology, Moscow, Russia
Besteiro, Sébastien; LPHI, University Montpellier, CNRS, Montpellier, France
Gabrilovich, Dmitry I; AstraZeneca, Early Oncology R&D, Gaithersburg, MD, USA
Kim, Do-Hyung; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA
Kagan, Valerian E; Department of Environmental Health, University of Pittsburgh, Pittsburgh, PA, USA
Bayir, Hülya; Department of Pediatrics, Columbia University, New York, USA
Chen, Guang-Chao; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
Ayton, Scott; Florey Institute, University of Melbourne, Parkville, Australia
Lünemann, Jan D; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany
Komatsu, Masaaki; Department of Physiology, Juntendo University School of Medicine, Bunkyo-ku Tokyo, Japan
Krautwald, Stefan; Department of Nephrology and Hypertension, University Hospital Schleswig-Holstein, Kiel, Germany
Loos, Ben; Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa
Baehrecke, Eric H; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA
Wang, Jiayi; Department of Clinical Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China ; Shanghai Institute of Thoracic Oncology Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China ; College of Medical Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Lane, Jon D; School of Biochemistry, University of Bristol, Bristol, UK
Sadoshima, Junichi; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, USA
Yang, Wan Seok; Department of Biological Sciences, St. John's University, New York City, NY, USA
Gao, Minghui; The HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
Münz, Christian; Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland
Thumm, Michael; Department of Cellular Biochemistry, University Medical Center Goettingen, Goettingen, Germany
Kampmann, Martin; Department of Biochemistry & Biophysics, University of California, San Francisco, San Francisco, USA ; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, USA
Yu, Di; Medicine, Frazer Institute, University of Queensland, Brisbane, Australia ; Medicine, Ian Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, University of Queensland, Brisbane, Australia
Lipinski, Marta M ; Department of Anesthesiology & Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA
Jones, Jace W; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA
Jiang, Xuejun; Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Zeh, Herbert J; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA
Kang, Rui; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA
Klionsky, Daniel J ; Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA
Kroemer, Guido ; Centre de Recherche des Cordeliers, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris, France ; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer, Villejuif, France ; Department of Biology, Institut du Cancer Paris CARPEM, Hôpital Européen Georges Pompidou, AP-HP, Paris, France
Tang, Daolin; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA
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