[en] [en] OBJECTIVES: The objective of this study was to evaluate the presence of traces of thiamazole in the urine of owners of hyperthyroid cats treated with antithyroid drugs.
METHODS: Urine was collected from 24 owners of hyperthyroid cats, five human patients treated with thiamazole and five healthy humans without any contact with antithyroid drugs. All owners of hyperthyroid cats were asked to fill out a questionnaire. Urine of hyperthyroid cats was collected by spontaneous micturition. All urine samples were stored at -20°C until analysis by ultra-high-performance liquid chromatography coupled to high-resolution quadrupole Orbitrap mass spectrometry.
RESULTS: These owners were assessed to have a lot of contact with their cat. Adherence to antithyroid medication handling guidelines was rather poor. High concentrations of thiamazole were detected in all feline samples (median concentration 2818 ng/ml; range 104-15,127) and in the urine of all human patients treated with thiamazole (median concentration 4153 ng/ml; range 1826-5009). No thiamazole was detected in the urine of owners of hyperthyroid cats (limit of detection 3.88 ng/ml; limit of quantification 11.75 ng/ml).
CONCLUSIONS AND RELEVANCE: The results regarding the potential exposure of owners of hyperthyroid cats to antithyroid drugs are reassuring. Nevertheless, prudence is still warranted when administering antithyroid drugs. Whether these results can be extrapolated to the use of transdermal application requires further investigation.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Schils, Gaëlle ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Médecine vétérinaire comparée ; Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
De Paepe, Ellen; Laboratory of Chemical Analysis, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
Lapauw, Bruno; Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University Hospital, Ghent, Belgium
Vanden Broecke, Ellen; Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
Van Mulders, Laurens; Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
Vanhaecke, Lynn; Laboratory of Chemical Analysis, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
Lyssens, Aurélie ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Médecine vétérinaire comparée
Stammeleer, Lisa ; Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
Daminet, Sylvie ; Université de Liège - ULiège ; Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
Language :
English
Title :
Evaluation of potential thiamazole exposure of owners of orally treated hyperthyroid cats.
The authors would like to thank Dr Ingrid De Beleyr and the endocrinology service of Ghent University Hospital for their assistance with this study. The authors received no financial support for the research, authorship, and/or publication of this article.
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