Le médicament du moisMavacamten (Camzyos®) : premier inhibiteur réversible de l’ATP-ase de la myosine pour le traitement des cardiomyopathies hypertrophiques obstructives.
Lancellotti, Patrizio; de Marneffe, Nils; Scheen, André
2024 • In Revue Médicale de Liège, 79 (2), p. 120-128
[en] Mavacamten (Camzyos®) is a myosin modulator which reduces the interactions between myosin and actin. These are overly activated in hypertrophic cardiomyopathy (HCM), a source of exaggerated ventricular contractility, energy loss, and impairment of diastolic function (relaxation). The Food and Drug Administration (FDA) and the European Medication Agency (EMA) approved mavacamten for the treatment of symptomatic obstructive HCM (NYHA class II or III) in adult patients in 2022 and 2023, respectively. The medication is not yet reimbursed in Belgium. As seen in its clinical development studies, mavacamten reduces the intraventricular gradient, improves functional capacity and reduces symptoms. It also seems to be an innovative alternative to septal reduction. Mavacamten is usually very well tolerated knowing that, through its mechanism of action, it causes a dose-dependent and reversible reduction in left ventricular ejection fraction, which must therefore be closely monitored. The good tolerance and the effectiveness of mavacamten seem to be maintained over time. Consequently, the recent European Society of Cardiology Updated Guidelines on cardiomyopathy (ESC 09/2023) already recommend mavacamten in the pharmacological management of obstructive HCM.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Lancellotti, Patrizio ; Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
de Marneffe, Nils ; Université de Liège - ULiège > Département des sciences cliniques
Scheen, André ; Université de Liège - ULiège > Département des sciences cliniques
Language :
French
Title :
Le médicament du moisMavacamten (Camzyos®) : premier inhibiteur réversible de l’ATP-ase de la myosine pour le traitement des cardiomyopathies hypertrophiques obstructives.
Alternative titles :
[en] Mavacamten (Camzyos ®) : first myosin modulator for obstructive hypertrophic cardiomyopathy treatment.
Publication date :
February 2024
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Be