Bone regeneration; Bone scaffolds; Calcium phosphates; Ionic substitution; Octacalcium phosphate; Osteogenesis; Biological properties; Biomedical applications; Bone tissue regeneration; Ionic substitutions; Osteogenic; Property; Electronic, Optical and Magnetic Materials; Ceramics and Composites; Process Chemistry and Technology; Surfaces, Coatings and Films; Materials Chemistry
Abstract :
[en] Numerous studies have found that octacalcium phosphate possesses promising biological properties applicable to bone tissue regeneration. To further improve the osteogenic and regenerative properties of octacalcium phosphate, substitutions with Sr2+, Zn2+, Mg2+, Fe3+, Na+, F− and CO32− ions have been investigated in recent years. Despite that, hydroxyapatite is still considered the most promising calcium phosphate for bioactive bone grafts due to its biocompatibility, physicochemical similarity to biological apatite, osteoconductivity and strong bonding with the surrounding tissue. However, better biological properties of octacalcium phosphate in vivo as well as a larger volume of regenerated bone tissue, compared to hydroxyapatite, were confirmed by many studies. This review summarizes recent and relevant studies on cationic and anionic substitutions in the crystal lattice of octacalcium phosphate and its in vitro biological performance. It also discusses future challenges and prospects for the use of substituted octacalacium phosphate.
Disciplines :
Chemistry
Author, co-author :
Ressler, Antonia; Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia
Ivanišević, Irena; Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia
Žužić, Andreja; Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia
Somers, Nicolas ; Université de Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM) ; Univ. Polytechnique Hauts-de-France, EA 2443 – LMCPA – Laboratoire des Matériaux Céramiques et Procédés Associés, Valenciennes, France ; Belgian Ceramic Research Centre – Member of EMRA, Mons, Belgium
Language :
English
Title :
The ionic substituted octacalcium phosphate for biomedical applications: A new pathway to follow?
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