Bioceramics; Direct Ink Writing; Doping; Osmotic drying; Sintering; β-TCP; Bone regeneration; Bone repair; Co-doped; Direct ink writing; Macroporous; Repair applications; Tri-calcium phosphates; Tricalcium phosphate bioceramics; Ceramics and Composites; Materials Chemistry
Abstract :
[en] β-tricalcium phosphate (β-TCP, β-Ca3(PO4)2) is one of the most attractive biomaterials for bone regeneration and β-TCP macroporous scaffolds are very promising for both cell proliferation and mechanical support. The Additive Manufacturing (AM) process called Direct Ink Writing (DIW), based on the extrusion of a concentrated ceramic slurry, is particularly adapted to resolve the main drawbacks associated with conventional shaping of ceramic scaffolds. In this work, co-doped β-TCP powders were synthetized and used to print macroporous scaffolds by DIW. Doped β-TCP powders have been proved to exhibit higher thermal stability, densification and mechanical properties compared to undoped β-TCP. Two co-doped compositions were produced via the aqueous precipitation technique combining magnesium, strontium, silver and copper cations: Mg-Sr (2.0–2.0 mol%) and Mg-Sr-Ag-Cu (2.0–2.0–0.1–0.1 mol%). DIW slurries were optimized with undoped and co-doped β-TCP with the use of a dispersant and a carboxymethylcellulose and polyethyleneimine mixture to obtain aqueous slurries filled with 42 vol% of powder. Complete rheological characterizations were realized to assess the suitability of the β-TCP slurries for the DIW process (shear-thinning and thixotropic behaviour). The whole processing chain including printing, osmotic drying (PEG 10000) and sintering (1100 °C, 3 h) was optimized to successfully print co-doped β-TCP macroporous scaffolds. Characterizations after sintering showed a reduction of macropores and microcracks using co-doped β-TCP powders as well as improved compressive strengths and densities compared to undoped β-TCP. A significant enhancement of compressive strength values was obtained compared to literature data.
Disciplines :
Chemistry
Author, co-author :
Somers, Nicolas ; Université de Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM) ; CERAMATHS-Department Materials and Processing, Université Polytechnique Hauts-de-France, Valenciennes, France ; INSA Hauts-de-France, Campus Mont Houy, Valenciennes Cedex 9, France
Jean, Florian ; CERAMATHS-Department Materials and Processing, Université Polytechnique Hauts-de-France, Valenciennes, France ; INSA Hauts-de-France, Campus Mont Houy, Valenciennes Cedex 9, France
Lasgorceix, Marie; CERAMATHS-Department Materials and Processing, Université Polytechnique Hauts-de-France, Valenciennes, France ; INSA Hauts-de-France, Campus Mont Houy, Valenciennes Cedex 9, France
Preux, Nicolas; Belgian Ceramic Research Centre, Mons, Belgium
Delmotte, Cathy; Belgian Ceramic Research Centre, Mons, Belgium
Boilet, Laurent ; Belgian Ceramic Research Centre, Mons, Belgium
Petit, Fabrice; Belgian Ceramic Research Centre, Mons, Belgium
Leriche, Anne; CERAMATHS-Department Materials and Processing, Université Polytechnique Hauts-de-France, Valenciennes, France ; INSA Hauts-de-France, Campus Mont Houy, Valenciennes Cedex 9, France
Language :
English
Title :
Fabrication of doped β-tricalcium phosphate bioceramics by Direct Ink Writing for bone repair applications
H2020 - 764935 - DOC-3D-PRINTING - Development Of Ceramics 3D-Printing, Additive Manufacturing
Funders :
EU - European Union
Funding text :
The authors are grateful to the “DOC 3D Printing” project for financial support. This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 764935 .
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