Prevalence of cerebral palsy and factors associated with cerebral palsy subtype:  A population-based study in Belgium.

Dhondt, Evy; Dan, Bernard; Plasschaert, Frank; Degelaen, Marc; Dielman, Charlotte; Dispa, Delphine; Ebetiuc, Natalia Iulianna; Hasaerts, Danielle; Kenis, Sandra; Lombardo, Costanza; Pelc, Karine; Wermenbol, Vanessa; Ortibus, Els; Belgian Cerebral Palsy, Register

doi:10.1016/j.ejpn.2023.06.003

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Article (Scientific journals)

Prevalence of cerebral palsy and factors associated with cerebral palsy subtype: A population-based study in Belgium.

Dhondt, Evy; Dan, Bernard; Plasschaert, Frank et al.

2023 • In European Journal of Paediatric Neurology, 46, p. 8-23

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https://hdl.handle.net/2268/313426

DOI
10.1016/j.ejpn.2023.06.003

PubMed
37364404

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Keywords :

Ataxia; Cerebral palsy; Dyskinesia; Magnetic resonance imaging; Prevalence; Spasticity

Abstract :

[en] AIM: To report on the prevalence, neuroimaging patterns, and function of children with cerebral palsy (CP) in Belgium for birth years 2007-2012, and identify distinctive risk indicators and differences in outcome between CP subtypes. METHODS: Antenatal and perinatal/neonatal factors, motor and speech function, associated impairments, and neuroimaging patterns were extracted from the Belgian Cerebral Palsy Register. Prevalence was estimated per 1000 (overall, ante/perinatal, spastic, dyskinetic CP) or 10,000 (post-neonatal, ataxic CP) live births. Multinomial logistic regression analyses were performed to ascertain the effects of antenatal/perinatal/neonatal factors and neuroimaging patterns on the likelihood of dyskinetic or ataxic CP relative to spastic CP, and test the likelihood of the occurrence of impaired motor and speech function and associated impairments in dyskinetic or ataxic CP relative to spastic CP. RESULTS: In total, 1127 children with CP were identified in Belgium. The birth prevalence of overall CP was 1.48 per 1000 live births. The likelihood of dyskinetic CP increases if the child was born to a mother aged ≥35 years, mechanically ventilated, and had predominant grey matter injury, while an increased likelihood of ataxic CP is associated with ≥2 previous deliveries. Children with dyskinetic and ataxic CP are more likely to function with impairments in motor, speech, and intellectual abilities. CONCLUSION: Distinctive risk indicators and differences in outcome between CP subtypes were identified. These factors can be incorporated into clinical practice to facilitate early, accurate, and reliable classification of CP subtype, and may lead to individually tailored neonatal care and other (early) intervention options.

Disciplines :

Pediatrics
Neurology

Author, co-author :

Dhondt, Evy; Department of Development and Regeneration, KU Leuven, Leuven, Belgium. Electronic address: evy.dhondt@kuleuven.be.

Dan, Bernard; Inter-University Reference Centre for Cerebral Palsy (CIRICU), Inkendaal Rehabilitation Hospital, Vlezenbeek, Belgium, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium.

Plasschaert, Frank; Cerebral Palsy Reference Centre, University Hospital Ghent, Ghent, Belgium, Human Structure and Repair, Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Degelaen, Marc; Inter-University Reference Centre for Cerebral Palsy (CIRICU), Inkendaal Rehabilitation Hospital, Vlezenbeek, Belgium, Department of Rehabilitation Research, Vrije Universiteit Brussel, Brussels, Belgium.

Dielman, Charlotte; Cerebral Palsy Reference Centre Antwerp (CePRA), Ziekenhuis Netwerk Antwerpen Queen Paola Children's Hospital, Wilrijk, Belgium.

Dispa, Delphine; Reference Centre for Cerebral Palsy (IMOC), Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Ebetiuc, Natalia Iulianna ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie

Hasaerts, Danielle; Inter-University Reference Centre for Cerebral Palsy (CIRICU), University Hospital Brussels, Brussels, Belgium.

Kenis, Sandra; Cerebral Palsy Reference Centre Antwerp (CePRA), Antwerp University Hospital, Belgium.

Lombardo, Costanza; Inter-University Reference Centre for Cerebral Palsy (CIRICU), Queen Fabiola Children's University Hospital (QFCUH), Brussels, Belgium.

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Language :

English

Title :

Prevalence of cerebral palsy and factors associated with cerebral palsy subtype: A population-based study in Belgium.

Publication date :

September 2023

Journal title :

European Journal of Paediatric Neurology

eISSN :

1532-2130

Volume :

Pages :

8-23

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