Preparation of Dinitrogen Trioxide for Organic Synthesis: A Phase Equilibrium Approach

[en] Dinitrogen trioxide (N2O3 ) is a potent nitrosating agent featured with high reactivity and appealing atom economy. Because of its instability and the entanglement of chemical and phase equilibria, N2O3 has rarely been utilized in organic synthesis as a stock reagent with well-defined composition. In this review,the preparations of pure N2O3 and its concentrated solution (>0.1 M) are discussed from the aspect of phase equilibrium. Understanding the physical and chemical characteristics of N2 O3 , along with how reaction parameters (temperature, pressure, molar ratio) interact, plays a crucial role in managing the concentration of N2O3 in the liquid phase. This control holds practical significance in achieving quantitative reactions.

Research center :

MolSys - Molecular Systems - ULiège [BE]
Center for Integrated Technology and Organic Synthesis
WEL Research Institute

Disciplines :

Chemistry

Author, co-author :

Chen, Yuesu ; Université de Liège - ULiège > Molecular Systems (MolSys)

Monbaliu, Jean-Christophe ; Université de Liège - ULiège > Molecular Systems (MolSys) ; WEL Research Institute, Avenue Pasteur 6, 1300, Wavre, Belgium

Language :

English

Title :

Preparation of Dinitrogen Trioxide for Organic Synthesis: A Phase Equilibrium Approach

Publication date :

17 January 2024

Journal title :

Chemistry

ISSN :

0947-6539

eISSN :

1521-3765

Publisher :

Wiley, Germany

Pages :

e202303516

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 13 February 2024

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8 (6 by ULiège)

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9 (4 by ULiège)

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