[en] The configuration and orientation of tumor-promoting and biologically inactive phorbol esters at a simulated lipid-water interface were established by conformational analysis. Selected conformers were then examined by a new computation method to form clusters of molecules representative of a monolayer arrangement. the results of this theoretical analysis were in good aggreement with experimental data obtained in pure monolayers of phorbol esters spread at an air-water interface, and lay help to elucidate the determinants of their biological potency.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Brasseur, Robert ; ULB - Université Libre de Bruxelles [BE] > Laboratory of experimental medicine and physical chemistry of macromolecules
Deleers, M.; ULB - Université Libre de Bruxelles [BE] > Laboratory of experimental medicine and physical chemistry of macromolecules
Ruysschaert, J.-M.; ULB - Université Libre de Bruxelles [BE] > Laboratory of experimental medicine and physical chemistry of macromolecules
Malaisse, W.J.; ULB - Université Libre de Bruxelles [BE] > Laboratory of experimental medicine and physical chemistry of macromolecules
Language :
English
Title :
Conformational analysis of phorbol esters monolayers
Publication date :
1982
Journal title :
Biochemistry International
ISSN :
0158-5231
Publisher :
Academic Press, New York, United States - New York
