[en] We demonstrate here that drugs which inactivate cytochrome c oxidase are able to segregate cardiolipin essential for the enzyme activity, in a separate phase inaccessible for the enzyme. A molecular explanation of the drug-induced aggregation process is proposed.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Huart, P; Laboratoire de Chimie Physique des Macromolécules aux Interfaces, Université Libre de Bruxelles, 1050 Bruxelles, Belgium
Brasseur, Robert ; Laboratoire de Chimie Physique des Macromolécules aux Interfaces, Université Libre de Bruxelles, 1050 Bruxelles, Belgium
Goormaghtigh, E; Laboratoire de Chimie Physique des Macromolécules aux Interfaces, Université Libre de Bruxelles, 1050 Bruxelles, Belgium
Ruysschaert, J M; Laboratoire de Chimie Physique des Macromolécules aux Interfaces, Université Libre de Bruxelles, 1050 Bruxelles, Belgium
Language :
English
Title :
Antimitotics induce cardiolipin cluster formation. Possible role in mitochondrial enzyme inactivation.
One of us (P.H.) thanksI RSIA for financial support.A driamycinw as generouslsyu ppliedb y the National Cancer Institute. We thank the 'BanqueN ationaled e Belgiquef'o r its help. E.G. is ResearchA ssistanto f the National Fund for ScientificR esearch(B elgium).
