Antimitotics induce cardiolipin cluster formation. Possible role in mitochondrial enzyme inactivation.

Cardiolipins; Liposomes; Macromolecular Substances; Pulmonary Surfactants; Doxorubicin; Electron Transport Complex IV; Ethidium; Acridine Orange; Acridine Orange/pharmacology; Animals; Calorimetry, Differential Scanning; Cardiolipins/metabolism; Cattle; Doxorubicin/pharmacology; Electron Transport Complex IV/antagonists & inhibitors; Ethidium/pharmacology; Mitochondria, Heart/enzymology; Antimitotic; Cardiolipin cluster; Enzyme inactivation; Biophysics; Biochemistry; Molecular Biology

Abstract :

[en] We demonstrate here that drugs which inactivate cytochrome c oxidase are able to segregate cardiolipin essential for the enzyme activity, in a separate phase inaccessible for the enzyme. A molecular explanation of the drug-induced aggregation process is proposed.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Huart, P; Laboratoire de Chimie Physique des Macromolécules aux Interfaces, Université Libre de Bruxelles, 1050 Bruxelles, Belgium

Brasseur, Robert ; Laboratoire de Chimie Physique des Macromolécules aux Interfaces, Université Libre de Bruxelles, 1050 Bruxelles, Belgium

Goormaghtigh, E; Laboratoire de Chimie Physique des Macromolécules aux Interfaces, Université Libre de Bruxelles, 1050 Bruxelles, Belgium

Ruysschaert, J M; Laboratoire de Chimie Physique des Macromolécules aux Interfaces, Université Libre de Bruxelles, 1050 Bruxelles, Belgium

Language :

English

Title :

Antimitotics induce cardiolipin cluster formation. Possible role in mitochondrial enzyme inactivation.

Publication date :

15 June 1984

Journal title :

Biochimica et Biophysica Acta

ISSN :

0006-3002

eISSN :

1878-2434

Publisher :

Elsevier BV, Netherlands

Volume :

799

Issue :

Pages :

199 - 202

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:0304416584902964?httpAccept=text/xml

Funding text :

One of us (P.H.) thanksI RSIA for financial support.A driamycinw as generouslsyu ppliedb y the National Cancer Institute. We thank the 'BanqueN ationaled e Belgiquef'o r its help. E.G. is ResearchA ssistanto f the National Fund for ScientificR esearch(B elgium).

Available on ORBi :

since 08 February 2024

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