Iodine Radioisotopes; Animals; Dogs; Iodine Radioisotopes/therapeutic use; Quality of Life; Retrospective Studies; Dog Diseases/etiology; Dog Diseases/radiotherapy; Hyperthyroidism/radiotherapy; Hyperthyroidism/veterinary; Thyroid Dysgenesis/veterinary; Thyroid Neoplasms/radiotherapy; Thyroid Neoplasms/veterinary; Dog Diseases; Hyperthyroidism; Thyroid Dysgenesis; Thyroid Neoplasms; Small Animals
Abstract :
[en] [en] OBJECTIVES: This study aimed to describe the clinical and diagnostic characteristics, as well as outcomes of radioiodine treatment in dogs with hyperthyroidism caused by a non-resectable ectopic thyroid tumour.
MATERIALS AND METHODS: This retrospective study reviewed the medical records between 2008 and 2018 of dogs diagnosed with hyperthyroidism secondary to a non-resectable ectopic thyroid tumour and treated with radioiodine.
RESULTS: Five dogs were included in the study. Three dogs had sublingual ectopic tumours, of which one also had a unilateral cervical thyroid tumour. The remaining two dogs were diagnosed with an ectopic thyroid tumour at the level of the caudal pharynx and the heart base, respectively. All cases were treated with radioiodine. The size of the ectopic masses decreased after radioiodine treatment. Total thyroxine concentrations returned to reference ranges in all dogs. Further, clinical signs of hyperthyroidism disappeared after treatment in all patients. One dog developed myelosuppression secondary to radioiodine treatment. The dog with metastasis had a very short survival compared to the four dogs without metastasis (3 months compared to 7, 36, 50 and 24 months, respectively) and succumbed most likely to thyroid-related problems. In the remaining four dogs, their quality of life improved. They died due to diseases unrelated to the ectopic thyroid tumour.
CLINICAL SIGNIFICANCE: Radioiodine therapy should be considered as a treatment option in dogs diagnosed with hyperthyroidism due to a non-resectable ectopic thyroid tumour.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Lyssens, Aurélie ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Médecine vétérinaire comparée ; Department of Small Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, 9820, Belgium
van den Berg, M F; Department of Small Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, 9820, Belgium
Peremans, K; Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, 9820, Belgium
Vandermeulen, E; Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, 9820, Belgium
Daminet, S; Department of Small Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, 9820, Belgium
Language :
English
Title :
131 treatment in dogs with hyperthyroidism caused by a non-resectable ectopic thyroid tumour: 5 cases (2008-2019).
Adams, W., Walker, M., Daniel, G., et al. (1995) Treatment of differentiated thyroid carcinoma in 7 dogs utilizing 131I. Veterinary Radiology & Ultrasound 36, 417-424
Ahmed, A., Kamath, N., El Kossi, M., et al. (2010) The impact of stopping of the renin-angiotensin system in patients with adapted chronic kidney disease. Nephrology Dialysis Transplant 25, 3977-3982
Avram, A. (2012) Radioiodine scintigraphy with SPECT/CT: an important diagnostic tool for thyroid cancer staging and risk stratification. Journal of Nuclear Medicine 53, 754-764
Babazade, F., Mortazavi, H., Jalalian, H., et al. (2009) Thyroid tissue as a submandibular mass: a case report. Journal of Oral Science 51, 655-657
Barber, L. G. (2007) Thyroid tumors in dogs and cats. Veterinary Clinics of North America: Small Animal Practice 37, 755-773
Bezzola, P. (2002) Thyroid carcinoma and hyperthyroidism in a dog. Canadian Veterinary Journal 43, 125-126
Bracha, S., Caron, I., Holmberg, D. L., et al. (2009) Ectopic thyroid carcinoma causing right ventricular outflow tract obstruction in a dog. Journal of the American Animal Hospital Association 45, 138-141
Broome, M. R., Peterson, M. E. & Walker, J. R. (2014) Clinical features and treatment outcomes of 41 dogs with sublingual ectopic thyroid neoplasia. Journal of Veterinary Internal Medicine 28, 1560-1568
Campos, M., Ducatelle, R., Rutteman, G., et al. (2014) Clinical, pathologic and immunohistochemical prognostic factors in dogs with thyroid carcinoma. Journal of Veterinary Internal Medicine 28, 1805-1813
Daniel, G. & Neelis, D. (2014) Thyroid scintigraphy in veterinary medicine. Seminars in Nuclear Medicine 44, 24-34
DiBartola, S. P., Broome, M. R., Stein, B. S., et al. (1996) Effect of treatment of hyperthyroidism on renal function in cats. Journal of the American Veterinarian Association 208, 875-878
Gommeren, K., Van Hoek, I., Lefebvre, H., et al. (2009) Effect of thyroxine supplementation on glomerular filtration rate in hypothyroid dogs. Journal of Veterinary Internal Medicine 23, 844-849
Harari, J., Patterson, J. S. & Rosenthal, R. C. (1986) Clinical and pathologic features of thyroid tumors in 26 dogs. Journal of the American Veterinary Medical Association 188, 1160-1164
Haugen, B. & Lin, E. (2001) Isotope imaging for metastatic thyroid cancer. Endocrinology and Metabolism Clinics of North America 30, 469-492
Ibrahim, N. A. & Fadeyibi, I. O. (2011) Ectopic thyroid: etiology, pathology and management. Hormones 10, 261-269
Kameda, Y. (1972) Accessory thyroid glands of the dog around the intrapericardial aorta. Archivum Histologicum Japonicum 34, 375-391
Kang, M., Kim, D. & Park, H. (2012) Ectopic thyroid carcinoma infiltrating the right atrium of the heart in a dog. Canadian Veterinary Journal 53, 177-181
Lantz, G. C. & Salisbury, S. K. (1989) Surgical excision of ectopic thyroid carcinoma involving the base of the tongue in three dogs: three cases (1980-1987). Journal of the American Veterinary Medical Association 195, 606-608
Leblanc, A. & Peremans, K. (2014) PET and SPECT imaging in veterinary medicine. Seminars in Nuclear Medicine 44, 47-56
Liptak, J. M. (2007) Canine thyroid carcinoma. Clinical Techniques in Small Animal Practice 22, 75-81
Liptak, J. M., Kamstock, D. A., Dernell, W. S., et al. (2008) Cranial mediastinal carcinomas in nine dogs. Veterinary and Comparative Oncology 6, 19-30
Marks, S., Koblik, P., Hornof, W., et al. (1994) 99m-Tc pertechnetate imaging of thryoid tumors in dogs: 29 cases (1980-1992). Journal of the American Veterinary Medical Association 204, 756-760
Mazzaferri, E. (2001) Thyroid cancer. In: Principles and Practice of Endocrinology and Metabolism. 3rd edn. Ed K. Becker. Williams and Wilkins, Philadelphia, PA, USA. pp 382-396
Milovancev, M., Wilson, D., Monnet, E., et al. (2014) Partial resection of the hyoid apparatus during surgical treatment of ectopic thyroid carcinomas in dogs: 5 cases (2011-2013). Journal of the American Veterinary Medical Association 245, 1319-1324
Noussios, G., Anagnostis, P., Goulis, D. G., et al. (2011) Ectopic thyroid tissue: anatomical, clinical and surgical implications of a rare entity. European Journal of Endocrinology 165, 375-382
Owens, L. (1980) Endocrine glands. In: TMN Classification of Tumours in Domestic Animals. 1st edn. Ed L. Owens, Geneva, Switzerland. WHO, pp 51-53
Peterson, M. E., Kintzer, P. P., Hurley, J. R., et al. (1989) Radioactive iodine treatment of a functional thyroid carcinoma producing hyperthyroidism in a dog. Journal of Veterinary Internal Medicine 3, 20-25
Rijnberk, A. (1966) Hyperthyroidism in the dog and its treatment with radioactive iodide. Tijdschrift voor Diergeneeskunde 91, 789-794
Scott-Moncrieff, J. C. (2014) Canine thyroid tumors and hyperthyroidism. In: Canine and Feline Endocrinology. 4th edn. Eds E. C. Feldman, R. Nelson, C. Reusch, et al. Elsevier, St. Louis, MO, USA. pp 196-212
Taeymans, O., Peremans, K. & Saunders, J. (2007) Thyroid imaging in dogs: current status and future directions. Journal of Veterinary Internal Medicine 21, 673-684
Théon, A., Marks, S., Feldman, E., et al. (2000) Prognostic factors and patterns of treatment failure in dogs with unresectable differentiated thyroid carcinomas treated with megavoltage irradiation. Journal of the American Veterinary Medical Association 216, 1775-1779
Turrel, J. M., McEntee, M. C., Burke, B. P., et al. (2006) Sodium iodide I 131 treatment of dogs with nonresectable thyroid tumors: 39 cases (1990-2003). Journal of the American Veterinary Medical Association 229, 542-548
Van Hoek, I., Daminet, S., Vandermeulen, E., et al. (2008) Recombinant human thyrotropin administration enhances thyroid uptake of radioactive iodine in hyperthyroid cats. Journal of Veterinary Internal Medicine 22, 1340-1344
Van Hoek, I., Lefebvre, H., Peremans, K., et al. (2009) Short and long term follow up of glomerular and tubular renal markers of kidney function in hyperthyroid cats after treatment with radioiodine. Domestic Animal Endocrinology 36, 45-56
Ward, C. (2017) Canine hyperthyroidism. In: Textbook of Veterinary Internal Medicine. 8th edn. Eds S. J. Ettinger, E. C. Feldman and E. Côté. Elsevier, St. Louis, MO, USA. pp 1756-1761
Worth, A., Zuber, R. & Hocking, M. (2005) Radioiodide (131I) therapy for the treatment of canine thyroid carcinoma. Australian Veterinary Journal 83, 208-214
Yoon, J. S., Won, K. C., Cho, I. H., et al. (2007) Clinical characteristics of ectopic thyroid in Korea. Thyroid 17, 1117-1121
Ziessman, A., O'Malley, P., Thrall, H., et al. (2016) Endocrine system. In: Nuclear Medicine: The Requisites. 4th edn. Eds A. Ziessman, P. O'Malley and H. Thrall. Elsevier, St. Louis, MO, USA. pp 66-97
