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Article (Scientific journals)
Interstrand DNA crosslinks due to AP (apurinic/apyrimidinic) sites.
Goffin, Colette; Verly, Walter
1983 • In FEBS Letters, 161 (1), p. 140 - 144
Peer Reviewed verified by ORBi
Permalink
https://hdl.handle.net/2268/312466
DOI
10.1016/0014-5793(83)80747-9
PubMed
6884524
 

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FEBS Letters - September 05 1983 - Goffin - Interstrand DNA crosslinks due to AP apurinic apyrimidinic sites.pdf
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Keywords :
DNA, Viral; Polynucleotides; apyrimidinic acid; Tritium; Apurinic Acid; Chemical Phenomena; Chemistry; Nucleic Acid Denaturation; T-Phages; AP site; Interstrand DNA crosslink; Ionizing radiation; Biophysics; Structural Biology; Biochemistry; Molecular Biology; Genetics; Cell Biology
Abstract :
[en] Storage of a solution of DNA containing apurinic sites, even at 4 degrees C leads to the appearance of interstrand crosslinks. Possible biological consequences of these crosslinks, when they appear in cell DNA, are briefly discussed. Formation of interstrand crosslinks in DNA containing tritium-labelled thymine and kept in an aqueous solution might be due, at least partly, to the loss of bases by the autoirradiated DNA.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Goffin, Colette ;  Université de Liège - ULiège > Département des sciences de la vie > Centre d'Ingénierie des Protéines (CIP)
Verly, Walter ;  Relations académiques et scientifiques (Sciences)
Language :
English
Title :
Interstrand DNA crosslinks due to AP (apurinic/apyrimidinic) sites.
Alternative titles :
[fr] Liaisons transversales entre brins d'ADN dues à des sites AP (apuriniques/apyrimidiniques).
Publication date :
05 September 1983
Journal title :
FEBS Letters
ISSN :
0014-5793
eISSN :
1873-3468
Publisher :
Wiley, England
Volume :
161
Issue :
1
Pages :
140 - 144
Peer reviewed :
Peer Reviewed verified by ORBi
Additional URL :
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793%2883%2980747-9
Funding text :
This work was supportedb y grants from the Fonds CancCrologiqued e la CGER and the Fonds de la RechercheS cientifiqueM Cdicale.C.G. was the recipiento f an IRSIA fellowship.
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