[en] Storage of a solution of DNA containing apurinic sites, even at 4 degrees C leads to the appearance of interstrand crosslinks. Possible biological consequences of these crosslinks, when they appear in cell DNA, are briefly discussed. Formation of interstrand crosslinks in DNA containing tritium-labelled thymine and kept in an aqueous solution might be due, at least partly, to the loss of bases by the autoirradiated DNA.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Goffin, Colette ; Université de Liège - ULiège > Département des sciences de la vie > Centre d'Ingénierie des Protéines (CIP)
Verly, Walter ; Relations académiques et scientifiques (Sciences)
Language :
English
Title :
Interstrand DNA crosslinks due to AP (apurinic/apyrimidinic) sites.
Alternative titles :
[fr] Liaisons transversales entre brins d'ADN dues à des sites AP (apuriniques/apyrimidiniques).
This work was supportedb y grants from the Fonds CancCrologiqued e la CGER and the Fonds de la RechercheS cientifiqueM Cdicale.C.G. was the recipiento f an IRSIA fellowship.
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