[en] In this brief report, we present our experience with 3-weekly paclitaxel-carboplatin chemotherapy for patients with vulvar cancer. Two patients with locally advanced disease had an impressive response allowing standard vulvar cancer surgery. One patient with metastatic disease had local stable disease though it was progressive in the lymph nodes. The available literature is sparse and retrospective. Based on promising results, however, a prospective multicenter study is mandatory in order to obtain full data in a larger series of patients in order to learn the benefits of neoadjuvant paclitaxel-carboplatin and compare the results with chemoradiation.
Disciplines :
Oncology
Author, co-author :
Amant, Frédéric; Department of Gynecologic Oncology, Center for Gynecologic Oncology, the Netherlands Cancer Institute, Antoni van Leeuwenhoek, Amsterdam, the Netherlandsf.amant@nki.nl ; Department of Oncology, KU Leuven, Leuven, Belgiumf.amant@nki.nl ; Department of Obstetrics-Gynecology, University Hospitals Leuven, Leuven, Belgiumf.amant@nki.nl
Nooij, Linda; Department of Gynecologic Oncology, Center for Gynecologic Oncology, the Netherlands Cancer Institute, Antoni van Leeuwenhoek, Amsterdam, the Netherlands
Annibali, Daniela ; Department of Oncology, KU Leuven, Leuven, Belgium ; Department of Obstetrics-Gynecology, University Hospitals Leuven, Leuven, Belgium
van Rompuy, Anne-Sophie; Department of Pathology, University Hospitals Leuven, Leuven, Belgium
Han, Sileny; Department of Obstetrics-Gynecology, University Hospitals Leuven, Leuven, Belgium
van den Bulck, Heidi; Department of Medical Oncology, University Hospitals Leuven, Leuven, Belgium ; Department of Medical Oncology, Imelda Hospital, Bonheiden, Belgium
Goffin, Frédéric ; Centre Hospitalier Universitaire de Liège - CHU > > Service de gynécologie-obstétrique (CHR) ; Department of Obstetrics-Gynecology, Hospital of la Citadelle, Liège, Belgium
Language :
English
Title :
Brief Report on 3-Weekly Paclitaxel Carboplatin Efficacy in Locally Advanced or Metastatic Squamous Vulvar Cancer.
Gadducci A, Cionini L, Romanini A, Fanucchi A, Genazzani AR: Old and new perspectives in the management of high-risk, locally advanced or recurrent, and metastatic vulvar cancer. Crit Rev Oncol Hematol 2006; 60: 227-241.
Hacker NF, Eifel PJ, van der Velden J: Cancer of the vulva. Int J Gynaecol Obstet 2015; 131(suppl 2):S76-S83.
Gaarenstroom KN, Kenter GG, Trimbos JB, Agous I, Amant F, Peters AA, Vergote I: Postoperative complications after vulvectomy and inguinofemoral lymphadenectomy using separate groin incisions. Int J Gynecol Cancer 2003; 13: 522-527.
Gonzalez-Martin A, Gonzalez-Cortijo L, Carballo N, Garcia JF, Lapuente F, Rojo A, Chiva LM: The current role of neoadjuvant chemotherapy in the management of cervical carcinoma. Gynecol Oncol 2008; 110:S36-S40.
Han SN, Vergote I, Amant F: Weekly paclitaxel/ carboplatin in the treatment of locally advanced, recurrent, or metastatic vulvar cancer. Int J Gynecol Cancer 2012; 22: 865-868.
van Doorn HC, Ansink A, Verhaar-Langereis M, Stalpers L: Neoadjuvant chemoradiation for advanced primary vulvar cancer. Cochrane Database Syst Rev 2006; 3:CD003752.
Gadducci A, Barsotti C, Laliscia C, et al: Dosedense paclitaxel-and carboplatin-based neoadjuvant chemotherapy followed by surgery or concurrent chemo-radiotherapy in cervical cancer: a preliminary analysis. Anticancer Res 2017; 37: 1249-1255.
Benedetti Panici P, Bellati F, Pastore M, Manci N, Musella A, Pauselli S, Angelucci M, Muzii L, Angioli R: An update in neoadjuvant chemotherapy in cervical cancer. Gynecol Oncol 2007; 107:S20-S22.
Monk BJ, Sill MW, McMeekin DS, Cohn DE, Ramondetta LM, Boardman CH, Benda J, Cella D: Phase III trial of four cisplatin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcinoma: a Gynecologic Oncology Group study. J Clin Oncol 2009; 27: 4649-4655.
Belotte J, Awonuga AO, Bolinjkar R, Alexis M, Tabassum F, Deppe G: Platinum-based combination chemotherapy for the treatment of advanced-stage squamous cell carcinoma of the vulva. Obstet Gynecol 2012; 120: 458-460.
Aragona AM, Cuneo N, Soderini AH, Alcoba E, Greco A, Reyes C, Lekmann S: Tailoring the treatment of locally advanced squamous cell carcinoma of the vulva: neoadjuvant chemotherapy followed by radical surgery: results from a multicenter study. Int J Gynecol Cancer 2012; 22: 1258-1263.
Musella A, Marchetti C, Salerno L, Vertechy L, Iadarola R, Pecorella I, Panici PB: An unexpected complete remission of advanced intestinal-type vulvar adenocarcinoma after neoadjuvant chemotherapy: a case report and a literature review. Case Rep Obstet Gynecol 2013; 2013: 427141.
Deppe G, Mert I, Belotte J, Winer IS: Chemotherapy of vulvar cancer: a review. Wien Klin Wochenschr 2013; 125: 119-128.
Mert I, Guterman J, Winer IS: Neoadjuvant chemotherapy for vulvar cancer: case series from a single institution. Obstet Gynecol cases Rev 2014; 1: 1-4.
Raspagliesi F, Zanaboni F, Martinelli F, Scasso S, Laufer J, Ditto A: Role of paclitaxel and cisplatin as the neoadjuvant treatment for locally advanced squamous cell carcinoma of the vulva. J Gynecol Oncol 2014; 25: 22-29.
