Transarterial chemoembolization of hepatocellular carcinoma before liver transplantation and risk of post-transplant vascular complications: a multicentre observational cohort and propensity score-matched analysis
Sneiders, D; Boteon, A P C S; Lerut, Jet al.
2021 • In British Journal of Surgery, 108 (11), p. 1323 - 1331
Sneiders, D; Department of Surgery, Erasmus MC University Medical Center, Erasmus MC Transplant Institute, Rotterdam, Netherlands
Boteon, A P C S; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom
Lerut, J; Institute for Experimental and Clinical Research (IREC), Universite´ catholique de Louvain UCL, Brussels, Belgium
Iesari, S; Institute for Experimental and Clinical Research (IREC), Universite´ catholique de Louvain UCL, Brussels, Belgium ; Kidney Transplantation Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
Gilbo, NICHOLAS ; Université de Liège - ULiège > Département des sciences cliniques > Pathologie chirurgicale abdominale et endocrinienne ; Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
Blasi, F; Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
Laureiro, Z Larghi; Department of Surgery Science, Transplantation and HPB Unit, University Hospital Tor Vergata, Rome, Italy
Orlacchio, A; Department of General Surgery and Organ Transplantation, General Surgery and Organ Transplant Unit, Sapienza University of Rome, Umberto I Policlinic of Rome, Rome, Italy
Tisone, G; Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
Lai, Q; Department of Surgery Science, Transplantation and HPB Unit, University Hospital Tor Vergata, Rome, Italy
Pirenne, J; Department of Surgery Science, Diagnostic and Interventional Unit, University Hospital Tor Vergata, Rome, Italy
Polak, W G; Department of Surgery, Erasmus MC University Medical Center, Erasmus MC Transplant Institute, Rotterdam, Netherlands
Perera, M T P R; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom
Manzia, T M; Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
Hartog, H; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom
Transarterial chemoembolization of hepatocellular carcinoma before liver transplantation and risk of post-transplant vascular complications: a multicentre observational cohort and propensity score-matched analysis
Bekker J, Ploem S, De Jong K. Early hepatic artery thrombosis after liver transplantation: a systematic review of the incidence, outcome and risk factors. Am J Transplant 2009;9:746–757.
Mourad MM, Liossis C, Gunson BK, Mergental H, Isaac J, Muiesan P et al. Etiology and management of hepatic artery thrombosis after adult liver transplantation. Liver Transpl 2014; 20:713–723.
Oh C-K, Pelletier SJ, Sawyer RG, Dacus AR, McCullough CS, Pruett TL et al. Uni- and multi-variate analysis of risk factors for early and late hepatic artery thrombosis after liver transplantation. Transplantation 2001;71:767–772.
Silva MA, Jambulingam PS, Gunson BK, Mayer D, Buckels JA, Mirza DF et al. Hepatic artery thrombosis following orthotopic liver transplantation: a 10-year experience from a single centre in the United Kingdom. Liver Transpl 2006;12:146–151.
Stange BJ, Glanemann M, Nuessler NC, Settmacher U, Steinmüller T, Neuhaus P. Hepatic artery thrombosis after adult liver transplantation. Liver Transpl 2003;9:612–620.
Warner P, Fusai G, Glantzounis GK, Sabin CA, Rolando N, Patch D et al. Risk factors associated with early hepatic artery thrombosis after orthotopic liver transplantation – univariable and multivariable analysis. Transpl Int 2011;24:401–408.
Buis CI, Hoekstra H, Verdonk RC, Porte RJ. Causes and consequences of ischemic-type biliary lesions after liver transplantation. J Hepatobiliary Pancreat Surg 2006;13:517–524.
Heckman JT, Devera MB, Marsh JW, Fontes P, Amesur NB, Holloway SE et al. Bridging locoregional therapy for hepatocellular carcinoma prior to liver transplantation. Ann Surg Oncol 2008;15:3169–3177.
Marelli L, Stigliano R, Triantos C, Senzolo M, Cholongitas E, Davies N et al. Transarterial therapy for hepatocellular carcinoma: which technique is more effective? A systematic review of cohort and randomized studies. Cardiovasc Intervent Radiol 2007;30:6–25.
DiNorcia J, Florman SS, Haydel B, Tabrizian P, Ruiz RM, Klintmalm GB et al. Pathologic response to pretransplant locoregional therapy is predictive of patient outcome after liver transplantation for hepatocellular carcinoma: analysis from the US multicenter HCC transplant consortium. Ann Surg 2019;271: 616–624.
Manzia TM, Lai Q, Iesari S, Perera MTP, Komuta M, Carvalheiro A et al. Impact of remnant vital tissue after locoregional treatment and liver transplant in hepatocellular cancer patients, a multicentre cohort study. Transpl Int 2018;31:988–998.
Golfieri R, Cappelli A, Cucchetti A, Piscaglia F, Carpenzano M, Peri E et al. Efficacy of selective transarterial chemoembolization in inducing tumor necrosis in small (< 5 cm) hepatocellular carcinomas. Hepatology 2011;53:1580–1589.
Loffroy R, Guiu B, Cercueil J-P, Krausé D. Endovascular therapeutic embolisation: an overview of occluding agents and their effects on embolised tissues. Curr Vasc Pharmacol 2009;7: 250–263.
Dhanasekaran R, Kooby DA, Staley CA, Kauh JS, Khanna V, Kim HS. Comparison of conventional transarterial chemoembolization (TACE) and chemoembolization with doxorubicin drug eluting beads (DEB) for unresectable hepatocelluar carcinoma (HCC). J Surg Oncol 2010;101:476–480.
Xia J, Ren Z, Ye S, Sharma D, Lin Z, Gan Y et al. Study of severe and rare complications of transarterial chemoembolization (TACE) for liver cancer. Eur J Radiol 2006;59:407–412.
Malagari K, Pomoni M, Spyridopoulos TN, Moschouris H, Kelekis A, Dourakis S et al. Safety profile of sequential transcatheter chemoembolization with DC BeadTM: results of 237 hepatocellular carcinoma (HCC) patients. Cardiovasc Intervent Radiol 2011;34: 774–785.
Panaro F, Ramos J, Gallix B, Mercier G, Herrero A, Niampa H et al. Hepatic artery complications following liver transplantation. Does preoperative chemoembolization impact the postoperative course? Clin Transplant 2014;28:598–605.
Li H, Li B, Wei Y, Yan L, Wen T, Wang W et al. Preoperative transarterial chemoembolization does not increase hepatic artery complications after liver transplantation: a single center 12-year experience. Clin Res Hepatol Gastroenterol 2015;39:451–457.
Lin TS, Chiang YC, Chen CL, Concejero AM, Cheng YF, Wang CC et al. Intimal dissection of the hepatic artery following transarterial embolization for hepatocellular carcinoma: an intraoperative problem in adult living donor liver transplantation. Liver Transpl 2009;15:1553–1556.
Gilbo N, Van Praet L, Jochmans I, Sainz-Barriga M, Verslype C, Maleux G et al. Pre-operative trans-catheter arterial chemo-embolization increases hepatic artery thrombosis after liver transplantation – a retrospective study. Transpl Int 2018;31:71–81.
Sneiders D, Houwen T, Pengel LH, Polak WG, Dor FJ, Hartog H. Systematic review and meta-analysis of posttransplant hepatic artery and biliary complications in patients treated with transarterial chemoembolization before liver transplantation. Transplantation 2018;102:88–96.
Benchimol EI, Smeeth L, Guttmann A, Harron K, Moher D, Petersen I et al.; RECORD Working Committee. The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement. PLoS Med 2015;12:e1001885.
Von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP; STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med 2007;147:573–577.
Feng S, Goodrich N, Bragg-Gresham J, Dykstra D, Punch J, DebRoy M et al. Characteristics associated with liver graft failure: the concept of a donor risk index. Am J Transplant 2006;6:783–790.
Vivarelli M, Cucchetti A, La Barba G, Bellusci R, De Vivo A, Nardo B et al. Ischemic arterial complications after liver transplantation in the adult: multivariate analysis of risk factors. Arch Surg 2004;139:1069–1074.
Majno PE, Adam R, Bismuth H, Castaing D, Ariche A, Krissat J et al. Influence of preoperative transarterial lipiodol chemoembolization on resection and transplantation for hepatocellular carcinoma in patients with cirrhosis. Ann Surg 1997;226:688.
Mekeel K, Moss A, Reddy K, Byrne T, Douglas D, Naidu S et al. The risk of hepatic arterial complications associated with transarterial chemoembolization prior to liver transplantation for hepatocellular carcinoma. Transplantation 2010;90:781.
Baccarani U, Pravisani R, Adani GL, Lorenzin D, Risaliti A. Transarterial chemoembolization does not harm the hepatic artery at transplantation. Liver Transpl 2015;21:564.
Casadaban L, Malespin M, Cheung A, McGuffey R, Boulay B, Halline A et al. Presurgical transarterial chemoembolization does not increase biliary stricture incidence in orthotopic liver transplant patients. Transplant Proc 2014;46:1413–1419.
Goel A, Mehta N, Guy J, Fidelman N, Yao F, Roberts J et al. Hepatic artery and biliary complications in liver transplant recipients undergoing pretransplant transarterial chemoembolization. Liver Transpl 2014;20:1221–1228.
Kanakadandi V, Park J, Ahmad J. Chemoembolization therapy of hepatocellular carcinoma prior to liver transplant is associated with the development of post-transplant biliary anastomotic strictures. Hepatology 2012;56.
Ramanathan M, Pedersen M, Choi M, Seetharam A. Downstaging or bridging therapy of hepatocellular cancer does not increase incidence of biliary complications after liver transplantation. Hepatology 2015;62.
Richard HM, Silberzweig JE, Mitty HA, Lou WY, Ahn J, Cooper JM. Hepatic arterial complications in liver transplant recipients treated with pretransplantation chemoembolization for hepatocellular carcinoma. Radiology 2000;214:775–779.
Saborido BP, Meneu JC, Moreno E, García I, Moreno A, Fundora Y. Is transarterial chemoembolization necessary before liver transplantation for hepatocellular carcinoma? Am J Surg 2005; 190:383–387.
Shiani A, Rodriguez A, Lipka S, Sethi S, Nehaul R, Chirumamilla S. Vascular complications after transarterial chemoembolization in orthotopic liver transplant patients. Am J Gastroenterol 2015;110: 475A–476A.
Wallace D, Cowling T, Walker K, Suddle A, Gimson A, Rowe I et al. Liver transplantation outcomes after transarterial chemotherapy for hepatocellular carcinoma. Br J Surg 2020;107:1183–1191.
Kulik L, Heimbach JK, Zaiem F, Almasri J, Prokop LJ, Wang Z et al. Therapies for patients with hepatocellular carcinoma awaiting liver transplantation: a systematic review and meta-analysis. Hepatology 2018;67:381–400.
Gordon-Weeks A, Snaith A, Petrinic T, Friend P, Burls A, Silva M. Systematic review of outcome of downstaging hepatocellular cancer before liver transplantation in patients outside the Milan criteria. Br J Surg 2011;98:1201–1208.
Lai Q, Vitale A, Iesari S, Finkenstedt A, Mennini G, Spoletini G et al.; European Hepatocellular Cancer Liver Transplant Study Group. Intention-to-treat survival benefit of liver transplantation in patients with hepatocellular cancer. Hepatology 2017;66: 1910–1919.
Mehta N, Yao FY. What are the optimal liver transplantation criteria for hepatocellular carcinoma? Clin Liver Dis (Hoboken) 2019; 13:20–25.
Borner M, Castiglione M, Triller J, Baer H, Soucek M, Blumgart L et al. Considerable side effects of chemoembolization for colorectal carcinoma metastatic to the liver. Ann Oncol 1992;3: 113–115.
Daniels JR, Kerlan RK, Dodds L, McLaughlin P, LaBerge JM, Harrington D et al. Peripheral hepatic arterial embolization with crosslinked collagen fibers. Invest Radiol 1987;22: 126–131.
