Article (Scientific journals)
Value of staging squamous cell carcinoma of the anal margin and canal using the sentinel lymph node procedure: An update of the series and a review of the literature
Mistrangelo, D M; Bellò, M; Cassoni, P et al.
2013In British Journal of Cancer, 108 (3), p. 527 - 532
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Abstract :
[en] Background: Inguinal metastases in patients affected by anal cancer are an independent prognostic factor for local failure and overall mortality. Since 2001, sentinel lymph node biopsy was applied in these patients. This original study reports an update of personal and previous published series, which were compared with Literature to value the incidence of inguinal metastases T-stage related and the overall incidence of false negative inguinal metastases at sentinel node. Methods: In all, 63 patients diagnosed with anal cancer submitted to inguinal sentinel node. Furthermore a research in the Pub Med database was performed to find papers regarding this technique. Results: In our series, detection rate was 98.4%. Inguinal metastases were evidentiated in 13 patients (20.6%). Our median follow-up was 35 months. In our series, no false negative nodes were observed. Conclusion: Sentinel node technique in the detection of inguinal metastases in patients affected by anal cancer should be considered as a standard of care. It is indicated for all T stages in order to select patients to be submitted to inguinal radiotherapy, avoiding related morbidity in negative ones. An overall 3.7% rate of false negative must be considered acceptable. © 2013 Cancer Research UK. All rights reserved.
Disciplines :
Surgery
Author, co-author :
Mistrangelo, D M;  Digestive and Colorectal Surgical Department, University of Turin, Molinette Hospital, Turin, Italy
Bellò, M;  Department of Nuclear Medicine, University of Turin, Molinette Hospital, Turin, Italy
Cassoni, P;  Department of Biomedical Sciences and Human Oncology, University of Turin, Molinette Hospital, Turin, Italy
Milanesi, E;  Oncological Centre for Gastrointestinal Neoplasms, Molinette Hospital, Turin, Italy
Racca, P;  Oncological Centre for Gastrointestinal Neoplasms, Molinette Hospital, Turin, Italy
Munoz, F;  Department of Radiotherapy, University of Turin, Molinette Hospital, Turin, Italy
Fora, G;  Oncological Centre for Gastrointestinal Neoplasms, Molinette Hospital, Turin, Italy
Rondi, N;  Department of Radiotherapy, University of Turin, Molinette Hospital, Turin, Italy
Gilbo, NICHOLAS  ;  Université de Liège - ULiège > Département des sciences cliniques > Pathologie chirurgicale abdominale et endocrinienne ; Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
Senetta, R;  Department of Biomedical Sciences and Human Oncology, University of Turin, Molinette Hospital, Turin, Italy
Ricardi, U;  Department of Radiotherapy, University of Turin, Molinette Hospital, Turin, Italy
Morino, M;  Digestive and Colorectal Surgical Department, University of Turin, Molinette Hospital, Turin, Italy
Language :
English
Title :
Value of staging squamous cell carcinoma of the anal margin and canal using the sentinel lymph node procedure: An update of the series and a review of the literature
Publication date :
2013
Journal title :
British Journal of Cancer
ISSN :
0007-0920
eISSN :
1532-1827
Publisher :
Nature Publishing Group, Gb
Volume :
108
Issue :
3
Pages :
527 - 532
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 January 2024

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