Intensified Continuous Flow Process for the Scalable Production of Bio-Based Glycerol Carbonate.

[en] A subtle combination of fundamental and applied organic chemistry toward process intensification is demonstrated for the large-scale production of bio-based glycerol carbonate under flow conditions. The direct carbonation of bio-based glycidol with CO2 is successfully carried out under intensified flow conditions, with Barton's base as a potent homogeneous organocatalyst. Process metrics for the CO2 coupling step (for the upstream production, output: 3.6 kg day-1, Space Time Yield (STY): 2.7 kg h-1 L-1, Environmental factor (E-factor): 4.7) outclass previous reports. High conversion and selectivity are achieved in less than 30 s of residence time at pilot scale with a stoichiometric amount of CO2. Supporting DFT computations reveal the unique features of the mechanism in presence of Brønsted bases.

Research Center/Unit :

Center for Integrated Technology and Organic Synthesis (CiTOS)
Center for Education and Research on Macromolecules (CERM)
MolSys Research Unit
CESAM Research Unit

Disciplines :

Chemistry

Author, co-author :

Muzyka, Claire ; Université de Liège - ULiège > Molecular Systems (MolSys)

Renson, Sébastien ; Université de Liège - ULiège > Molecular Systems (MolSys)

Grignard, Bruno ; Université de Liège - ULiège > Département de chimie (sciences) > Centre d'études et de recherches sur les macromolécules (CERM)

Detrembleur, Christophe ; Université de Liège - ULiège > Département de chimie (sciences) > Centre d'études et de recherches sur les macromolécules (CERM)

Monbaliu, Jean-Christophe ; Université de Liège - ULiège > Molecular Systems (MolSys)

Language :

English

Title :

Intensified Continuous Flow Process for the Scalable Production of Bio-Based Glycerol Carbonate.

Publication date :

10 January 2024

Journal title :

Angewandte Chemie International Edition

ISSN :

1433-7851

eISSN :

1521-3773

Publisher :

Wiley, Germany

Pages :

e202319060

Peer reviewed :

Peer Reviewed verified by ORBi

Tags :

CÉCI : Consortium des Équipements de Calcul Intensif
FloW4all - Flow Technology Research Center
Tier-1 supercomputer

Additional URL :

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202319060

Available on ORBi :

since 24 January 2024

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