Article (Scientific journals)
Intensified Continuous Flow Process for the Scalable Production of Bio-Based Glycerol Carbonate.
Muzyka, Claire; Renson, Sébastien; Grignard, Bruno et al.
2024In Angewandte Chemie International Edition, p. 202319060
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Keywords :
Bio-based chemicals; CO2; Continuous flow; Glycerol carbonate; Intensification; General Chemistry; Catalysis
Abstract :
[en] A subtle combination of fundamental and applied organic chemistry toward process intensification is demonstrated for the large-scale production of bio-based glycerol carbonate under flow conditions. The direct carbonation of bio-based glycidol with CO2 is successfully carried out under intensified flow conditions, with Barton's base as a potent homogeneous organocatalyst. Process metrics for the CO2 coupling step (for the upstream production, output: 3.6 kg day-1, Space Time Yield (STY): 2.7 kg h-1 L-1, Environmental factor (E-factor): 4.7) outclass previous reports. High conversion and selectivity are achieved in less than 30 s of residence time at pilot scale with a stoichiometric amount of CO2. Supporting DFT computations reveal the unique features of the mechanism in presence of Brønsted bases.
Research center :
Center for Integrated Technology and Organic Synthesis (CiTOS)
Center for Education and Research on Macromolecules (CERM)
MolSys Research Unit
CESAM Research Unit
Consortium des Équipements de Calcul Intensif (CÉCI)
Disciplines :
Chemistry
Author, co-author :
Muzyka, Claire ;  Université de Liège - ULiège > Molecular Systems (MolSys)
Renson, Sébastien  ;  Université de Liège - ULiège > Molecular Systems (MolSys)
Grignard, Bruno ;  Université de Liège - ULiège > Département de chimie (sciences) > Centre d'études et de recherches sur les macromolécules (CERM)
Detrembleur, Christophe ;  Université de Liège - ULiège > Département de chimie (sciences) > Centre d'études et de recherches sur les macromolécules (CERM)
Monbaliu, Jean-Christophe  ;  Université de Liège - ULiège > Molecular Systems (MolSys)
Language :
English
Title :
Intensified Continuous Flow Process for the Scalable Production of Bio-Based Glycerol Carbonate.
Publication date :
10 January 2024
Journal title :
Angewandte Chemie International Edition
ISSN :
1433-7851
eISSN :
1521-3773
Publisher :
Wiley, Germany
Pages :
e202319060
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 January 2024

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