Article (Scientific journals)
Streptococcus agalactiae infective endocarditis: analysis of eight surgical cases from a single centre.
Tchana-Sato, Vincent; Hans, Grégory; FRIPPIAT, Frédéric et al.
2021In Infectious Diseases, 53 (3), p. 189 - 195
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Keywords :
Streptococcus agalactiae; Infective endocarditis; cardiac surgery; Adult; Aged; Female; Humans; Male; Middle Aged; Retrospective Studies; Endocarditis/surgery; Endocarditis, Bacterial/drug therapy; Endocarditis, Bacterial/epidemiology; Endocarditis, Bacterial/surgery; Streptococcal Infections/epidemiology; Endocarditis; Endocarditis, Bacterial; Streptococcal Infections; Immunology and Microbiology (all); Microbiology (medical); Infectious Diseases; General Immunology and Microbiology; General Medicine
Abstract :
[en] [en] BACKGROUND: Streptococcus agalactiae (GBS) infective endocarditis (IE) is a rare clinical entity. It is associated with a high mortality rate compared to other streptococci endocarditis. The aim of this study is to define the clinical characteristics, treatment and outcomes of a series of eight non-pregnant adults with GBS IE managed by a combination of antibiotics and surgery at our institution. METHODS: We retrospectively reviewed the medical records of all adult patients with a definite diagnosis of IE by Duke modified criteria and who underwent surgery at our centre between January 2008 and December 2018. RESULTS: A total of 190 patients underwent surgery for IE during the study period. Eight cases of GBS IE were identified, including six males and two females. The mean aged was 54 years (range, 32-68). Seven cases suffered native valve endocarditis and one involved an aortic bioprosthesis. Seven patients had underlying comorbidities. Furthermore, four patients had experienced serious complications. Of these, the most common were heart failure, septic shock, and cerebral emboli. Vegetations tended to be large, very mobile, and pedunculated. Most of the patients were treated with penicillin plus an aminoglycoside. Surgery was emergently performed in one patient and urgently performed in seven patients. In- hospital mortality rate was 37.5%. CONCLUSION: GBS IE is a virulent disease with an aggressive clinical course. It mostly affects patients with debilitating diseases. Early surgery should be considered to prevent the development of serious complications. However, overall mortality rate remains high despite surgical treatment.
Disciplines :
Cardiovascular & respiratory systems
Immunology & infectious disease
Surgery
Author, co-author :
Tchana-Sato, Vincent  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique
Hans, Grégory ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'anesthésie - réanimation
FRIPPIAT, Frédéric  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des maladies infectieuses - médecine interne
ZEKHNINI, Inès ;  Centre Hospitalier Universitaire de Liège - CHU > > Frais communs chirurgie
Dulgheru, Raluca Elena ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de cardiologie
Brüls, Samuel  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique
Durieux, Rodolphe  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique
LAVIGNE, Jean-Paul ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique
Defraigne, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique
Language :
English
Title :
Streptococcus agalactiae infective endocarditis: analysis of eight surgical cases from a single centre.
Publication date :
March 2021
Journal title :
Infectious Diseases
ISSN :
2374-4235
eISSN :
2374-4243
Publisher :
Taylor and Francis Ltd., England
Volume :
53
Issue :
3
Pages :
189 - 195
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 January 2024

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