[en] Based on the findings of a recent study suggesting a decreased cold-induced ascites incidence in broiler progeny from hyperthyroid (HYPER) breeder hens, and a controversy on the effects of hyperthyroidism on immunocompetence, the present study was conducted to determine the probable adverse effect of induced maternal hyperthyroidism on immune function in progeny chicks. Breeder hens (n = 88) were randomly allotted to the control or HYPER groups and received common or thyroxine (T4)-added (1 mg/L) water, respectively. The hens were artificially inseminated, and hatching eggs (n = 924) were incubated. Thereafter, the male hatchlings (n = 288) were reared for 42 d, and several cellular and humoral immune responses were evaluated at standard or low ambient temperature. Prevaccination antibody titers to Newcastle disease, infectious bronchitis, and infectious bursal disease virus were higher in HYPER chicks during 1 wk of age, although not different in their dams. For primary response to SRBC administered at 7 d of age, HYPER chicks recorded higher total, IgM (d 14), and IgG (d 21) anti-SRBC antibody titers. Higher cutaneous basophilic hypersensitivity response in HYPER chicks (d 10) was not observed at 35 d of age. Carbon clearance assay showed no difference, but in vitro lymphoproliferative response to concanavalin A was higher in 19-d-old HYPER chicks, independent of temperature treatment. An increase in lymphocyte percentage coincided with a decreased heterophil percentage and heterophil to lymphocyte ratio (d 14) in the HYPER group. The weight of lymphoid organs in progeny was not influenced by the oral exposure of dams to extra T4. Independent of T4 treatment, cold exposure was generally associated with decreased immune functions at early stages. The data suggested that oral exposure of broiler breeder hens to 1 mg/L of T4 not only had no adverse effect on immune function, but also modulated early adaptive immune responses in progeny chicks for which the causal mechanisms remain to be unraveled.
Disciplines :
Animal production & animal husbandry
Author, co-author :
Akhlaghi, A; Department of Animal Science, Shiraz University, Shiraz, Iran. aakhlaghi@shirazu.ac.ir
Zamiri, M J; Department of Animal Science, College of Agriculture, Shiraz University, 71441-65186 Shiraz, Iran
Jafari Ahangari, Y; Gorgan University of Agricultural Science and Natural Resources, 49189-43464 Gorgan, Iran
Atashi, Hadi ; Université de Liège - ULiège > Département GxABT > Animal Sciences (AS) ; Department of Animal Science, College of Agriculture, Shiraz University, 71441-65186 Shiraz, Iran
Ansari Pirsaraei, Z; Department of Animal Science, Sari Agricultural Sciences and Natural Resources University, 48177-36781 Sari, Iran
Deldar, H; Department of Animal Science, Sari Agricultural Sciences and Natural Resources University, 48177-36781 Sari, Iran
Eghbalian, A N; Babolkenar Arian Line Breeding Center, 47561-64397 Babolkenar, Iran
Akhlaghi, A A; Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, 21889-89127 Tehran, Iran
Navidshad, B; Department of Animal Science, University of Mohaghegh Ardabili, 56199-11367 Ardabil, Iran
Yussefi Kelarikolaei, K; Babolkenar Arian Line Breeding Center, 47561-64397 Babolkenar, Iran
Hashemi, S R; Gorgan University of Agricultural Science and Natural Resources, 49189-43464 Gorgan, Iran
Language :
English
Title :
Oral exposure of broiler breeder hens to extra thyroxine modulates early adaptive immune responses in progeny chicks.
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