[en] Based on the findings of a recent study suggesting a decreased cold-induced ascites incidence in broiler progeny from hyperthyroid (HYPER) breeder hens, and a controversy on the effects of hyperthyroidism on immunocompetence, the present study was conducted to determine the probable adverse effect of induced maternal hyperthyroidism on immune function in progeny chicks. Breeder hens (n = 88) were randomly allotted to the control or HYPER groups and received common or thyroxine (T4)-added (1 mg/L) water, respectively. The hens were artificially inseminated, and hatching eggs (n = 924) were incubated. Thereafter, the male hatchlings (n = 288) were reared for 42 d, and several cellular and humoral immune responses were evaluated at standard or low ambient temperature. Prevaccination antibody titers to Newcastle disease, infectious bronchitis, and infectious bursal disease virus were higher in HYPER chicks during 1 wk of age, although not different in their dams. For primary response to SRBC administered at 7 d of age, HYPER chicks recorded higher total, IgM (d 14), and IgG (d 21) anti-SRBC antibody titers. Higher cutaneous basophilic hypersensitivity response in HYPER chicks (d 10) was not observed at 35 d of age. Carbon clearance assay showed no difference, but in vitro lymphoproliferative response to concanavalin A was higher in 19-d-old HYPER chicks, independent of temperature treatment. An increase in lymphocyte percentage coincided with a decreased heterophil percentage and heterophil to lymphocyte ratio (d 14) in the HYPER group. The weight of lymphoid organs in progeny was not influenced by the oral exposure of dams to extra T4. Independent of T4 treatment, cold exposure was generally associated with decreased immune functions at early stages. The data suggested that oral exposure of broiler breeder hens to 1 mg/L of T4 not only had no adverse effect on immune function, but also modulated early adaptive immune responses in progeny chicks for which the causal mechanisms remain to be unraveled.
Disciplines :
Animal production & animal husbandry
Author, co-author :
Akhlaghi, A; Department of Animal Science, Shiraz University, Shiraz, Iran. aakhlaghi@shirazu.ac.ir
Zamiri, M J; Department of Animal Science, College of Agriculture, Shiraz University, 71441-65186 Shiraz, Iran
Jafari Ahangari, Y; Gorgan University of Agricultural Science and Natural Resources, 49189-43464 Gorgan, Iran
Atashi, Hadi ; Université de Liège - ULiège > Département GxABT > Animal Sciences (AS) ; Department of Animal Science, College of Agriculture, Shiraz University, 71441-65186 Shiraz, Iran
Ansari Pirsaraei, Z; Department of Animal Science, Sari Agricultural Sciences and Natural Resources University, 48177-36781 Sari, Iran
Deldar, H; Department of Animal Science, Sari Agricultural Sciences and Natural Resources University, 48177-36781 Sari, Iran
Eghbalian, A N; Babolkenar Arian Line Breeding Center, 47561-64397 Babolkenar, Iran
Akhlaghi, A A; Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, 21889-89127 Tehran, Iran
Navidshad, B; Department of Animal Science, University of Mohaghegh Ardabili, 56199-11367 Ardabil, Iran
Yussefi Kelarikolaei, K; Babolkenar Arian Line Breeding Center, 47561-64397 Babolkenar, Iran
Hashemi, S R; Gorgan University of Agricultural Science and Natural Resources, 49189-43464 Gorgan, Iran
Language :
English
Title :
Oral exposure of broiler breeder hens to extra thyroxine modulates early adaptive immune responses in progeny chicks.
Akhlaghi, A., M. J. Zamiri, A. Zare Shahneh, Y. Jafari Ahangari, A. Nejati Javaremi, G. Rahimi Mianji, M. R. Mollasalehi, H. Shojaie, A. A. Akhlaghi, H. Deldar, H. Atashi, Z. Ansari Pirsaraei, and M. Zhandi. 2012. Maternal hyperthyroidism is associated with a decreased incidence of cold-induced ascites in broiler chickens. Poult. Sci. 91:1165-1172.
Bachman, S. E., and M. M. Mashaly. 1987. Relationship between circulating thyroid hormones and cell-mediated immunity in immature male chickens. Dev. Comp. Immunol. 11:203-213.
Buitenhuis, A. J., J. B. Kjaer, R. Labouriau, and H. R. Juul-Madsen. 2006. Altered circulating levels of serotonin and immunological changes in laying hens divergently selected for feather pecking behavior. Poult. Sci. 85:1722-1728.
Darbyshire, J. H., and R. W. Peters. 1985. Humoral antibody response and assessment of protection following primary vaccination of chicks with maternally derived antibody against avian infectious bronchitis virus. Res. Vet. Sci. 38:14-21.
Davison, F., K. E. Magor, and B. Kaspers. 2008. Structure and evolution of avian immunoglobulins. Pages 107-127 in Avian Immunology. F. Davison, B. Kaspers, and K. A. Schat, ed. Academic Press, London, UK.
Dohms, J. E., and A. Metz. 1991. Stress-Mechanisms of immunosuppression. Vet. Immunol. Immunopathol. 30:89-109.
Fabris, N. 1973. Immunodepression in thyroid-deprived animals. Clin. Exp. Immunol. 15:601-611.
Fabris, N., E. Mocchegiani, and M. Provinciali. 1995. Pituitarythyroid axis and immune system: A reciprocal neuroendocrineimmune interaction. Horm. Res. 43:29-38.
Fahey, K. J., J. K. Crooks, and R. A. Fraser. 1987. Assessment by ELISA of passively acquired protection against infectious bursal disease virus in chickens. Aust. Vet. J. 64:203-207.
Glick, B. 1984. Interrelation of the avian immune and neuroendocrine systems. J. Exp. Zool. 232:671-682.
Goodman, H. M. 2003. Basic Medical Endocrinology. Raven Press, New York, NY.
Griffin, J. F. 1989. Stress and immunity: A unifying concept. Vet. Immunol. Immunopathol. 20:263-312.
Guo, S., N. H. Chen, R. Guan, J. Feng, and W. Huang. 2006. Effects of anti-bursin monoclonal antibody on immunosuppression in the duck (Cherry Valley duck). Poult. Sci. 85:258-265.
Gupta, M. K., T. Chiang, and S. D. Deodhar. 1983. Effect of thyroxine on immune response in C57B1/6J mice. Acta Endocrinol. (Copenh.) 103:76-80.
Hamal, K. R., S. C. Burgess, I. Y. Pevzner, and G. F. Erf. 2006. Maternal antibody transfer from dams to their egg yolks, egg whites, and chicks in meat lines of chickens. Poult. Sci. 85:1364-1372.
Hangalapura, B. N., M. G. Nieuwland, J. Buyse, B. Kemp, and H. K. Parmentier. 2004a. Effect of duration of cold stress on plasma adrenal and thyroid hormone levels and immune responses in chicken lines divergently selected for antibody responses. Poult. Sci. 83:1644-1649.
Hangalapura, B. N., M. G. Nieuwland, G. de Vries Reilingh, M. J. Heetkamp, H. van den Brand, B. Kemp, and H. K. Parmentier. 2003. Effects of cold stress on immune responses and body weight of chicken lines divergently selected for antibody responses to sheep red blood cells. Poult. Sci. 82:1692-1700.
Hangalapura, B. N., M. G. Nieuwland, G. de Vries Reilingh, H. van den Brand, B. Kemp, and H. K. Parmentier. 2004b. Durations of cold stress modulates overall immunity of chicken lines divergently selected for antibody responses. Poult. Sci. 83:765-775.
Kaleta, E. F., O. Siegmann, K. W. Lai, and D. Aussum. 1977. Kinetics of NDV-specific antibodies in chickens. VI. Elimination of maternal and injected antibodies. Berl. Munch. Tierarztl. Wochenschr. 90:131-134.
Klecha, A. J., A. M. Genaro, G. Gorelik, M. L. Barreiro Arcos, D. M. Silberman, M. Schuman, S. I. Garcia, C. Pirola, and G. A. Cremaschi. 2006. Integrative study of hypothalamus-pituitarythyroid-immune system interaction: Thyroid hormone-mediated modulation of lymphocyte activity through the protein kinase C signaling pathway. J. Endocrinol. 189:45-55.
Koutsos, E. A., and V. J. Arias. 2006. Intestinal ecology: Interactions among the gastrointestinal tract, nutrition, and the microflora. J. Appl. Poult. Res. 15:161-173.
Li, Z., K. E. Nestor, Y. M. Saif, J. W. Anderson, and R. A. Patterson. 2001. Effect of selection for increased body weight in turkeys on lymphoid organ weights, phagocytosis, and antibody responses to fowl cholera and Newcastle disease-inactivated vaccines. Poult. Sci. 80:689-694.
Loeken, M. R., and T. F. Roth. 1983. Analysis of maternal IgG subpopulations which are transported into the chicken oocyte. Immunology 49:21-28.
Luger, D., D. Shinder, and S. Yahav. 2002. Hyper-or hypothyroidism: Its association with the development of ascites syndrome in fast-growing chickens. Gen. Comp. Endocrinol. 127:293-299.
Martin, A., F. M. A. McNabb, and P. B. Siegel. 1988. Thyroid hormones and antibody response to sheep erythrocytes of dwarf and normal chickens selected for juvenile body weight. Genet. Sel. Evol. 20:499-510.
McNabb, F. M. A. 2002. Maternal thyroid hormones in avian eggs: Potential for disruption of thyroid hormone deposition and effects on embryonic development. Pages 219-230 in Avian Endocrinology, A. Dawson and C. M. Chaturvedi, ed. Narosa Publishing House, New Delhi, India.
NRC. 1994. Nutrient Requirements of Poultry. 9th rev. ed. NRC, New York, NY.
Qureshi, M. A., J. Brake, P. B. Hamilton, W. M. Hagler, and S. Nesheim. 1998. Dietary exposure of broiler breeders to aflatoxin results in immune dysfunction in progeny chicks. Poult. Sci. 77:812-819.
Qureshi, M. A., and G. B. Havenstein. 1994. A comparison of the immune performance of a 1991 commercial broiler with a 1957 randombred strain when fed "typical" 1957 and 1991 broiler diets. Poult. Sci. 73:1805-1812.
SAS. 2002. User's Guide. SAS Institute Inc., Cary, NC.
Silberman, D. M., M. Wald, and A. M. Genaro. 2002. Effects of chronic mild stress on lymphocyte proliferative response. Participation of serum thyroid hormones and corticosterone. Int. Immunopharmacol. 2:487-497.
Singh, H., D. S. Sodhi, and R. Kaur. 2006. Effects of dietary supplements of selenium, vitamin E or combinations of the two on antibody responses of broilers. Br. Poult. Sci. 47:714-719.
Torres, K. A. A. 2006. Influência do estresse térmico no nascedouro sobre a imunidade humoral e as características zootécnicas de frangos de corte. MSc Thesis. Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, São Paulo, Brazil.
Ubosi, C. O., W. B. Gross, and P. B. Siegel. 1985. Divergent selection of chickens for antibody production to sheep erythrocytes: Age effect in parental lines and their crosses. Avian Dis. 29:150-158.
Weetman, A. P., A. M. McGregor, M. Ludgate, and R. Hall. 1984. Effect of tri-iodothyronine on normal human lymphocyte function. J. Endocrinol. 101:81-86.
