Article (Scientific journals)
NF-kappa B activation by reactive oxygen species: Fifteen years later
Gloire, Geoffrey; Legrand-Poels, Sylvie; Piette, Jacques
2006In Biochemical Pharmacology, 72 (11), p. 1493-1505
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Keywords :
NF-kappa B; reactive oxygen species; cellular signalling; cytokines; LPS
Abstract :
[en] The transcription factor NF-kappa B plays a major role in coordinating innate and adaptative immunity, cellular proliferation, apoptosis and development. Since the discovery in 1991 that NF-kappa B maybe activated by H(2)o(2), several laboratories have put a considerable effort into dissecting the molecular mechanisms underlying this activation. Whereas early studies revealed an atypical mechanism of activation, leading to I kappa B alpha Y42 phosphorylation independently Of I kappa B kinase (IKK), recent findings suggest that H2O2 activates NF-kappa B mainly through the classical IKK-dependent pathway. The molecular mechanisms leading to IKK activation are, however, cell-type specific and will be presented here. In this review, we also describe the effect of other ROS (HOCl and O-1(2)) and reactive nitrogen species on NF-kappa B activation. Finally, we critically review the recent data highlighting the role of ROS in NF-kappa B activation by proinflammatory cytokines (TNF-alpha and IL-1 beta) and lipopolysaccharide (LPS), two major components of innate immunity. (c) 2006 Elsevier Inc. All rights reserved.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Gloire, Geoffrey ;  Université de Liège - ULiège > Virologie - Immunologie
Legrand-Poels, Sylvie ;  Université de Liège - ULiège > GIGA-R : Virologie - Immunologie
Piette, Jacques ;  Université de Liège - ULiège > Département des sciences de la vie > Virologie - Immunologie
Language :
English
Title :
NF-kappa B activation by reactive oxygen species: Fifteen years later
Publication date :
30 November 2006
Journal title :
Biochemical Pharmacology
ISSN :
0006-2952
eISSN :
1873-2968
Publisher :
Pergamon-Elsevier Science Ltd, Oxford, United Kingdom
Volume :
72
Issue :
11
Pages :
1493-1505
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
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