NF-kappa B activation by reactive oxygen species: Fifteen years later

[en] The transcription factor NF-kappa B plays a major role in coordinating innate and adaptative immunity, cellular proliferation, apoptosis and development. Since the discovery in 1991 that NF-kappa B maybe activated by H(2)o(2), several laboratories have put a considerable effort into dissecting the molecular mechanisms underlying this activation. Whereas early studies revealed an atypical mechanism of activation, leading to I kappa B alpha Y42 phosphorylation independently Of I kappa B kinase (IKK), recent findings suggest that H2O2 activates NF-kappa B mainly through the classical IKK-dependent pathway. The molecular mechanisms leading to IKK activation are, however, cell-type specific and will be presented here. In this review, we also describe the effect of other ROS (HOCl and O-1(2)) and reactive nitrogen species on NF-kappa B activation. Finally, we critically review the recent data highlighting the role of ROS in NF-kappa B activation by proinflammatory cytokines (TNF-alpha and IL-1 beta) and lipopolysaccharide (LPS), two major components of innate immunity. (c) 2006 Elsevier Inc. All rights reserved.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Gloire, Geoffrey ; Université de Liège - ULiège > Virologie - Immunologie

Legrand-Poels, Sylvie ; Université de Liège - ULiège > GIGA-R : Virologie - Immunologie

Piette, Jacques ; Université de Liège - ULiège > Département des sciences de la vie > Virologie - Immunologie

Language :

English

Title :

NF-kappa B activation by reactive oxygen species: Fifteen years later

Publication date :

30 November 2006

Journal title :

Biochemical Pharmacology

ISSN :

0006-2952

eISSN :

1873-2968

Publisher :

Pergamon-Elsevier Science Ltd, Oxford, United Kingdom

Volume :

Issue :

Pages :

1493-1505

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 18 February 2010

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