[en] To assess the acute toxicity and hence feasibility of postoperative hyperfractionated accelerated radiotherapy in rectal cancer. METHODS AND MATERIALS: Twenty patients were submitted to accelerated hyperfractionated radiotherapy after resection of rectal cancer. A total dose of 48 Gy was given in 3 weeks. Two fractions of 1.6 Gy were used with a mean interfraction interval of at least 6 hours. The pelvic volume was treated by a four-field box technique using a linear accelerator (6-18 MV). Acute toxicity was assessed once per week. Small bowel and skin toxicity were scored according to the criteria of the World Health Organization. Bladder toxicity was scored according to the criteria of the Radiation Therapy Oncology Group. RESULTS: All the patients underwent the treatment as planned except one. No patient presented grade 3 or 4 bladder toxicity. There was only one patient who complained from grade 3 skin toxicity at the end of the treatment. Fourteen patients had some degree of intestinal toxicity. This was the most frequently occurring acute side-effect. Only two out of the fourteen patients had intestinal toxicity exceeding grade 2. CONCLUSION: Hyperfractionated accelerated radiotherapy on a pelvic volume is feasible [fr] évaluer la toxicité aiguë, et donc la faisabilité de la radiothérapie postopératoire hyperfractionnée accélérée dans le cancer du rectum. METHODS AND MATERIALS: Twenty patients were submitted to accelerated hyperfractionated radiotherapy after resection of rectal cancer. METHODES ET MATERIAUX: Vingt patients ont été soumis à la radiothérapie hyperfractionnée s'est accélérée après la résection du cancer du rectum. A total dose of 48 Gy was given in 3 weeks. Une dose totale de 48 Gy a été donnée dans 3 semaines. Two fractions of 1.6 Gy were used with a mean interfraction interval of at least 6 hours. Deux fractions de 1,6 Gy ont été utilisées avec un intervalle de interfraction moyenne d'au moins 6 heures. The pelvic volume was treated by a four-field box technique using a linear accelerator (6-18 MV). Le volume du bassin a été traitée par quatre technique de la boîte champ à l'aide d'un accélérateur linéaire (6-18 MV). Acute toxicity was assessed once per week. Toxicité aiguë a été évalué une fois par semaine. Small bowel and skin toxicity were scored according to the criteria of the World Health Organization. L'intestin grêle et une toxicité cutanée ont été notés selon les critères de l'Organisation mondiale de la santé. Bladder toxicity was scored according to the criteria of the Radiation Therapy Oncology Group. La toxicité de la vessie a été noté selon les critères du Radiation Therapy Oncology Group. RESULTS: All the patients underwent the treatment as planned except one. RÉSULTATS: Tous les patients ont suivi le traitement comme prévu, sauf une. No patient presented grade 3 or 4 bladder toxicity. Aucun patient n'a présenté de grade 3 ou 4 de toxicité de la vessie. There was only one patient who complained from grade 3 skin toxicity at the end of the treatment. Il y avait seulement un patient qui se plaint d'une toxicité cutanée de grade 3 à la fin du traitement. Fourteen patients had some degree of intestinal toxicity. Quatorze patients avaient un certain degré de toxicité intestinale. This was the most frequently occurring acute side-effect. C'était le côté aiguë la plus fréquente-effet. Only two out of the fourteen patients had intestinal toxicity exceeding grade 2. Seuls deux des quatorze patients avaient une toxicité intestinale supérieure à la 2e année. CONCLUSION: Hyperfractionated accelerated radiotherapy on a pelvic volume is feasible as far as acute toxicity is concerned. CONCLUSION: La radiothérapie accélérée hyperfractionnée sur un volume pelvien est réalisable dans la mesure que la toxicité aiguë est concernée.
Disciplines :
Oncology
Author, co-author :
Coucke, Philippe ; Centre Hospitalier Universitaire Vaudois > Radiation-Oncology
Cuttat, J-F; Centre Hospitalier Universitaire Vaudois > Radiation-Oncology
Mirimanoff, R-O; Centre Hospitalier Universitaire Vaudois > Radiation-Oncology
Language :
English
Title :
Adjuvant postoperative accelerated hyperfractionated radiotherapy in rectal cancer : a feasability study
Alternative titles :
[fr] Adjuvant postopératoire accélérée hyperfractionnée radiothérapie dans les cancers du rectum: une étude de faisabilité
Publication date :
November 1993
Journal title :
International Journal of Radiation, Oncology, Biology, Physics
ISSN :
0360-3016
eISSN :
1879-355X
Publisher :
Elsevier Science, Tarrytown, United States - New York
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