Ethanol; Behavioral sensitization; Locomotor activity; Environmental enrichment; Social enrichment; Social isolation; Mice
Abstract :
[en] Rationale. In previous animal model studies, it was shown that drug sensitization is dependent upon physical environmental conditions. However, the effects of social housing conditions on drug sensitization is much less known.
Objective. The aim of the present study was to investigate the effects of social conditions, through the size of housing groups, on ethanol stimulant effects and ethanol-induced behavioral sensitization in mice.
Materials and methods. Male and female Swiss mice were housed in groups of different sizes (isolated mice, two mice per cage, four mice per cage and eight mice per cage) during a six-week period. A standard paradigm of ethanol-induced locomotor sensitization was then started with one daily injection of 2.5 g/kg ethanol for 8 consecutive days.
Results. The results show that social housing conditions affect the acute stimulant effects of ethanol. The highest stimulant effects were observed in socially isolated mice and then gradually decreased as the size of the group increased. Although the rate of ethanol sensitization did not differ between groups, the ultimate sensitized levels of ethanol-induced stimulant effects were significantly reduced in mice housed in groups of eight.
Conclusions. These results are consistent with the idea that higher levels of acute and sensitized ethanol stimulant effects are observed in mice housed in stressful housing conditions, such as social isolation. [fr] Contexte. Dans des études antérieures sur les modèles animaux, il a été démontré que la sensibilisation aux substances dépend des conditions environnementales physiques. Cependant, les effets des conditions d'hébergement social sur la sensibilisation aux drogues sont bien moins connus.
Objectif. L'objectif de la présente étude était d'explorer les effets des conditions sociales, à travers la taille des groupes d'hébergement , sur les effets stimulants de l'éthanol et la sensibilisation comportementale induite par l'éthanol chez la souris.
Matériel et méthodes. Des souris Swiss mâles et femelles ont été hébergées en groupes de tailles différentes (souris isolées, deux souris par cage, quatre souris par cage et huit souris par cage) pendant une période de six semaines. Un protocole standard de sensibilisation locomotrice induite par l'éthanol a ensuite été initié au moyen d'une injection quotidienne de 2,5 g/kg d'éthanol pendant 8 jours consécutifs.
Résultats. Les résultats démontrent que les conditions d'hébergement social affectent les effets stimulants aigus de l'éthanol. Les effets stimulants les plus élevés étaient observés chez les souris isolées socialement, puis diminuaient progressivement à mesure de l'augmentation de la taille du groupe. Bien que le taux de sensibilisation à l'éthanol ne différait pas entre les différents groupes, les niveaux de sensibilisation atteints des effets stimulants induits par l'éthanol étaient significativement réduits chez les souris hébergées en groupes de huit.
Conclusions. Ces résultats sont cohérents avec l'idée que des niveaux plus élevés d'effets stimulants aigus et sensibilisés induits par l'éthanol sont observés chez les souris hébergées dans des conditions de logement stressantes, comme l'isolement social.
Van Ingelgom, Théo ; Université de Liège - ULiège > Psychologie et Neuroscience Cognitives (PsyNCog) ; Université de Liège - ULiège > Département de Psychologie > Psychologie quantitative
Didone, Vincent ; Université de Liège - ULiège > Psychologie et Neuroscience Cognitives (PsyNCog) ; Université de Liège - ULiège > Département de Psychologie > Psychologie quantitative
Godefroid, Leeloo ; ULiège - Université de Liège [BE] > Psychologie et Neuroscience Cognitives (PsyNCog) > Département de Psychologie
Quertemont, Etienne ; Université de Liège - ULiège > Département de Psychologie > Psychologie quantitative ; Université de Liège - ULiège > Psychologie et Neuroscience Cognitives (PsyNCog)
Language :
English
Title :
Effects of social housing conditions on ethanol-induced behavioral sensitization in Swiss mice
Alternative titles :
[fr] Effets des conditions d'hébergement social sur la sensibilisation comportementale à l'éthanol chez la souris Swiss
Publication date :
11 January 2024
Journal title :
Psychopharmacology
ISSN :
0033-3158
eISSN :
1432-2072
Publisher :
Springer, Germany
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Effets de la manipulation de l’environnement social sur la vulnérabilité aux effets toxicomanogènes de l’alcool chez la souris
Funders :
ULiège. RISE - Université de Liège. Recherche, Innovation, Support et Entreprises [BE] ULiège FSR - Université de Liège. Fonds spéciaux pour la recherche [BE]
Funding text :
This work was supported by grants from the Recherche, Innovation, Support et Entreprises (RISE) from University
of Liège obtained by Théo van Ingelgom and the Fonds Spéciaux pour la Recherche de l’Université de Liège obtained by Etienne Quertetmont.
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