[en] Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Bousquet, Jean ; Institute of Allergology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. ; University Hospital Montpellier, Montpellier, France. ; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.
Shamji, Mohamed H ; National Heart and Lung Institute (NHLI), Imperial College London, London, UK. ; NIHR Imperial Biomedical Research Centre, London, UK.
Anto, Josep M; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain. ; Universitat Pompeu Fabra (UPF), Barcelona, Spain. ; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Schünemann, Holger J; Department of Health Research Methods, Evidence, and Impact, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Canonica, G Walter; Department of Biomedical Sciences, Humanitas University, Milan, Italy. ; Personalized Medicine, Asthma & Allergy, IRCCS Humanitas Research Center, Milan, Italy.
Jutel, Marek; Department of Clinical Immunology, Wrocław Medical University, Wroclaw, Poland. ; ALL-MED Medical Research Institute, Wroclaw, Poland.
Del Giacco, Stefano ; Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula," University of Cagliari, Cagliari, Italy.
Zuberbier, Torsten ; Institute of Allergology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. ; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.
Pfaar, Oliver ; Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
Fonseca, Joao A; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal. ; CINTESIS@RISE- Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.
Sousa-Pinto, Bernardo; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal. ; CINTESIS@RISE- Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.
Klimek, Ludger ; Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany. ; Center for Rhinology and Allergology, Wiesbaden, Germany.
Czarlewski, Wienczyslawa; Medical Consulting Czarlewski, Levallois, France. ; MASK-air, Montpellier, France.
Bedbrook, Anna; MASK-air, Montpellier, France. ; ARIA, Montpellier, France.
Amaral, Rita ; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal. ; CINTESIS@RISE- Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.
Ansotegui, Ignacio J; Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain.
Bosnic-Anticevich, Sinthia; Quality Use of Respiratory Medicines Group, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia. ; Sydney Local Health District, Sydney, New South Wales, Australia. ; Sydney Pharmacy School, The University of Sydney, Sydney, New South Wales, Australia.
Braido, Fulvio; Respiratory Clinic, Department of Internal Medicine, University of Genoa, Genoa, Italy. ; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Chaves Loureiro, Claudia ; Pneumology Unit, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Gemicioglu, Bilun; Department of Pulmonary Diseases, Istanbul University - Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Istanbul, Turkey.
Haahtela, Tari ; Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Kulus, Marek; Department of Pediatric Respiratory Diseases and Allergology, Medical University of Warsaw, Warsaw, Poland.
Kuna, Piotr; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.
Kupczyk, Maciej; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.
Matricardi, Paolo M ; Pediatric Pulmonology, Immunology and Intensive Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.
Regateiro, Frederico S; Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. ; Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (ICBR), University of Coimbra, Coimbra, Portugal. ; Faculty of Medicine, Institute of Immunology, University of Coimbra, Coimbra, Portugal.
Samolinski, Boleslaw; Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland.
Sofiev, Mikhail; Finnish Meteorological Institute (FMI), Helsinki, Finland.
Toppila-Salmi, Sanna ; Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Valiulis, Arunas; Institute of Clinical Medicine and Institute of Health Sciences, Medical Faculty of Vilnius University, Vilnius, Lithuania.
Ventura, Maria Teresa; Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy. ; Institute of Sciences of Food Production, National Research Council (Ispa-CNR), Bari, Italy.
Barbara, Cristina; Portuguese National Programme for Respiratory Diseases, Direção -Geral da Saúde, Faculdade de Medicina de Lisboa, Instituto de Saúde Ambiental, Lisbon, Portugal.
Bergmann, Karl C; Institute of Allergology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. ; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.
Bewick, Michael; University of Central Lancashire Medical School, Preston, UK.
Blain, Hubert; Department of Geriatrics, Montpellier University Hospital, MUSE, Montpellier, France.
Bonini, Matteo ; National Heart and Lung Institute (NHLI), Imperial College London, London, UK. ; Department of Cardiovascular and Respiratory Sciences, Universita Cattolica del Sacro Cuore, Rome, Italy. ; Department of Neurological, ENT and Thoracic Sciences, Fondazione Policlinico Universitario A Gemelli - IRCCS, Rome, Italy.
Boulet, Louis-Philippe ; Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
Bourret, Rodolphe; University Hospital of Nice, Nice, France.
Brusselle, Guy; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Brussino, Luisa; Department of Medical Sciences, University of Torino, Torino, Italy. ; Allergy and Clinical Immunology Unit, Mauriziano Hospital, Torino, Italy.
Buhl, Roland; Department of Pulmonary Medicine, Mainz University Hospital, Mainz, Germany.
Cardona, Victoria; Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain. ; ARADyAL Research Network, Barcelona, Spain.
Casale, Thomas; Division of Allergy/Immunology, University of South Florida, Tampa, Florida, USA.
Cecchi, Lorenzo ; SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy.
Charpin, Denis; Clinique des Bronches, Allergie et Sommeil, Hôpital Nord, Marseille, France.
Cherrez-Ojeda, Ivan ; Universidad Espíritu Santo, Samborondón, Ecuador. ; Respiralab Research Group, Guayas, Ecuador.
Chu, Derek K; Department of Health Research Methods, Evidence, and Impact, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Cingi, Cemal ; ENT Department, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
Costa, Elisio M; UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing, University of Porto (Porto4Ageing), Porto, Portugal.
Cruz, Alvaro A ; Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Brazil.
Devillier, Philippe; VIM Suresnes, UMR 0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France.
Dramburg, Stephanie; Department of Pediatric Pneumology, Immunology and Intensive Care Medicine, Charité Medical University, Berlin, Germany.
Fokkens, Wytske J ; Department of Otorhinolaryngology, Amsterdam University Medical Centres, Amsterdam, The Netherlands.
Gotua, Maia; Center of Allergy and Immunology, David Tvildiani Medical University, Tbilisi, Georgia.
Heffler, Enrico ; Department of Biomedical Sciences, Humanitas University, Milan, Italy. ; Personalized Medicine, Asthma & Allergy, IRCCS Humanitas Research Center, Milan, Italy.
Ispayeva, Zhanat; Kazakhstan Association of Allergology and Clinical Immunology, Department of Allergology and Clinical Immunology of the Kazakh National Medical University, Almaty, Kazakhstan.
Ivancevich, Juan Carlos; Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina.
Joos, Guy; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Kaidashev, Igor; Poltava State Medical University, Poltava, Ukraine.
Kraxner, Helga; Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary.
Kvedariene, Violeta; Faculty of Medicine, Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Vilnius University, Vilnius, Lithuania. ; Department of Pathology, Faculty of Medicine, Institute of Biomedical Sciences, Vilnius University, Vilnius, Lithuania.
Larenas-Linnemann, Désirée E ; Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.
Laune, Daniel; KYomed INNOV, Montpellier, France.
Lourenço, Olga ; Faculty of Health Sciences and CICS - UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
Louis, Renaud ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Makela, Mika; Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Makris, Michael; Allergy Unit "D Kalogeromitros," 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece.
Maurer, Marcus ; Institute of Allergology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. ; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.
Melén, Erik; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden. ; Sach's Children and Youth Hospital, Stockholm, Sweden.
Micheli, Yann; KYomed INNOV, Montpellier, France.
Morais-Almeida, Mario ; Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.
Mullol, Joaquim; Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Barcelona, Spain. ; Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain.
Niedoszytko, Marek ; Department of Allergology, Medical University of Gdansk, Gdansk, Poland.
O'Hehir, Robyn ; Allergy, Asthma and Clinical Immunology, Alfred Health and Department of Immunology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Olze, Heidi; Department of Otorhinolaryngology, Charité-Universitätsmedizin Berlin, Berlin, Germany. ; Berlin Institute of Health, Berlin, Germany.
Papadopoulos, Nikolaos G ; Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
Papi, Alberto ; Respiratory Medicine, Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
Patella, Vincenzo ; Division of Allergy and Clinical Immunology, Department of Medicine, "Santa Maria della Speranza" Hospital, Battipaglia, Salerno, Italy. ; Agency of Health ASL, Salerno, Italy. ; Postgraduate Programme in Allergy and Clinical Immunology, University of Naples Federico II, Naples, Italy.
Pétré, Benoît ; Université de Liège - ULiège > Département des sciences de la santé publique > Education thérapeutique du patient au service des soins intégrés
Pham-Thi, Nhân; Ecole Polytechnique de Palaiseau, Palaiseau, France. ; IRBA (Institut de Recherche Bio-Médicale des Armées), Brétigny sur Orge, France. ; Université Paris Cité, Paris, France.
Puggioni, Francesca; Personalized Medicine, Asthma & Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.
Quirce, Santiago; Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
Roche, Nicolas; Pneumologie, AP-HP Centre Université de Paris Cité, Hôpital Cochin, et UMR 1016, Institut Cochin, Paris, France.
Rouadi, Philip W ; Department of Otolaryngology, Head and Neck Surgery, Eye and Ear, University Hospital, Beirut, Lebanon. ; Department of Otolaryngology, Head and Neck Surgery, Dar Al Shifa Hospital - Salmiya, Hawally, Kuwait.
Sá-Sousa, Ana; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal. ; CINTESIS@RISE- Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.
Sagara, Hironori; Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, Tokyo, Japan.
Sastre, Joaquin; Allergy Service, Fundacion Jimenez Diaz, Autonoma University of Madrid, CIBERES-ISCIII, Madrid, Spain.
Scichilone, Nicola; PROMISE Department, University of Palermo, Palermo, Italy.
Sheikh, Aziz; Usher Institute, The University of Edinburgh, Edinburgh, UK.
Sova, Milan; Department of Respiratory Medicine and Tuberculosis, University Hospital Brno, Lískovec, Czech Republic.
Suppli Ulrik, Charlotte; Department of Respiratory Medicine, Copenhagen University Hospital-Hvidovre, Copenhagen, Denmark. ; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Taborda-Barata, Luis; Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal. ; UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
Todo-Bom, Ana; Imunoalergologia, Faculty of Medicine, Centro Hospitalar Universitário de Coimbra, University of Coimbra, Coimbra, Portugal.
Torres, Maria J ; Allergy Unit, Málaga Regional University Hospital-IBIMA, Málaga, Spain.
Tsiligianni, Ioanna; International Primary Care Respiratory Group (IPCRG), Aberdeen, UK. ; Health Planning Unit, Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.
Usmani, Omar S; National Heart and Lung Institute (NHLI), Imperial College London, London, UK. ; Royal Brompton Hospital, Airways Disease Section, London, UK.
Valovirta, Erkka; Department of Lung Diseases and Clinical Immunology, University of Turku, Turku, Finland.
Vasankari, Tuula; FIHLA, Finnish Lung Health Association, Helsinki, Finland. ; Department of Clinical Medicine, Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland.
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