[en] In this work, we have prepared novel bio-inspired photoactive antibacterial polymer coatings on stainless steel (SS), which possess good mechanical and antibacterial properties. The formation of the photoactive antibacterial polymer coatings consists of the sequential deposition of three components on SS substrate (1) a catechol-based cationic glue P(mDOPA)-co-P(DMAEMA+) used as a universal primer, which facilitates the strong anchoring to SS; (2) a silver loaded (Pox(mDOPA)-Ag0/PAH) nanogel decorated with o-quinones applied to enhance the antibacterial properties of the coating and to permit the covalent grafting of the photosensitizer, and (3) an ethylene diamine derivative of protoporphyrin IX (PPIX-ED). Porphyrins are widely recognized for their antibacterial activity by producing reactive oxygen species when exposed to visible light. To estimate the deposition of the components on the SS substrate, SEM-EDX elemental mapping analysis was applied. Scratch test, nanoindentation, and accelerated property mapping (XPM) analysis were used to assess the mechanical properties of the coatings. The established antibacterial activity of the prepared photoactive polymer coatings on SS against Gram-positive B. subtilis and Gram-negative E. coli strains demonstrates their potential applications in medical and biomedical fields.
Research center :
CESAM - Complex and Entangled Systems from Atoms to Materials - ULiège [BE] CERM - Center for Education and Research on Macromolecules - ULiège [BE]
Disciplines :
Materials science & engineering Chemistry
Author, co-author :
Bryaskova, Rayna ; University of Chemical Technology and Metallurgy - Sofia - Department of Polymer Engineering - Bulgaria
Philipova, Nikoleta; University of Chemical Technology and Metallurgy - Sofia - Department of Polymer Engineering - Bulgaria
Georgiev, Nikolai; Department of Organic Synthesis, University of Chemical Technology and Metallurgy, Sofia, Bulgaria
Ganchev, Damyan; University of Chemical Technology and Metallurgy - Sofia - Department of Machine Elements and Non-Metal Constructions - Bulgaria
Lalov, Ivo; Department of Biotechnology, University of Chemical Technology and Metallurgy, Sofia, Bulgaria
Detrembleur, Christophe ; University of Chemical Technology and Metallurgy - Sofia - Department of Biotechnology - Bulgaria
Language :
English
Title :
Bio-inspired antibacterial polymer coatings with included silver nanoparticles and porphyrin-based photosensitizer
Publication date :
11 June 2023
Journal title :
Journal of Polymer Research
ISSN :
1022-9760
eISSN :
1572-8935
Publisher :
Springer Science and Business Media B.V.
Volume :
30
Issue :
6
Pages :
1999
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
BNSF - Bulgarian National Science Fund [BG] F.R.S.-FNRS - Fund for Scientific Research [BE] EU - European Union [BE]
Funding text :
This work was supported by the National Science Fund of Bulgaria (project no. KP-06-H29/5). Christophe Detrembleur is Research Director by F.R.S.- FNRS and thanks FNRS for funding. We acknowledge the provided access to the scientific infrastructure of the laboratory of Micro and Nanomechanics of Mechatronic Systems, with financial support by Grant No BG05M2OP001-1.002-0011-C02, financed by the Science and Education for Smart Growth Operational Program (2014–2020) and co-financed by the European Union through the European Structural and Investment funds.
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