Global and regional burden of cancer in 2016 arising from occupational exposure to selected carcinogens: a systematic analysis for the Global Burden of Disease Study 2016.
asbestos; diesel engine exhaust; epidemiology; occupational exposure; silica; Carcinogens; Asbestos; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Asbestos/adverse effects; Disabled Persons/statistics & numerical data; Female; Global Burden of Disease/statistics & numerical data; Global Burden of Disease/trends; Global Health/statistics & numerical data; Global Health/trends; Humans; Lung Neoplasms/mortality; Male; Mesothelioma; Mesothelioma, Malignant; Middle Aged; Neoplasms/epidemiology; Neoplasms/mortality; Occupational Diseases/epidemiology; Occupational Exposure/adverse effects; Occupational Exposure/statistics & numerical data; Quality-Adjusted Life Years; Risk Assessment; Risk Factors; Sex Distribution; Socioeconomic Factors; Young Adult; Life Expectancy; Disabled Persons; Global Burden of Disease; Global Health; Lung Neoplasms; Neoplasms; Occupational Diseases; Public Health, Environmental and Occupational Health
Abstract :
[en] [en] OBJECTIVES: This study provides a detailed analysis of the global and regional burden of cancer due to occupational carcinogens from the Global Burden of Disease 2016 study.
METHODS: The burden of cancer due to 14 International Agency for Research on Cancer Group 1 occupational carcinogens was estimated using the population attributable fraction, based on past population exposure prevalence and relative risks from the literature. The results were used to calculate attributable deaths and disability-adjusted life years (DALYs).
RESULTS: There were an estimated 349 000 (95% Uncertainty Interval 269 000 to 427 000) deaths and 7.2 (5.8 to 8.6) million DALYs in 2016 due to exposure to the included occupational carcinogens-3.9% (3.2% to 4.6%) of all cancer deaths and 3.4% (2.7% to 4.0%) of all cancer DALYs; 79% of deaths were of males and 88% were of people aged 55 -79 years. Lung cancer accounted for 86% of the deaths, mesothelioma for 7.9% and laryngeal cancer for 2.1%. Asbestos was responsible for the largest number of deaths due to occupational carcinogens (63%); other important risk factors were secondhand smoke (14%), silica (14%) and diesel engine exhaust (5%). The highest mortality rates were in high-income regions, largely due to asbestos-related cancers, whereas in other regions cancer deaths from secondhand smoke, silica and diesel engine exhaust were more prominent. From 1990 to 2016, there was a decrease in the rate for deaths (-10%) and DALYs (-15%) due to exposure to occupational carcinogens.
CONCLUSIONS: Work-related carcinogens are responsible for considerable disease burden worldwide. The results provide guidance for prevention and control initiatives.
Disciplines :
Public health, health care sciences & services
Author, co-author :
GBD 2016 Occupational Carcinogens Collaborators
Khosravi, Mohammadhossein ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Language :
English
Title :
Global and regional burden of cancer in 2016 arising from occupational exposure to selected carcinogens: a systematic analysis for the Global Burden of Disease Study 2016.
Deakin University FEDER - Federación Española de Enfermedades Raras FCT - Fundação para a Ciência e a Tecnologia Ministry of Education, Science and Technological Development BMGF - Bill and Melinda Gates Foundation XMUM - Xiamen University Malaysia ISCIII - Carlos III Health Institute Generalitat Valenciana UDCA - University of Applied and Environmental Sciences La Trobe University Public Health Agency of Canada
Funding text :
Acknowledgements BPaQ acknowledges the institutional support of PrOnaBec (national Program of scholarship and educational loan), provided by the Peruvian government; and la Trobe University. aBad acknowledges support from the Public health agency of canada. Fc acknowledges UiD/MUlTi/04378/2019 support with funding from FcT/McTes through national funds. eF acknowledges UiD/ QUi/50006/2019 support with funding from FcT/McTes through national funds. MJak acknowledges that the serbian part of this gBD contribution was cofinanced through grant Oi 175 014 of the Ministry of education science and Technological Development of the republic of serbia. YJK was supported by the Office of research & innovation, Xiamen University Malaysia. WM is currently a Program analyst for Population and Development at the Peru country Office of the United nations Population Fund-UnFPa, an institution which does not necessarily endorse this study. aMs received a fellowship from the egyptian Fulbright Mission Program (eFMP). rsar acknowledges institutional support from applied and environmental sciences University, Bogota, colombia and carlos iii institute of health. sMsi is funded by a senior research Fellowship from the institute for Physical activity and nutrition (iPan), Deakin University. rT-s was supported in part by grant number PrOMeTeOii/2015/021 from generalitat Valenciana and the national grant Pi17/00719 from isciii-FeDerFunding The overall gBD study is partly funded by the Bill & Melinda gates Foundation. The work reported in this paper was partly supported by funding from the World health Organization. The funders had no role in the study design, data collection, data analysis, data interpretation or writing of the report. The authors had access to the data in the study and the final responsibility to submit the paper.
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