Therapeutic effects of Rosa canina, Urtica dioica and Tanacetum vulgare herbal combination in treatment of tinnitus symptoms: A double-blind randomised clinical trial.
Rosa canina; Tanacetum vulgare; Tinnitus Handicap Inventory; Tinnitus and Neurotec; Urtica dioica; subjective tinnitus; Male; Female; Humans; Adult; Middle Aged; Aged; Audiometry, Pure-Tone; Visual Analog Scale; Tinnitus/diagnosis; Rosa; Tinnitus; Otorhinolaryngology
Abstract :
[en] [en] OBJECTIVE: To evaluate the effect of Neurotec® herbal capsule (100 mg twice a day for 3 months) on the tinnitus symptoms in comparison with the placebo.
DESIGN: A double-blind randomised clinical trial.
SETTING: Otolaryngology clinic of Baqiyatallah Hospital.
PARTICIPANTS: Patients suffering from subjective tinnitus.
MAIN OUTCOME MEASURES: Pure tone audiometry was measured at .5, 1, 2, 4 and 6 kHz frequencies before and after the third month of intervention. In addition, Tinnitus Handicap Inventory (THI) questionnaire as well as visual analogue scale (VAS) for tinnitus loudness, daily annoyance, daily life or sleep disturbance, daily perception and mood alteration were evaluated.
RESULTS: Finally, 103 (69 males and 34 females) patients with a mean age of 51.33 ± 13.91 years were analysed. In contrast with control group, patients in intervention group showed a remarkable decrease in THI score after 3 months of treatment (p < .05). Although both groups had improvements in VAS scores, mood disturbance, daily tinnitus perception and daily life alteration scores were only improved in the intervention group. The mean pure tone air and bone conduction were not significantly different between the control and the intervention group at baseline and 3 months after the intervention at .5, 1, 2 and 4 kHz (p > .05).
CONCLUSION: A 3-month treatment with Neurotec capsules in addition to patient education is of benefit for managing symptoms in patients with chronic tinnitus.
Disciplines :
Otolaryngology
Author, co-author :
Khosravi, Mohammadhossein ; Université de Liège - ULiège > GIGA ; Department of Research, Arka Education and Clinical Research Consultants, Tehran, Iran
Atefi, Amirhomayoun ; Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Mehri, Afsaneh ; Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Sodeifian, Fatemeh ; Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran
Yousefi, Jaleh ; Department of Otorhinolaryngology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
Bagheri Hagh, Ali ; Department of Otorhinolaryngology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
Sohrabpour, Saeed ; Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Kazemi, Fatemeh ; Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran
Ajalloueian, Mohammad ; New Hearing Technologies Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Saeedi, Masoumeh ; New Hearing Technologies Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Language :
English
Title :
Therapeutic effects of Rosa canina, Urtica dioica and Tanacetum vulgare herbal combination in treatment of tinnitus symptoms: A double-blind randomised clinical trial.
We would like to thank the Baqiyatallah otolaryngology clinic secretary, Mr. Abbaspour, for his nice cooperation upon the management of visit sessions. In addition, we appreciate the efforts of the audiology team at Baqiyatallah otolaryngology clinic for this project.
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