[en] [en] INTRODUCTION: Brain hypometabolism patterns have been previously associated with cognitive decline in Parkinson's disease (PD). Our aim is to evaluate the impact of single-subject fluorodeoxyglucose (FDG)-PET brain hypometabolism on long-term cognitive and motor outcomes in PD.
METHODS: Forty-nine non-demented PD patients with baseline brain FDG-PET data underwent an extensive clinical follow-up for 8 years. The ability of FDG-PET to predict long-term cognitive and motor progression was evaluated using Cox regression and mixed ANCOVA models.
RESULTS: Participants were classified according to FDG-PET pattern in PD with typical (n = 26) and atypical cortical metabolism (n = 23). Patients with atypical brain hypometabolic patterns showed higher incidence of dementia (60% vs 3%; HR = 18.3), hallucinations (56% vs 7%, HR = 7.3) and faster motor decline compared to typical pattern group.
CONCLUSION: This study argues for specific patterns of FDG-PET cortical hypometabolism in PD as a prognostic marker for long term cognitive and motor outcomes at single-subject level.
Disciplines :
Neurology
Author, co-author :
Imarisio, Alberto ; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
Pilotto, Andrea ; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy, Neurology Unit, Department of Continuity of Care and Frailty, ASST Spedali Civili Brescia University Hospital, Italy, Laboratory of Digital Neurology and Biosensors, University of Brescia, Italy. Electronic address: andrea.pilotto@unibs.it
Premi, Enrico; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy, Stroke Unit, Department of Neurological and Vision Sciences, ASST Spedali Civili, Brescia, Italy
Caminiti, Silvia Paola; In Vivo Human Molecular and Structural Neuroimaging Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy
Presotto, Luca ; Department of Physics "G. Occhialini", University of Milano - Bicocca, Milan, Italy, Milan Centre for Neuroscience, University of Milano - Bicocca, Milan, Italy
Sala, Arianna ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; In Vivo Human Molecular and Structural Neuroimaging Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy
Zatti, Cinzia; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy, Neurology Unit, Department of Continuity of Care and Frailty, ASST Spedali Civili Brescia University Hospital, Italy, Laboratory of Digital Neurology and Biosensors, University of Brescia, Italy
Lupini, Alessandro; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy, Neurology Unit, Department of Continuity of Care and Frailty, ASST Spedali Civili Brescia University Hospital, Italy, Laboratory of Digital Neurology and Biosensors, University of Brescia, Italy
Turrone, Rosanna; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy, Neurology Unit, Department of Continuity of Care and Frailty, ASST Spedali Civili Brescia University Hospital, Italy
Paghera, Barbara; Nuclear Medicine Unit, University of Brescia, Brescia, Italy
Borroni, Barbara; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
Perani, Daniela; In Vivo Human Molecular and Structural Neuroimaging Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy, Nuclear Medicine Unit, San Raffaele Hospital, Milan, Italy
Padovani, Alessandro ; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy, Neurology Unit, Department of Continuity of Care and Frailty, ASST Spedali Civili Brescia University Hospital, Italy, Laboratory of Digital Neurology and Biosensors, University of Brescia, Italy
Daniela Perani is funded by a Grant of Fondazione CARIPLO , Bando Ricerca 2014 Malattie Invecchiamento, Project Title “Evaluation of autonomic, genetic, imaging and biochemical markers for Parkinson-related dementia, 2015–2017 and the EU FP7 INMIND Project (FP7-HEALTH-2013 , grant agreement no. 278850 ).Andrea Pilotto received speaker honoraria from Biomarin, Roche, Zambon, Nutricia and Chiesi pharmaceuticals. He is supported by the grant IMI H2020 initiative ( MI2-2018-15-06 ) and a Grant of Ministry of University (MURST) , Airalzh Fundation and the Segala Grant from LIMPE-DISMOV Society .This study was approved by local Ethic Committee and complies with the Helsinki Declaration (grant number NP 1471, DMA). Written informed consent was obtained from all participants.Andrea Pilotto received speaker honoraria from Biomarin, Roche, Zambon, Nutricia and Chiesi pharmaceuticals. He is supported by the grant IMI H2020 initiative (MI2-2018-15-06) and a Grant of Ministry of University (MURST), Airalzh Fundation and the Segala Grant from LIMPE-DISMOV Society.Daniela Perani is funded by a Grant of Fondazione CARIPLO, Bando Ricerca 2014 Malattie Invecchiamento, Project Title “Evaluation of autonomic, genetic, imaging and biochemical markers for Parkinson-related dementia, 2015–2017 and the EU FP7 INMIND Project (FP7-HEALTH-2013, grant agreement no. 278850).
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