DWI; fMRI; functional connectivity; molecular connectivity; multimodal imaging; Neurology; Neurology (clinical); Cardiology and Cardiovascular Medicine
Abstract :
[en] Functional magnetic resonance and diffusion weighted imaging have so far made a major contribution to delineation of the brain connectome at the macroscale. While functional connectivity (FC) was shown to be related to structural connectivity (SC) to a certain degree, their spatial overlap is unknown. Even less clear are relations of SC with estimates of connectivity from inter-subject covariance of regional F18-fluorodeoxyglucose uptake (FDGcov) and grey matter volume (GMVcov). Here, we asked to what extent SC underlies three proxy estimates of brain connectivity: FC, FDGcov and GMVcov. Simultaneous PET/MR acquisitions were performed in 56 healthy middle-aged individuals. Similarity between four networks was assessed using Spearman correlation and convergence ratio (CR), a measure of spatial overlap. Spearman correlation coefficient was 0.27 for SC-FC, 0.40 for SC-FDGcov, and 0.15 for SC-GMVcov. Mean CRs were 51% for SC-FC, 48% for SC-FDGcov, and 37% for SC-GMVcov. These results proved to be reproducible and robust against image processing steps. In sum, we found a relevant similarity of SC with FC and FDGcov, while GMVcov consistently showed the weakest similarity. These findings indicate that white matter tracts underlie FDGcov to a similar degree as FC, supporting FDGcov as estimate of functional brain connectivity.
Disciplines :
Neurosciences & behavior
Author, co-author :
Lizarraga, Aldana; Department of Nuclear Medicine, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany
Ripp, Isabelle ; Department of Nuclear Medicine, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany
Sala, Arianna ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; Department of Nuclear Medicine, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany
Shi, Kuangyu; Department of Nuclear Medicine, University Hospital Bern, Bern, Switzerland
Düring, Marco; Medical Image Analysis Center (MIAC AG) and Qbig, Department of Biomedical Engineering, University of Basel, Basel, Switzerland
Koch, Kathrin; Department of Neuroradiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany
Yakushev, Igor; Department of Nuclear Medicine, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany
Language :
English
Title :
Similarity between structural and proxy estimates of brain connectivity.
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the German Research Foundation (DFG), grants to I.Y. (grant number YA 373/3-1) and to K.K. (grant number KO 3744/8-1), and by the Federal Ministry of Education and Research Germany (BMBF), grant to I.Y. (grant number 031L0200B). Acknowledgements
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