Article (Scientific journals)
European multidisciplinary tumor boards support cross-border networking and increase treatment options for patients with rare gynecological tumors.
Joneborg, Ulrika; Bergamini, Alice; Wallin, Emelie et al.
2023In International Journal of Gynecological Cancer, 33 (10), p. 1621 - 1626
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Keywords :
Gestational Trophoblastic Disease; Ovarian Neoplasms; Sex Cord-Gonadal Stromal Tumors; Trophoblastic Neoplasms; Female; Humans; Off-Label Use; Health Personnel; Europe; Genital Neoplasms, Female/diagnosis; Genital Neoplasms, Female/therapy; Genital Neoplasms, Female; Oncology; Obstetrics and Gynecology
Abstract :
[en] [en] OBJECTIVE: To evaluate outcomes of European cross-border multidisciplinary tumor boards in terms of participation, adherence to treatment recommendations, and access to novel treatment strategies. METHODS: The European reference network for rare gynecological tumors (EURACAN G2 domain) aims to improve the diagnosis, management, and treatment of patients with these cancers. Cross-border multidisciplinary tumor boards were initiated to facilitate intercollegiate clinical discussions across Europe and increase patients' access to specialist treatment recommendations and clinical trials. All G2 healthcare providers were invited to participate in monthly multidisciplinary meetings. Patient data were collected using a standardized form and case summaries were distributed before each meeting. After each tumor board, a meeting summary with treatment recommendations was sent to all participants and the project manager at the coordinating center. The multidisciplinary tumor board format and outcomes were regularly discussed at G2 domain meetings. Anonymized clinical data and treatment recommendations were registered in a prospective database. For this report, clinical data were collected between November 2017 and December 2020 and follow-up data retrieved until May 2021. RESULTS: During the 3-year period, 31 multidisciplinary tumor boards were held with participants from 10 countries and 20 centers. 91 individual patients were discussed between one and six times for a total of 109 case discussions. Follow-up data were retrieved from 64 patients and 80 case discussions. Adherence to treatment recommendations was 99%. Multidisciplinary tumor board recommendations resulted in 11 patients getting access to off-label treatment and one patient being enrolled in a clinical trial in another European country. 14/91 patients were recommended for surveillance only when additional treatment had been considered locally. CONCLUSION: Cross-border multidisciplinary tumor boards enable networking and clinical collaboration between healthcare professionals in different countries. Surveillance strategies, off-label drug use, and increased participation in clinical trials are possible benefits to patients with rare gynecological tumors.
Disciplines :
Oncology
Author, co-author :
Joneborg, Ulrika ;  Department of Pelvic Cancer, Karolinska University Hospital, Stockholm, Sweden ulrika.joneborg@regionstockholm.se ; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
Bergamini, Alice;  San Raffaele Hospital Department of Obstetrics and Gynaecology, Milano, Italy ; Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milano, Italy
Wallin, Emelie;  Department of Pelvic Cancer, Karolinska University Hospital, Stockholm, Sweden ; Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
Mangili, Giorgia;  San Raffaele Hospital Department of Obstetrics and Gynaecology, Milano, Italy
Solheim, Olesya ;  Department of Gynecological Oncology, Oslo University Hospital, Oslo, Norway
Marquina, Gloria ;  Department of Medical Oncology, Hospital Clinico San Carlos, Madrid, Spain ; Department of Medicine, Complutense University of Madrid, Madrid, Spain
Casado, Antonio;  Department of Medicine, Complutense University of Madrid, Madrid, Spain ; Department of Medical Oncology, Hospital Clínico San Carlos, Madrid, Spain
Rokkones, Erik;  Department of Gynecological Oncology, Oslo University Hospital, Oslo, Norway
Coulter, John;  Department of Gynaecological Oncology, Cork University Hospital, Cork, Ireland
Lok, Christianne A R ;  Department of Gynecologic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
van Trommel, Nienke;  Department of Gynecologic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
Amant, Frédéric ;  Division of Gynecologic Oncology, KU Leuven University Hospitals Leuven, Leuven, Belgium ; Division of Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands
Bolze, Pierre-Adrien;  Hospices Civils de Lyon, Universite Lyon 1 Faculte de Medecine et de Maieutique Lyon-Sud Charles Merieux, Lyon, France ; Department of Gynecological and Oncological Surgery and Obstetrics, Hospital Lyon-South, Lyon, France
Sehouli, Jalid ;  Department of Gynecology with Center of Oncological Surgery, Charite Medical Faculty Berlin, Berlin, Germany
Han, Sileny ;  Division of Gynecologic Oncology, KU Leuven University Hospitals Leuven, Leuven, Belgium
Kridelka, Frédéric ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gynécologie-obstétrique
Goffin, Frédéric ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gynécologie-obstétrique (CHR)
Pautier, Patricia;  Gustave Roussy Institute, Villejuif, France ; Paris-Saclay University, Villejuif, France
Ray-Coquard, Isabelle ;  Centre Leon Berard, Lyon, France ; Université Claude Bernard Lyon 1, Villeurbanne, France
Seckl, Michael ;  Department of Medical Oncology, Imperial College London - Charing Cross Campus, London, UK
More authors (10 more) Less
Language :
English
Title :
European multidisciplinary tumor boards support cross-border networking and increase treatment options for patients with rare gynecological tumors.
Publication date :
02 October 2023
Journal title :
International Journal of Gynecological Cancer
ISSN :
1048-891X
eISSN :
1525-1438
Publisher :
BMJ Publishing Group, England
Volume :
33
Issue :
10
Pages :
1621 - 1626
Peer reviewed :
Peer Reviewed verified by ORBi
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