Dogs; Animals; Tomography, X-Ray Computed/veterinary; Tomography, X-Ray Computed/methods; Blood Volume/physiology; Carcinoma, Squamous Cell/diagnostic imaging; Carcinoma, Squamous Cell/veterinary; Carcinoma, Squamous Cell/blood supply; Sarcoma/diagnostic imaging; Sarcoma/veterinary; Dog Diseases/diagnostic imaging; Blood Volume; Carcinoma, Squamous Cell; Dog Diseases; Sarcoma; Tomography, X-Ray Computed; Veterinary (all); General Veterinary; General Medicine
Abstract :
[en] [en] OBJECTIVE: Treatment of orofacial tumors in dogs is associated with high morbidity and reliable prognostic factors are lacking. Dynamic contrast-enhanced computed tomography (DCECT) can be used to assess tumor perfusion. The objectives of this study were to describe the perfusion parameters of different types of orofacial tumors and to describe the changes in perfusion parameters during radiotherapy (RT) in a subset of them.
ANIMALS: 11 dogs with orofacial tumors prospectively recruited.
CLINICAL PRESENTATION AND PROCEDURES: All dogs had baseline DCECT to assess blood volume (BV), blood flow (BF), and transit time (TT). Five dogs had repeat DCECT during megavoltage RT.
RESULTS: 5 squamous cell carcinomas, 3 sarcomas, 1 melanoma, 1 histiocytic sarcoma, and 1 acanthomatous ameloblastoma were included. Blood volume and BF were higher in squamous cell carcinomas than in sarcomas, although no statistical analysis was performed. At repeat DCECT, 4 dogs showed a reduction in the size of their tumor during RT. Among these dogs, 3 showed an increase in BV and BF and 1 a decrease in these parameters between the baseline and the follow-up DCECT. The only dog whose tumor increased in size between the first and the second DCECT showed a decrease in BV and BF.
CLINICAL RELEVANCE: Perfusion parameters derived from DCECT were described in a series of dogs with various types of orofacial tumors. The results suggest that epithelial tumors could have higher BV and BF than mesenchymal tumors, although larger sample sizes are needed to support these preliminary findings.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Mortier, Jérémy ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) ; Small Animal Teaching Hospital, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston, United Kingdom
Maddox, Thomas W; Small Animal Teaching Hospital, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston, United Kingdom
Blackwood, Laura; Small Animal Teaching Hospital, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston, United Kingdom
La Fontaine, Matthew D; The Netherlands Cancer Institute, Amsterdam, the Netherlands
Busoni, Valeria ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Médecine vétérinaire comparée
Language :
English
Title :
Dynamic contrast-enhanced computed tomography in 11 dogs with orofacial tumors.
Publication date :
01 May 2023
Journal title :
American Journal of Veterinary Research
ISSN :
0002-9645
eISSN :
1943-5681
Publisher :
American Veterinary Medical Association, United States
Results from this study were presented at the EAVDI-BID meeting 2022 in Warwick, UK. The authors received a research grant from the university of Liège for this work.
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