Article (Scientific journals)
Effect of cognitive reserve on the association between slow wave sleep and cognition in community-dwelling older adults.
Ourry, Valentin; Rehel, Stéphane; André, Claire et al.
2023In Aging, 15 (18), p. 9275 - 9292
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Keywords :
aging; cognition; cognitive reserve; sleep; Aged; Humans; Cognition; Independent Living; Neuropsychological Tests; Sleep; Cognitive Reserve; Sleep, Slow-Wave; Cell Biology
Abstract :
[en] Sleep, especially slow wave sleep (SWS), is essential for cognitive functioning and is reduced in aging. The impact of sleep quality on cognition is variable, especially in aging. Cognitive reserve (CR) may be an important modulator of these effects. We aimed at investigating this question to better identify individuals in whom sleep disturbances might have greater behavioral consequences. Polysomnography and neuropsychological assessments were performed in 135 cognitively intact older adults (mean age ± SD: 69.4 ± 3.8y) from the Age-Well randomized controlled trial (baseline data). Two measures of cognitive engagement throughout life were used as CR proxies. Linear regression analyses were performed between the proportion of SWS, and executive function and episodic memory composite scores. Then, interaction analyses between SWS and CR proxies on cognition were conducted to assess the possible impact of CR on these links. SWS was positively associated with episodic memory, but not with executive function. CR proxies modulated the associations between SWS and both executive and episodic memory performance. Specifically, individuals with higher CR were able to maintain cognitive performance despite low amounts of SWS. This study provides the first evidence that CR may protect against the deleterious effects of age-related sleep changes on cognition.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège [BE]
Disciplines :
Neurosciences & behavior
Author, co-author :
Ourry, Valentin;  Normandie University, UNICAEN, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institut Blood and Brain @ Caen-Normandie, Cyceron, France ; Normandie University, UNICAEN, PSL Université,, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, NIMH, Caen, France
Rehel, Stéphane;  Normandie University, UNICAEN, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institut Blood and Brain @ Caen-Normandie, Cyceron, France ; Normandie University, UNICAEN, PSL Université,, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, NIMH, Caen, France
André, Claire;  Normandie University, UNICAEN, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institut Blood and Brain @ Caen-Normandie, Cyceron, France ; Normandie University, UNICAEN, PSL Université,, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, NIMH, Caen, France
Mary, Alison;  Neuropsychology and Functional Imaging Research Group (UR2NF), Centre for Research in Cognition and Neurosciences (CRCN), UNI - ULB Neuroscience Institute, Bruxelles 1050, Belgium
Paly, Léo;  Normandie University, UNICAEN, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institut Blood and Brain @ Caen-Normandie, Cyceron, France
Delarue, Marion;  Normandie University, UNICAEN, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institut Blood and Brain @ Caen-Normandie, Cyceron, France
Requier, Florence  ;  Université de Liège - ULiège > Département de Psychologie > Neuropsychologie de l'adulte ; ULiège - Université de Liège [BE] > GIGA > GIGA CRC In vivo imaging
Hendy, Anne;  Division of Psychiatry, University College London, London, United Kingdom
Collette, Fabienne  ;  Université de Liège - ULiège > Département de Psychologie ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging
Marchant, Natalie L;  Division of Psychiatry, University College London, London, United Kingdom
Felisatti, Francesca;  Normandie University, UNICAEN, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institut Blood and Brain @ Caen-Normandie, Cyceron, France
Palix, Cassandre;  Normandie University, UNICAEN, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institut Blood and Brain @ Caen-Normandie, Cyceron, France
Vivien, Denis;  Normandie University, UNICAEN, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institut Blood and Brain @ Caen-Normandie, Cyceron, France ; Dé,partement de Recherche Clinique, CHU de Caen, Caen, France
de la Sayette, Vincent;  Normandie University, UNICAEN, PSL Université,, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, NIMH, Caen, France ; Service de Neurologie, CHU de Caen, Caen, France
Chételat, Gaël;  Normandie University, UNICAEN, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institut Blood and Brain @ Caen-Normandie, Cyceron, France
Gonneaud, Julie;  Normandie University, UNICAEN, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institut Blood and Brain @ Caen-Normandie, Cyceron, France
Rauchs, Géraldine ;  Université de Liège - ULiège > Unités de recherche interfacultaires > GIGA-CRC In vivo Imaging (Centre de Recherche du Cyclotron) ; Normandie University, UNICAEN, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institut Blood and Brain @ Caen-Normandie, Cyceron, France
Medit-Ageing Research Group
More authors (8 more) Less
Language :
English
Title :
Effect of cognitive reserve on the association between slow wave sleep and cognition in community-dwelling older adults.
Publication date :
28 September 2023
Journal title :
Aging
eISSN :
1945-4589
Publisher :
Impact Journals LLC, United States
Volume :
15
Issue :
18
Pages :
9275 - 9292
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
H2020 - 667696 - MEDIT-AGEING - Investigating the impact of meditation training on mental health and wellbeing in the ageing population
Funders :
Union Européenne [BE]
Funding text :
The Age-Well randomized clinical trial is part of the Medit-Ageing project and this work was supported by the European Union’s Horizon 2020 Research and Innovation Program (grant agreement No: 667696), Institut National de la Santé et de la Recherche Médicale (INSERM), Région Normandie, Association France Alzheimer (AAPSM2017, grant 1714), Fondation Alzheimer, Fondation Recherche Alzheimer, Fondation d’Entreprise MMA des Entrepreneurs du Futur and Fondation Entrepreneurs MMA. Complementary funding sources were obtained from the Fondation Ligue Européenne Contre la Maladie d’Alzheimer– Vaincre Alzheimer (grant 13732) and the Fondation Thérèse et René Planiol. The funders and sponsor had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Valentin Ourry was funded by a PhD grant from Association France Alzheimer (AAPSM 2017, grant 1714), Région Normandie and the Fonds Européen de Développement Régional (FEDER). Julie Gonneaud received funding from the Fondation Alzheimer and Fondation de France (Allocation Jeune Chercheur). Fabienne Collette is supported by the F.R.S.-FNRS-Belgium.
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