Effects of a mindfulness-based intervention and a health self-management programme on psychological well-being in older adults with subjective cognitive decline: Secondary analyses from the SCD-Well randomised clinical trial.
[en] [en] OBJECTIVES: Older adults with subjective cognitive decline (SCD) recruited from memory clinics have an increased risk of developing dementia and regularly experience reduced psychological well-being related to memory concerns and fear of dementia. Research on improving well-being in SCD is limited and lacks non-pharmacological approaches. We investigated whether mindfulness-based and health education interventions can enhance well-being in SCD.
METHODS: The SCD-Well trial (ClinicalTrials.gov: NCT03005652) randomised 147 older adults with SCD to an 8-week caring mindfulness-based approach for seniors (CMBAS) or an active comparator (health self-management programme [HSMP]). Well-being was assessed at baseline, post-intervention, and 6-month post-randomisation using the Psychological Well-being Scale (PWBS), the World Health Organisation's Quality of Life (QoL) Assessment psychological subscale, and composites capturing meditation-based well-being dimensions of awareness, connection, and insight. Mixed effects models were used to assess between- and within-group differences in change.
RESULTS: CMBAS was superior to HSMP on changes in connection at post-intervention. Within both groups, PWBS total scores, psychological QoL, and composite scores did not increase. Exploratory analyses indicated increases in PWBS autonomy at post-intervention in both groups.
CONCLUSION: Two non-pharmacological interventions were associated with only limited effects on psychological well-being in SCD. Longer intervention studies with waitlist/retest control groups are needed to assess if our findings reflect intervention brevity and/or minimal base rate changes in well-being.
Research Center/Unit :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Schlosser, Marco ; Department of Psychology, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland ; Division of Psychiatry, Faculty of Brain Sciences, University College London, London, United Kingdom
Demnitz-King, Harriet ; Division of Psychiatry, Faculty of Brain Sciences, University College London, London, United Kingdom
Barnhofer, Thorsten; School of Psychology, University of Surrey, Surrey, United Kingdom
Collette, Fabienne ; Université de Liège - ULiège > Département de Psychologie ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Gonneaud, Julie; Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", Institut Blood and Brain @ Caen-Normandie, Cyceron, Caen, France
Chételat, Gaël; Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", Institut Blood and Brain @ Caen-Normandie, Cyceron, Caen, France
Jessen, Frank; Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany ; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany ; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany
Kliegel, Matthias; Department of Psychology, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland
Klimecki, Olga ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie de l'adulte ; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland ; Clinical Psychology and Behavioral Neuroscience, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany
Lutz, Antoine ; Eduwell team, Lyon Neuroscience Research Center Inserm U1028, CNRS UMR5292, Lyon 1 University, Lyon, France
Marchant, Natalie L ; Division of Psychiatry, Faculty of Brain Sciences, University College London, London, United Kingdom
Medit-Ageing Research Group
Language :
English
Title :
Effects of a mindfulness-based intervention and a health self-management programme on psychological well-being in older adults with subjective cognitive decline: Secondary analyses from the SCD-Well randomised clinical trial.
Jessen F, Amariglio RE, Buckley RF, van der Flier WM, Han Y, Molinuevo JL, et al. The characterisation of subjective cognitive decline. Lancet Neurol. 2020 Mar; 19(3):271–8. https://doi.org/10.1016/S1474-4422(19)30368-0 PMID: 31958406
Mitchell AJ, Beaumont H, Ferguson D, Yadegarfar M, Stubbs B. Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis. Acta Psychiatr Scand. 2014 Dec; 130(6):439–51. https://doi.org/10.1111/acps.12336 PMID: 25219393
Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet Lond Engl. 2020; 396 (10248):413–46. https://doi.org/10.1016/S0140-6736(20)30367-6 PMID: 32738937
Metternich B, Kosch D, Kriston L, Härter M, Hüll M. The Effects of Nonpharmacological Interventions on Subjective Memory Complaints: A Systematic Review and Meta-Analysis. Psychother Psychosom. 2010; 79(1):6–19. https://doi.org/10.1159/000254901 PMID: 19887887
Molinuevo JL, Rabin LA, Amariglio R, Buckley R, Dubois B, Ellis KA, et al. Implementation of subjective cognitive decline criteria in research studies. Alzheimers Dement. 2017; 13(3):296–311. https://doi.org/10.1016/j.jalz.2016.09.012 PMID: 27825022
Bhome R, Berry AJ, Huntley JD, Howard RJ. Interventions for subjective cognitive decline: systematic review and meta-analysis. BMJ Open. 2018 Jul; 8(7):e021610. https://doi.org/10.1136/bmjopen-2018-021610 PMID: 30030318
Dahl CJ, Wilson-Mendenhall CD, Davidson RJ. The plasticity of well-being: A training-based framework for the cultivation of human flourishing. Proc Natl Acad Sci. 2020 Dec 22; 117(51):32197–206. https://doi.org/10.1073/pnas.2014859117 PMID: 33288719
Gu J, Strauss C, Bond R, Cavanagh K. How do mindfulness-based cognitive therapy and mindfulness-based stress reduction improve mental health and wellbeing? A systematic review and meta-analysis of mediation studies. Clin Psychol Rev. 2015 Apr 1; 37:1–12. https://doi.org/10.1016/j.cpr.2015.01.006 PMID: 25689576
Marchant NL, Barnhofer T, Coueron R, Wirth M, Lutz A, Arenaza-Urquijo EM, et al. Effects of a Mindfulness-Based Intervention versus Health Self-Management on Subclinical Anxiety in Older Adults with Subjective Cognitive Decline: The SCD-Well Randomized Superiority Trial. Psychother Psychosom. 2021 Apr 19;1–10. https://doi.org/10.1159/000515669 PMID: 33873195
Smart CM, Segalowitz SJ, Mulligan BP, Koudys J, Gawryluk JR. Mindfulness Training for Older Adults with Subjective Cognitive Decline: Results from a Pilot Randomized Controlled Trial. J Alzheimers Dis. 2016 Jan 1; 52(2):757–74. https://doi.org/10.3233/JAD-150992 PMID: 27060951
Ryff CD. Psychological Well-Being Revisited: Advances in the Science and Practice of Eudaimonia. Psychother Psychosom. 2014; 83(1):10–28. https://doi.org/10.1159/000353263 PMID: 24281296
Ryff CD. Happiness is everything, or is it? Explorations on the meaning of psychological well-being. J Pers Soc Psychol. 1989; 57(6):1069–81.
The Whoqol Group. Development of the World Health Organization WHOQOL-BREF Quality of Life Assessment. Psychol Med. 1998 May; 28(3):551–8.
Ryff CD, Lee C, Keyes M. The structure of psychological well-being revisited. In: Journal of Personality & Social Psychology. 1995. p. 719–27. https://doi.org/10.1037//0022-3514.69.4.719 PMID: 7473027
Schlosser M, Barnhofer T, Requier F, Deza-Araujo YI, Abdoun O, Marchant NL, et al. Measuring Psychological Mechanisms in Meditation Practice: Using a Phenomenologically Grounded Classification System to Develop Theory-Based Composite Scores. Mindfulness. 2022 Mar 1; 13(3):600–14.
Dahl CJ, Lutz A, Davidson RJ. Reconstructing and deconstructing the self: cognitive mechanisms in meditation practice. Trends Cogn Sci. 2015 Sep 1; 19(9):515–23. https://doi.org/10.1016/j.tics.2015.07. 001 PMID: 26231761
Lutz A, Chételat G, Collette F, Klimecki OM, Marchant NL, Gonneaud J. The protective effect of mindfulness and compassion meditation practices on ageing: Hypotheses, models and experimental implementation. Ageing Res Rev. 2021 Dec 1; 72:101495. https://doi.org/10.1016/j.arr.2021.101495 PMID: 34718153
Marchant NL, Barnhofer T, Klimecki OM, Poisnel G, Lutz A, Arenaza-Urquijo E, et al. The SCD-Well randomized controlled trial: Effects of a mindfulness-based intervention versus health education on mental health in patients with subjective cognitive decline (SCD). Alzheimers Dement Transl Res Clin Interv. 2018; 4(1):737–45. https://doi.org/10.1016/j.trci.2018.10.010 PMID: 30581979
Jessen F, Amariglio RE, Boxtel M van, Breteler M, Ceccaldi M, Chételat G, et al. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease. Alzheimers Dement. 2014; 10(6):844–52. https://doi.org/10.1016/j.jalz.2014.01.001 PMID: 24798886
Lorig K, Holman H, Sobel D, Laurent D, Gonzalez V, Minor M. Living a Healthy Life with Chronic Conditions: For Ongoing Physical and Mental Health Conditions. 4th ed. Bull Publishing Company; 2012.
Mehling WE, Price C, Daubenmier JJ, Acree M, Bartmess E, Stewart A. The Multidimensional Assessment of Interoceptive Awareness (MAIA). PLOS ONE. 2012 Nov 1; 7(11):e48230. https://doi.org/10.1371/journal.pone.0048230 PMID: 23133619
Baer RA, Smith GT, Hopkins J, Krietemeyer J, Toney L. Using Self-Report Assessment Methods to Explore Facets of Mindfulness. Assessment. 2006 Mar 1; 13(1):27–45. https://doi.org/10.1177/ 1073191105283504 PMID: 16443717
Sprecher S, Fehr B. Compassionate love for close others and humanity. J Soc Pers Relatsh. 2005 Oct 1; 22(5):629–51.
Schlosser M, Pfaff NG, Schweinberger SR, Marchant NL, Klimecki OM. The psychometric properties of the compassionate love scale and the validation of the English and German 7-item compassion for others scale (COS-7). Curr Psychol. 2021; 42(1):579–91.
Forman EM, Herbert JD, Juarascio AS, Yeomans PD, Zebell JA, Goetter EM, et al. The Drexel defusion scale: A new measure of experiential distancing. J Context Behav Sci. 2012 Dec 10; 1(1):55–65.
Chen KW, Berger CC, Manheimer E, Forde D, Magidson J, Dachman L, et al. Meditative therapies for reducing anxiety: a systematic review and meta-analysis of randomized controlled trials. Depress Anxiety. 2012 Jul; 29(7):545–62. https://doi.org/10.1002/da.21964 PMID: 22700446
John OP, Srivastava S. The Big Five Trait taxonomy: History, measurement, and theoretical perspectives. In: Handbook of personality: Theory and research, 2nd ed. New York, NY, US: Guilford Press; 1999. p. 102–38.
Chételat G, Lutz A, Arenaza-Urquijo E, Collette F, Klimecki O, Marchant N. Why could meditation practice help promote mental health and well-being in aging? Alzheimers Res Ther. 2018 Jun 22; 10(1):57. https://doi.org/10.1186/s13195-018-0388-5 PMID: 29933746
Goldberg SB, Imhoff-Smith T, Bolt DM, Wilson-Mendenhall CD, Dahl CJ, Davidson RJ, et al. Testing the Efficacy of a Multicomponent, Self-Guided, Smartphone-Based Meditation App: Three-Armed Randomized Controlled Trial. JMIR Ment Health. 2020 Nov 27; 7(11):e23825. https://doi.org/10.2196/ 23825 PMID: 33245288
Hirshberg MJ, Frye C, Dahl CJ, Riordan KM, Vack NJ, Sachs J, et al. A randomized controlled trial of a smartphone-based well-being training in public school system employees during the COVID-19 pandemic. J Educ Psychol. 2022;No Pagination Specified-No Pagination Specified. https://doi.org/10.1037/ edu0000739 PMID: 36387982
Poisnel G, Arenaza-Urquijo E, Collette F, Klimecki OM, Marchant NL, Wirth M, et al. The Age-Well randomized controlled trial of the Medit-Ageing European project: Effect of meditation or foreign language training on brain and mental health in older adults. Alzheimers Dement Transl Res Clin Interv. 2018 Jan 1; 4:714–23. https://doi.org/10.1016/j.trci.2018.10.011 PMID: 30581977
Goldberg SB, Riordan KM, Sun S, Davidson RJ. The Empirical Status of Mindfulness-Based Interventions: A Systematic Review of 44 Meta-Analyses of Randomized Controlled Trials. Perspect Psychol Sci. 2022 Jan 1; 17(1):108–30. https://doi.org/10.1177/1745691620968771 PMID: 33593124
Rosenkranz MA, Dunne JD, Davidson RJ. The next generation of mindfulness-based intervention research: what have we learned and where are we headed? Curr Opin Psychol. 2019 Aug; 28:179–83. https://doi.org/10.1016/j.copsyc.2018.12.022 PMID: 30739006
Van Dam NT, van Vugt MK, Vago DR, Schmalzl L, Saron CD, Olendzki A, et al. Mind the Hype: A Critical Evaluation and Prescriptive Agenda for Research on Mindfulness and Meditation. Perspect Psychol Sci. 2018 Jan 1; 13(1):36–61. https://doi.org/10.1177/1745691617709589 PMID: 29016274
