Article (Scientific journals)
Standardized 4-point scoring scale of [18F]-FDG PET/CT imaging helps in the diagnosis of renal and hepatic cyst infections in patients with autosomal dominant polycystic kidney disease: a validation cohort.
Demuynck, Selina; Lovinfosse, Pierre; Seidel, Laurence et al.
2023In Clinical Kidney Journal, 16 (12), p. 2542 - 2548
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Keywords :
ADPKD, cyst infection, [18F]-FDG PET/CT; standardized scoring system; Transplantation; Nephrology
Abstract :
[en] [en] BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is prone to multiple complications, including cyst infection (CyI). 2-Deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography ([18F]-FDG PET/CT) imaging has proved useful in the diagnosis of renal and hepatic CyI. A 4-point scale comparing the uptake of [18F]-FDG in the suspected infected cyst versus the hepatic physiological background has been recently proposed. We performed an independent validation of this semi-quantitative scoring system. METHODS: All ADPKD patients hospitalized between January 2009 and November 2019 who underwent an [18F]-FDG PET/CT for suspected CyI were retrospectively identified using computer-based databases. Medical files were reviewed. CyI was conventionally defined by the combination of fever (≥38°C), abdominal pain, increased plasma C-reactive protein levels (≥70 mg/L), absence of any other cause of inflammation and favourable outcome after ≥21 days of antibiotics. [18F]-FDG uptake of the suspected CyI was evaluated using a 4-point scale comparing the uptake of [18F]-FDG around the infected cysts with the uptake in the hepatic parenchyma. Statistics were performed using SAS version 9.4. RESULTS: Fifty-one [18F]-FDG PET/CT scans in 51 patients were included, of which 11 were cases of CyI. The agreement between the 4-point scale and the gold-standard criteria of CyI was significant [odds ratio of 6.03 for CyI in case of a score ≥3 (P = .014)]. The corresponding sensitivity, specificity, and positive and negative predictive values of [18F]-FDG PET/CT using the 4-point scale were 64% [Clopper-Pearson 95% confidence interval (CI) 30%-89%], 78% (95% CI 62%-89%), 44% (95% CI 20%-70%) and 89% (95% CI 73%-97%), respectively. CONCLUSIONS: Our independent validation cohort confirms the use of a semi-quantitative 4-point scoring system of [18F]-FDG PET/CT imaging in the diagnosis of CyI in patients with ADPKD. Considering its performance metrics with high specificity and negative predictive value, the scoring system is particularly useful to distinguish other causes of clinical inflammation than CyI and as such avoid unnecessarily long antibiotic treatment.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Demuynck, Selina;  Department of Nephrology, Dialysis and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
Lovinfosse, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco
Seidel, Laurence  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)
Jentjens, Sander;  Nuclear Medicine, UZ Leuven, Leuven, Belgium, Nuclear Medicine & Molecular Imaging, KU Leuven, Leuven, Belgium
Mekahli, Djalila;  PKD Research Group, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium ; Department of Pediatric Nephrology, University Hospitals Leuven, Leuven, Belgium
Jouret, François  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie
Bammens, Bert;  Department of Nephrology, Dialysis and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium ; Department of Microbiology, Immunology and Transplantation, Nephrology & Renal Transplantation Research Group, KU Leuven, Leuven, Belgium
Goffin, Karolien;  Nuclear Medicine, UZ Leuven, Leuven, Belgium, Nuclear Medicine & Molecular Imaging, KU Leuven, Leuven, Belgium
Language :
English
Title :
Standardized 4-point scoring scale of [18F]-FDG PET/CT imaging helps in the diagnosis of renal and hepatic cyst infections in patients with autosomal dominant polycystic kidney disease: a validation cohort.
Publication date :
December 2023
Journal title :
Clinical Kidney Journal
ISSN :
2048-8505
eISSN :
2048-8513
Publisher :
Oxford University Press (OUP), England
Volume :
16
Issue :
12
Pages :
2542 - 2548
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 December 2023

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