Beta-radiation for coronary in-stent restenosis

Stent; Vascular disease; Coronary heart disease; Cardiovascular disease; Arterial disease; Radiotherapy; Instrumentation therapy; Prognosis; Recurrence; Prevention; Treatment efficiency; Beta irradiation; Treatment; Human; Coronary artery; Restenosis; Complication; Endoprosthesis; Vaisseau sanguin pathologie; Cardiopathie coronaire; Radiothérapie; Artère pathologie; Appareil circulatoire pathologie; Récurrence; Pronostic; Traitement instrumental; Irradiation bêta; Efficacité traitement; Prévention; Artère coronaire; Homme; Traitement; Resténose; Endoprothèse

Abstract :

[en] To determine the feasibility and safety of an intracoronary beta-radiation device in preventing the recurrence of in-stent restenosis (ISR) after successful angioplasty, we studied 37 patients treated with beta-radiation (30-mm strontium-90 source) after angioplasty. The mean reference diameter was 2.9 ± 0.5 mm, and 62% of lesions were diffuse, including four total occlusions. Beta-radiation was successfully delivered in 36 of 37 (97%) cases. Over the course of 7.1 ± 4.5 mo follow-up, there were no myocardial infarctions and three deaths: one from preexisting malignancy, one from progressive cardiac failure, and one from sudden cardiac death. Target vessel revascularization (TVR) was performed in seven of 36 (19%) patients. Thirty patients underwent angiography at 6 mo; three (10%) experienced restenosis (diameter stenosis > 50%) at the target site, four (13%) had edge stenoses, and two (7%) had late (> 1 mo) thrombotic occlusions. Beta-radiation for ISR is associated with encouragingly low rates of target lesion restenosis and TVR. Further improvements are needed to solve the limitations of the edge effect and late occlusion.

Disciplines :

Oncology

Author, co-author :

Latchem, D-R

Urban, P

Goy, JJ

De Benedetti, E

COUCKE, Philippe ; Centre Hospitalier Universitaire Vaudois

Pica, A

Eeckhout, E

Language :

English

Title :

Beta-radiation for coronary in-stent restenosis

Publication date :

2000

Journal title :

Catheterization and Cardiovascular Interventions

ISSN :

1522-1946

eISSN :

1522-726X

Publisher :

Wiley Liss, New York, United States - New York

Volume :

Issue :

Pages :

422-429

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 18 February 2010

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