[en] We assessed the dose-dependence of repair of potentially lethal damage in Chinese hamster ovary cells x-irradiated in vitro. The recovery ratio (RR) by which survival (SF) of the irradiated cells was enhanced increased exponentially with a linear and a quadratic component, namely xi and psi: RR = e xi D + psi D2. Survival of irradiated cells can thus be expressed by a combined linear-quadratic model considering four variable, namely alpha and beta for the capacity of the cells to accumulate sublethal damage, and xi and psi for their capacity to repair potentially lethal damage: SF = e(xi - alpha)D + (psi - beta)D2. [fr] We assessed the dose-dependence of repair of potentially lethal damage in Chinese hamster ovary cells x-irradiated in vitro. Nous avons évalué la dose-dépendance de la réparation des dommages potentiellement mortelles dans des cellules ovariennes de hamster chinois x-irradiées in vitro. The recovery ratio (RR) by which survival (SF) of the irradiated cells was enhanced increased exponentially with a linear and a quadratic component, namely xi and psi: RR = e xi D + psi D2. Le taux de récupération (RR), par lequel survie (SF) des cellules irradiées a été renforcée augmenté de façon exponentielle avec un savoir linéaire et une composante du second degré, XI et PSI: RR = D + E xi psi D2. Survival of irradiated cells can thus be expressed by a combined linear-quadratic model considering four variable, namely alpha and beta for the capacity of the cells to accumulate sublethal damage, and xi and psi for their capacity to repair potentially lethal damage: SF = e(xi - alpha)D + (psi - beta)D2. La survie des cellules irradiées peut donc être exprimé par un modèle combiné linéaire-quadratique elle dégage quatre variables, à savoir alpha et bêta, pour la capacité des cellules à accumuler des dommages sublétaux et xi et psi pour leur capacité à réparer les dommages potentiellement mortelle: SF = E (xi - alpha) D + (psi - bêta) D2.
Disciplines :
Oncology
Author, co-author :
Rutz, HP
COUCKE, Philippe ; Centre Hospitalier Universitaire Vaudois (Lausanne) > Radiothérapie
Mirimanoff, RO; Centre Hospitalier Universitaire Vaudois > Laboratoire de Radiobiologie
Language :
English
Title :
A linear-quadratic model of cell survival considering both sublethal and potentially lethal radiation damage
Alternative titles :
[fr] Un modèle linéaire-quadratique de la survie cellulaire considérant à la fois sublétale et potentiellement mortelle d'irradiation dégâts
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