[en] [en] BACKGROUND: Physical activity and exercise have been suggested as effective interventions for the prevention and management of mild cognitive impairment (MCI) and dementia, but there are no international guidelines.
OBJECTIVES: To create a set of evidence- and expert consensus-based prevention and management recommendations regarding physical activity (any bodily movement produced by skeletal muscles that results in energy expenditure) and exercise (a subset of physical activity that is planned, structured, repetitive), applicable to a range of individuals from healthy older adults to those with MCI/dementia.
METHODS: Guideline content was developed with input from several scientific and lay representatives' societies. A systematic search across multidisciplinary databases was carried out until October 2021. Recommendations for prevention and management were developed according to the GRADE and complemented by consensus statements from the expert panels.
RECOMMENDATIONS: Physical activity may be considered for the primary prevention of dementia. In people with MCI there is continued uncertainty about the role of physical activity in slowing the conversion to dementia. Mind-body interventions have the greatest supporting evidence. In people with moderate dementia, exercise may be used for maintaining disability and cognition. All these recommendations were based on a very low/low certainty of evidence.
CONCLUSIONS: Although the scientific evidence on the beneficial role of physical activity and exercise in preserving cognitive functions in subjects with normal cognition, MCI or dementia is inconclusive, this panel, composed of scientific societies and other stakeholders, recommends their implementation based on their beneficial effects on almost all facets of health.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Veronese, Nicola; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Via del Vespro, 141, 90127, Palermo, Italy. nicola.veronese@unipa.it
Soysal, Pinar; Faculty of Medicine, Department of Geriatric Medicine, Bezmialem Vakif University, Istanbul, Turkey
Demurtas, Jacopo; Clinical and Experimental Medicine PhD Program, Università di Modena e Reggio Emilia, Modena - Azienda USL Sud Est Toscana, Grosseto, Italy
Solmi, Marco; Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada ; Department of Mental Health, The Ottawa Hospital, Ottawa, ON, Canada ; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany
Bruyère, Olivier ; Université de Liège - ULiège > Unité de recherche Santé publique, épidémiologie et économie de la santé (URSAPES)
Christodoulou, Nikos; Department of Psychiatry, University of Thessaly Medical School, Volos, Greece ; World Psychiatric Association, Section of Preventive Psychiatry, University of Nottingham Medical School, Nottingham, UK
Ramalho, Rodrigo; Department of Social and Community Health, School of Population Health, The University of Auckland, Auckland, New Zealand
Fusar-Poli, Paolo; Department of Psychosis Studies, King's College London, London, UK ; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
Lappas, Andreas S; Faculty of Medicine, Department of Psychiatry, University of Thessaly, Larissa, Greece ; Aneurin Bevan University Health Board, Newport, Wales, UK
Pinto, Daniel ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé ; Department of Physical Therapy, College of Health Sciences, Marquette University, Milwaukee, WI, USA
Frederiksen, Kristian Steen; Department of Neurology, Danish Dementia Research Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
Corbi, Grazia Maria; Department of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy
Karpenko, Olga; Chair of the WPA Preventive Psychiatry Section, Mental-Health Clinic No. 1 Named After N.A. Alexeev, Moscow, Russia
Durães, João; Neurology Department, Coimbra University Hospital Centre, Coimbra, Portugal ; Faculty of Medicine, Coimbra University, Coimbra, Portugal
Schlögl, Mathias; Division of Geriatric Medicine, Clinic Barmelweid, Barmelweid, Switzerland
Yilmaz, Ozlem; Department of Geriatric Medicine, Istanbul Training and Research Hospital, Samatya, Istanbul, Turkey
Sieber, Cornel; Institute for Biomedicine of Aging, Friedrich-Alexander-Universität Erlangen-Nürnberg, Kobergerstr. 60, 90408, Nuremberg, Germany ; Department of Medicine, Kantonsspital Winterthur, Brauerstrasse 15, Postfach 834, 8401, Winterthur, Zurich, Switzerland
Shenkin, Susan D; Ageing and Health Research Group and Advanced Care Research Centre, Usher Institute, University of Edinburgh, Edinburgh, Scotland, UK
Smith, Lee; Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique
Maggi, Stefania; National Research Council, Neuroscience Institute, Aging Branch, Padua, Italy
Limongi, Federica; National Research Council, Neuroscience Institute, Aging Branch, Padua, Italy
Ars, Joan; RE-FiT Barcelona Research Group, Vall d'Hebron Institute of Research (VHIR) and Parc Sanitari Pere Virgili, Barcelona, Spain ; Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet and Stockholm University, Stockholm, Sweden
Barbagallo, Mario; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Via del Vespro, 141, 90127, Palermo, Italy
Cherubini, Antonio; Geriatria, Accettazione Geriatrica e Centro di Ricerca Per l'invecchiamento, IRCCS INRCA, Ancona, Italy
Quinn, Terry; Department of Geriatric Medicine, Glasgow Royal Infirmary, Glasgow, UK ; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
Alzheimer Europe
European College of Neuropsychopharmacology
European Geriatric Medicine Society (Lead Society)
European Interdisciplinary Council on Ageing
European Society of Clinical and Economic Aspects of Osteoporosis and Osteoarthritis
International Association of Gerontology and Geriatrics-European Region
Scottish Brain Health ARC
World Psychiatry Association-Preventive Psychiatry Section
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