Article (Scientific journals)
Testing biological actions of medicinal plants from northern Vietnam on zebrafish embryos and larvae: Developmental, behavioral, and putative therapeutical effects.
Tran, My Hanh; Nguyen, Thi Van Anh; Do, Hoang Giang et al.
2023In PLoS ONE, 18 (11), p. 0294048
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Keywords :
Plant Extracts; Animals; Humans; Mice; Zebrafish/genetics; Larva; Vietnam; Plant Extracts/pharmacology; Plant Extracts/chemistry; Embryo, Nonmammalian; Mammals; Plants, Medicinal; Multidisciplinary
Abstract :
[en] Evaluating the risks and benefits of using traditional medicinal plants is of utmost importance for a huge fraction of the human population, in particular in Northern Vietnam. Zebrafish are increasingly used as a simple vertebrate model for testing toxic and physiological effects of compounds, especially on development. Here, we tested 12 ethanolic extracts from popular medicinal plants collected in northern Vietnam for their effects on zebrafish survival and development during the first 4 days after fertilization. We characterized more in detail their effects on epiboly, hatching, growth, necrosis, body curvature, angiogenesis, skeletal development and mostly increased movement behavior. Finally, we confirm the effect on epiboly caused by the Mahonia bealei extract by staining the actin filaments and performing whole genome gene expression analysis. Further, we show that this extract also inhibits cell migration of mouse embryo fibroblasts. Finally, we analyzed the chemical composition of the Mahonia bealei extract and test the effects of its major components. In conclusion, we show that traditional medicinal plant extracts are able to affect zebrafish early life stage development to various degrees. In addition, we show that an extract causing delay in epiboly also inhibits mammalian cell migration, suggesting that this effect may serve as a preliminary test for identifying extracts that inhibit cancer metastasis.
Disciplines :
Veterinary medicine & animal health
Pharmacy, pharmacology & toxicology
Author, co-author :
Tran, My Hanh;  Laboratory for Organogenesis and Regeneration, GIGA I3, Université de Liège, Liège, Belgium ; Department of Microbiology, Vietnam National University of Science, Faculty of Biology, Hanoi, Vietnam
Nguyen, Thi Van Anh;  Department of Microbiology, Vietnam National University of Science, Faculty of Biology, Hanoi, Vietnam
Do, Hoang Giang ;  Center for Research and Technology Transfer, Vietnam Academy of Science and Technology, Hanoi, Vietnam
Kieu, Trung Kien ;  GREENLAB, Center for Life Science Research (CELIFE), Vietnam National University of Science, Faculty of Biology, Hanoi, Vietnam
Nguyen, Thi Kim Thanh;  Department of Plant Science, Vietnam National University of Science, Faculty of Biology, Hanoi, Vietnam
Le, Hong Diep;  Department of Plant Science, Vietnam National University of Science, Faculty of Biology, Hanoi, Vietnam
Guerrero Limon, Gustavo  ;  Université de Liège - ULiège > GIGA
Massoz, Laura  ;  Université de Liège - ULiège > GIGA > GIGA Stem Cells - Zebrafish Development and Disease Model
Nivelle, Renaud ;  Université de Liège - ULiège > Département de Biologie, Ecologie et Evolution > Gestion des ressources aquatiques et aquaculture
Zappia, Jérémie ;  Université de Liège - ULiège > Unités de recherche interfacultaires > Centre Interdisciplinaire de Recherche sur le Médicament (CIRM)
Pham, Hai The ;  Department of Microbiology, Vietnam National University of Science, Faculty of Biology, Hanoi, Vietnam ; GREENLAB, Center for Life Science Research (CELIFE), Vietnam National University of Science, Faculty of Biology, Hanoi, Vietnam
Nguyen, Lai Thanh;  GREENLAB, Center for Life Science Research (CELIFE), Vietnam National University of Science, Faculty of Biology, Hanoi, Vietnam
Muller, Marc  ;  Université de Liège - ULiège > Département des sciences de la vie
More authors (3 more) Less
Language :
English
Title :
Testing biological actions of medicinal plants from northern Vietnam on zebrafish embryos and larvae: Developmental, behavioral, and putative therapeutical effects.
Publication date :
07 November 2023
Journal title :
PLoS ONE
eISSN :
1932-6203
Publisher :
Public Library of Science (PLoS), United States
Volume :
18
Issue :
11
Pages :
e0294048
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
FP7 People: Marie-Curie Actions
Funders :
ARES - Académie de Recherche et d'Enseignement Supérieur [BE]
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
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