[en] The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneously hypertensive rat and the normotensive control strain Wistar-Kyoto have led to the localization of two genes, BP/SP-1 and BP/SP-2, that contribute significantly to blood pressure variation in the F2 population. BP/SP-1 and BP/SP-2 were assigned to rat chromosomes 10 and X, respectively. Comparison of the human and rat genetic maps indicates that BP/SP-1 could reside on human chromosome 17q in a region that also contains the angiotensin I-converting enzyme gene (ACE). This encodes a key enzyme of the renin-angiotensin system, and is therefore a candidate gene in primary hypertension. A rat microsatellite marker of ACE was mapped to rat chromosome 10 within the region containing BP/SP-1.
Disciplines :
Genetics & genetic processes
Author, co-author :
Hilbert, P; Centre d'Etude du Polymorphisme Humain, Paris, France
Lindpaintner, K
Beckmann, J S
Serikawa, T
Soubrier, F
Dubay, C
Cartwright, P
De Gouyon, B
Julier, C
Takahasi, S
Vincent, M
Gante, D
Georges, Michel ; Université de Liège - ULiège > Département de gestion vétérinaire des Ressources Animales (DRA) ; Université de Liège - ULiège > GIGA > GIGA Medical Genomics - Unit of Animal Genomics