Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats.

Hilbert, P; Lindpaintner, K; Beckmann, J S; Serikawa, T; Soubrier, F; Dubay, C; Cartwright, P; De Gouyon, B; Julier, C; Takahasi, S; Vincent, M; Gante, D; Georges, Michel; Lathrop, G.M.

doi:10.1038/353521a0

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Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats.

Hilbert, P; Lindpaintner, K; Beckmann, J S et al.

1991 • In Nature, 353 (6344), p. 521 - 529

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https://hdl.handle.net/2268/309563

DOI
10.1038/353521a0

PubMed
1656270

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Keywords :

Receptors, Cell Surface; Receptors, Nerve Growth Factor; Receptors, Somatotropin; Peptidyl-Dipeptidase A; Animals; Base Sequence; Chromosome Mapping; Genetic Linkage; Hypertension/genetics; Molecular Sequence Data; Peptidyl-Dipeptidase A/genetics; Polymerase Chain Reaction; Rats; Rats, Inbred SHR/genetics; Rats, Inbred WKY/genetics; Receptors, Cell Surface/genetics; Receptors, Somatotropin/genetics; X Chromosome; Multidisciplinary

Abstract :

[en] The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneously hypertensive rat and the normotensive control strain Wistar-Kyoto have led to the localization of two genes, BP/SP-1 and BP/SP-2, that contribute significantly to blood pressure variation in the F2 population. BP/SP-1 and BP/SP-2 were assigned to rat chromosomes 10 and X, respectively. Comparison of the human and rat genetic maps indicates that BP/SP-1 could reside on human chromosome 17q in a region that also contains the angiotensin I-converting enzyme gene (ACE). This encodes a key enzyme of the renin-angiotensin system, and is therefore a candidate gene in primary hypertension. A rat microsatellite marker of ACE was mapped to rat chromosome 10 within the region containing BP/SP-1.

Disciplines :

Genetics & genetic processes

Author, co-author :

Hilbert, P; Centre d'Etude du Polymorphisme Humain, Paris, France

Lindpaintner, K

Beckmann, J S

Serikawa, T

Soubrier, F

Dubay, C

Cartwright, P

De Gouyon, B

Julier, C

Takahasi, S

More authors (4 more)

Language :

English

Title :

Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats.

Publication date :

10 October 1991

Journal title :

Nature

ISSN :

0028-0836

eISSN :

1476-4687

Publisher :

Springer Science and Business Media LLC, England

Volume :

353

Issue :

6344

Pages :

521 - 529

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.nature.com/articles/353521a0

Available on ORBi :

since 06 December 2023

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