Allergic rhinitis; Asthma; Mobile health; Quality of life; Immunology and Allergy
Abstract :
[en] [en] BACKGROUND: EQ-5D-5L (EuroQOL, 5 Domains, 5 Levels) is a widely used health-related quality-of-life instrument, comprising 5 domains. However, it is not known how each domain is impacted by rhinitis or asthma control.
OBJECTIVE: To assess the association between rhinitis or asthma control and the different EQ-5D-5L domains using data from the MASK-air mHealth app.
METHODS: In this cross-sectional study, we assessed data from all MASK-air users (2015-2021; 24 countries). For the levels of each EQ-5D-5L domain, we assessed rhinitis and asthma visual analog scales (VASs) and the combined symptom-medication score (CSMS). We built ordinal multivariable models assessing the adjusted association between VAS/CSMS values and the levels of each EQ-5D-5L domain. Finally, we compared EQ-5D-5L data from users with rhinitis and self-reported asthma with data from users with rhinitis alone.
RESULTS: We assessed 5354 days from 3092 users. We observed an association between worse control of rhinitis or asthma (higher VASs and CSMS) and worse EQ-5D-5L levels. In multivariable models, all VASs and the CSMS were associated with higher levels of pain/discomfort and daily activities. For anxiety/depression, the association was mostly observed for rhinitis-related tools (VAS nose, VAS global, and CSMS), although the presence of self-reported asthma was also associated with worse anxiety/depression. Worse mobility ("walking around") was particularly associated with VAS asthma and with the presence of asthma.
CONCLUSIONS: A worse rhinitis control and a worse asthma control are associated with higher EQ-5D-5L levels, particularly regarding pain/discomfort and activity impairment. Worse rhinitis control is associated with worse anxiety/depression, and poor asthma control with worse mobility.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Sousa-Pinto, Bernardo ✱; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal, CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal
Louis, Gilles ✱; Université de Liège - ULiège > Santé publique : de la Biostatistique à la Promotion de la Santé
Rodrigues, Jorge; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal, CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal, Otorhinolaryngology Department, Centro Hospitalar Universitário de S João, EPE, Porto, Portugal, Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal
Giuliano, Antonio Francesco Maria; Department of Internal Medicine 'A. Murri' and Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy
Baiardini, Ilaria; Respiratory Clinic, Department of Internal Medicine, University of Genoa, Genoa, Italy, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
Braido, Fulvio; Respiratory Clinic, Department of Internal Medicine, University of Genoa, Genoa, Italy, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
Czarlewski, Wienczyslawa; Medical Consulting Czarlewski, Levallois, France, MASK-air, Montpellier, France
Bedbrook, Anna; MASK-air, Montpellier, France, ARIA, Montpellier, France
Haahtela, Tari; Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
Valiulis, Arunas; Interdisciplinary Research Group of Human Ecology, Institute of Clinical Medicine and Institute of Health Sciences, Medical Faculty of Vilnius University, Vilnius, Lithuania, European Academy of Paediatrics, (EAP/UEMS-SP), Brussels, Belgium
Brussino, Luisa; Department of Medical Sciences, University of Torino, Torino, Italy, Allergy and Clinical Immunology Unit, Mauriziano Hospital, Torino, Italy
Cecchi, Lorenzo; SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy
Cruz, Alvaro A; Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Bahia, Brazil
Gemicioglu, Bilun; Department of Pulmonary Diseases, Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Istanbul, Turkey
Fokkens, Wytske J; Department of Otorhinolaryngology, Amsterdam University Medical Centres, Amsterdam, the Netherlands
Ivancevich, Juan Carlos; Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina
Klimek, Ludger; Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany, Center for Rhinology and Allergology, Wiesbaden, Germany
Kraxner, Helga; Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary
Kuna, Piotr; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
Kupczyk, Maciej; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
Kvedariene, Violeta; Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania, Department of Pathology, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
Larenas-Linnemann, Désirée; Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico
Louis, Renaud ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Nadif, Rachel; Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Villejuif, France, Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France
Niedoszytko, Marek; Department of Allergology, Medical University of Gdańsk, Gdansk, Poland
Okamoto, Yoshitaka; Chiba Rosai Hospital, Chiba, Japan, Chiba University Hospital, Chiba, Japan
Ollert, Markus; Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg, Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark, Odense Research Center for Anaphylaxis (ORCA), Odense, Denmark
Papadopoulos, Nikolaos G; Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
Patella, Vincenzo; Division of Allergy and Clinical Immunology, Department of Medicine, "Santa Maria della Speranza" Hospital, Battipaglia, Salerno, Italy, Agency of Health ASL, Salerno, Italy, Postgraduate Programme in Allergy and Clinical Immunology, University of Naples Federico II, Naples, Italy
Pawankar, Ruby; Department of Pediatrics, Nippon Medical School, Tokyo, Japan
Pham-Thi, Nhân; Ecole Polytechnique de Palaiseau, Palaiseau, France, IRBA (Institut de Recherche Bio-Médicale des Armées), Brétigny sur Orge, France, Université Paris Cité, Paris, France
Pfaar, Oliver; Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany
Regateiro, Frederico S; Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, Center for Innovative Biomedicine and Biotechnology (CIBB), Faculty of Medicine, University of Coimbra, Coimbra, Portugal, Institute of Immunology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal, UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
Roche, Nicolas; Pneumologie, AP-HP Centre Université de Paris Cité, Hôpital Cochin, Paris, France, UMR 1016, Institut Cochin, Paris, France
Rouadi, Philip W; Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon, Department of Otorhinolaryngology-Head and Neck Surgery, Dar Al Shifa Hospital, Salmiya, Kuwait
Samolinski, Boleslaw; Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland
Sastre, Joaquin; Allergy Service, Fundacion Jimenez Diaz, Autonoma University of Madrid, CIBERES-ISCIII, Madrid, Spain
Savouré, Marine; Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Villejuif, France, Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France
Scichilone, Nicola; PROMISE Department, University of Palermo, Palermo, Italy
Sheikh, Aziz; Usher Institute, the University of Edinburgh, Edinburgh, United Kingdom
Taborda-Barata, Luís; Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal, UBIAir-Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
Toppila-Salmi, Sanna; Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
Yorgancioglu, Arzu; Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa, Turkey
Zidarn, Mihaela; University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia, University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia
Anto, Josep M; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Zuberbier, Torsten; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany, Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Canonica, G Walter; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Ventura, Maria Teresa; Department of Internal Medicine 'A. Murri' and Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy, Institute of Sciences of Food Production, National Research Council (ISPA-CNR), Bari, Italy
Fonseca, João A; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal, CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal
Pétré, Benoît ; Université de Liège - ULiège > Département des sciences de la santé publique > Education thérapeutique du patient au service des soins intégrés
Bousquet, Jean; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany, Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. Electronic address: jean.bousquet@orange.fr
This study was partly funded by a grant from the University of Liège , Belgium. MASK-air has been supported by EU grants (POLLAR, EIT Health; Structural and Development Funds, Région Languedoc Roussillon and PACA; Twinning, EIP on AHA, DG Santé, and DG Connect; H2020 and Horizon Europe) and educational grants from Mylan-Viatris , ALK, GSK, Novartis, and Uriach.
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