Brain; Connectome; Humans; Magnetic Resonance Imaging; Sleep; Sleep Initiation and Maintenance Disorders; Chemistry (all); Biochemistry, Genetics and Molecular Biology (all); Physics and Astronomy (all); General Physics and Astronomy; General Biochemistry, Genetics and Molecular Biology; General Chemistry; Multidisciplinary
Abstract :
[en] Sleep health is both conceptually and operationally a composite concept containing multiple domains of sleep. In line with this, high dependence and interaction across different domains of sleep health encourage a transition in sleep health research from categorical to dimensional approaches that integrate neuroscience and sleep health. Here, we seek to identify the covariance patterns between multiple sleep health domains and distributed intrinsic functional connectivity by applying a multivariate approach (partial least squares). This multivariate analysis reveals a composite sleep health dimension co-varying with connectivity patterns involving the attentional and thalamic networks and which appear relevant at the neuromolecular level. These findings are further replicated and generalized to several unseen independent datasets. Critically, the identified sleep-health related connectome shows diagnostic potential for insomnia disorder. These results together delineate a potential brain connectome biomarker for sleep health with high potential for clinical translation.
Disciplines :
Neurosciences & behavior
Author, co-author :
Wang, Yulin ; Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China ; Key Laboratory of Cognition and Personality, Ministry of Education, Faculty of Psychology, Southwest University, Chongqing, China
Genon, Sarah ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et revalidation cognitive ; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany ; Institute for Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Dong, Debo ; Key Laboratory of Cognition and Personality, Ministry of Education, Faculty of Psychology, Southwest University, Chongqing, China ; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany
Zhou, Feng; Key Laboratory of Cognition and Personality, Ministry of Education, Faculty of Psychology, Southwest University, Chongqing, China
Li, Chenyu; Sleep Center, Department of Brain Disease, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China
Yu, Dahua; Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, China
Yuan, Kai; School of Life Science and Technology, Xidian University, Xi’an, China
He, Qinghua ; Key Laboratory of Cognition and Personality, Ministry of Education, Faculty of Psychology, Southwest University, Chongqing, China
Qiu, Jiang; Key Laboratory of Cognition and Personality, Ministry of Education, Faculty of Psychology, Southwest University, Chongqing, China
Feng, Tingyong ; Key Laboratory of Cognition and Personality, Ministry of Education, Faculty of Psychology, Southwest University, Chongqing, China
Chen, Hong; Key Laboratory of Cognition and Personality, Ministry of Education, Faculty of Psychology, Southwest University, Chongqing, China
Lei, Xu ; Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China ; Key Laboratory of Cognition and Personality, Ministry of Education, Faculty of Psychology, Southwest University, Chongqing, China
Language :
English
Title :
Covariance patterns between sleep health domains and distributed intrinsic functional connectivity
NSCF - National Natural Science Foundation of China [CN]
Funding text :
This work has been funded by the National Key Research and Development Program of China (2021YFC2501500, X.L.), the National Natural Science Foundation of China (31971028, X.L.; 82202247, D.B.D.; 32300861, Y.L.W.), and 2021 International Exchange Program and Introduction Project Funding awarded to Y.L.W.
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