Article (Scientific journals)
Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA.
Efficace, Fabio; Al Essa, Wael; Platzbecker, Uwe et al.
2023In HemaSphere, 7 (9), p. 944
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Keywords :
Hematology
Abstract :
[en] Health-related quality of life (HRQoL) is an important goal of therapy for patients with myelodysplastic syndromes (MDS); however, little is known about HRQoL of these patients at clinical presentation. We report HRQoL profile of newly diagnosed patients with MDS across both the the International Prognostic Scoring System (IPSS) and IPSS-Revised (IPSS-R) classifications, stratified by sex and age group categories, aiming to also establish European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core30 (EORTC QLQ-C30) reference values for these patients. Analysis was based on 927 patients with a median age of 73.3 years (interquartile range, 66.0-79.2), of whom 506 and 421 with lower- and higher-risk disease respectively, according to the IPSS classification. HRQoL was assessed with the EORTC QLQ-C30 and substantial differences by age groups and sex, between and within lower- and higher-risk disease categories were observed. For example, within higher-risk disease patients, the youngest group (ie, 30-59 years) tended to report clinically meaningful worse outcomes across various functional and symptom domains compared with older age groups. We also developed 2 regression models allowing for the prediction of EORTC QLQ-C30 reference scores for patients classified according to either the IPSS or the IPSS-R. Investigation of prevalence rates for clinically important problems and symptoms at diagnosis revealed a substantial burden of the disease with >50% of patients reporting clinically important problems with physical functioning and dyspnea in both lower- and higher-risk disease. Our findings may help to enhance the interpretation of HRQoL outcomes in future MDS studies and to better contextualize HRQoL data from routine practice settings.
Disciplines :
Hematology
Author, co-author :
Efficace, Fabio;  Data Center and Health Outcomes Research Unit, Italian Group for Adult Haematologic Diseases (GIMEMA), Rome, Italy
Al Essa, Wael;  Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
Platzbecker, Uwe;  Clinic and Policlinic of Hematology and Cellular Therapy, Oncology and Hemostaseology, University Hospital Leipzig, Germany
Niscola, Pasquale;  Hematology Unit, Sant'Eugenio Hospital, Rome, Italy
Palumbo, Giuseppe A;  Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate "G.F. Ingrassia," University of Catania, Italy
Caocci, Giovanni;  Department of Medical Sciences and Public Health, University of Cagliari, Italy
Cottone, Francesco;  Data Center and Health Outcomes Research Unit, Italian Group for Adult Haematologic Diseases (GIMEMA), Rome, Italy
Breccia, Massimo;  Hematology, Department of Translational and Precision Medicine, Azienda Ospedaliera Policlinico Umberto I, Sapienza University of Rome, Italy
Luppi, Mario;  University of Modena and Reggio Emilia, AOU Modena, Italy
Stauder, Reinhard;  Department of Internal Medicine V (Hematology and Oncology), Innsbruck Medical University, Innsbruck, Austria
Ricco, Alessandra;  Hematology and Transplants Unit, University of Bari, Italy
Petranovic, Duska;  Department of Hematology, Clinical Hospital Center Rijeka, Croatia
Baron, Frédéric  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Voso, Maria Teresa;  Department of Biomedicine and Prevention, University of Rome Tor Vergata, Italy
Fianchi, Luana;  Dipartimento Scienze Radiologiche Radioterapiche ed Ematologiche, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma, Italy
Frairia, Chiara;  Department of Oncology, Division of Hematology, AOU Città della Salute e della Scienza, Turin, Italy
Capodanno, Isabella;  Hematology Unit, Azienda Unità Sanitaria Locale-IRCCS, Reggio Emilia, Italy
Sarlo, Chiara;  Hematology and Stem Cell Transplantation Unit, University Campus Bio-Medico, Rome, Italy
Fedele, Marilena;  Hematology, Ospedale San Gerardo, Monza, Italy
Lemoli, Roberto Massimo;  Cattedra di ematologia, Dipartimento di Medicina Interna (DiMI), Università di Genova, Italy ; Clinica Ematologica, IRCCS Policlinico San Martino, Genova, Italy
Invernizzi, Rosangela;  Department of Internal Medicine, San Matteo IRCCS Policlinic Foundation, University of Pavia, Italy
Vallisa, Daniele;  Ematologia, Ospedale di Piacenza, Italy
Di Renzo, Nicola;  Hematology and Stem Cell Transplant Unit, "Vito Fazzi" Hospital, Lecce, Italy
Fozza, Claudio;  Department of Medicine, Surgery, and Pharmacy, University of Sassari, Italy
Doro, Maribel;  Unidade de Hematologia, Hemoterapia e Oncologia (UHHO), Serviço de Transplante de Medula Óssea (STMO), Complexo Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil
Giesinger, Johannes M;  University Hospital of Psychiatry II, Medical University of Innsbruck, Austria
Vignetti, Marco;  Data Center and Health Outcomes Research Unit, Italian Group for Adult Haematologic Diseases (GIMEMA), Rome, Italy
More authors (17 more) Less
Language :
English
Title :
Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA.
Publication date :
September 2023
Journal title :
HemaSphere
eISSN :
2572-9241
Publisher :
Wolters Kluwer Health, United States
Volume :
7
Issue :
9
Pages :
e944
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 November 2023

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