[en] [en] BACKGROUND: IBD is associated with an increased risk of developing lymphoma. Although recent data clarifies lymphoma epidemiology in IBD patients, clinical and pathological characteristics of lymphoma occurring in IBD remain ill-known.
METHODS: Patients with IBD and lymphoma were retrospectively identified in the framework of a national collaborative study including the Groupe d'Étude Thérapeutique des Affections Inflammatoires du Tube Digestif (GETAID) and the Lymphoma Study Association (LYSA). We characterized clinical and prognostic features for the 3 most frequent lymphoma subtypes occurring in IBD. We performed a multicentric case-control study. Controls (lymphoma de novo) were matched (5:1) to cases on gender, age at diagnosis, lymphoma subtype, year of diagnosis, IPI/FLIPI indexes. Overall survival (OS) and progression free survival were compared between cases and controls.
RESULTS: 133 IBD patients with lymphoma were included (males = 62.4 %, median age at lymphoma diagnosis = 49 years in males ; 42 in females). Most had Crohn's disease (73.7 %) and were exposed to thiopurines (59.4 %). The most frequent lymphoma subtypes were diffuse large B cell lymphoma (DLBCL, 45.1 %), Hodgkin lymphoma (HL, 18.8 %), and follicular lymphoma (FL, 10.5 %). When matched with 365 controls, prognosis was improved in IBD patients with DLBCL compared to controls (p = 0.0064, hazard ratio = 0.36) or similar (HL and FL).
CONCLUSION: Lymphomas occurring in IBD patients do not seem to have a worse outcome than in patients without IBD. Due to the scarcity of this situation, those patients should be managed in expert centers.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Muller, Marie ; Department of Gastroenterology, Nancy University Hospital, University of Lorraine, Nancy, France
Broséus, Julien; University of Lorraine, Inserm U1256 « Nutrition - Genetics and exposure to environmental risks - NGERE », F-54000, Nancy, France ; University of Lorraine, CHRU-Nancy Hematology Laboratory, Laboratory department, F-54000 Nancy, France
Guilloteau, Adrien; Registre des hemopathies Malignes de Côte d'Or, Inserm U1231, University of Burgundy and Dijon University Hospital, Dijon, France
Wasse, Stéphane; Registre des hemopathies Malignes de Côte d'Or, Inserm U1231, University of Burgundy and Dijon University Hospital, Dijon, France
Thiéblemont, Catherine; AP-HP, Saint-Louis Hospital, Hemato-oncology, University of Paris, Paris, France
Nancey, Stéphane; Department of Gastroenterology, University Claude Bernard Lyon 1, Hospices Civils de Lyon, CHU Lyon-Sud, Lyon, France
Cadiot, Guillaume; Department of Hepato-Gastro-Enterology, Reims University Hospital, France
Amiot, Aurélien; Department of Gastroenterology, Henri Mondor University Hospital, AP-HP, Paris Est Créteil University, Créteil, France
Laharie, David; Department of Hepato-Gastro-Enterology, Bordeaux University Hospital, Pessac, France
Vieujean, Sophie ; Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive
Bouhnik, Yoram; Institut National de la Santé et Recherche Médicale et Université Paris Diderot, Paris Hôpital Beaujon, AP-HP, Paris, France
Martineau, Chloé; Department of Gastroenterology, Hôpital Européen George Pompidou, AP-HP, Paris, France
Michiels, Christophe; Department of Hepato-Gastro-Enterology, Dijon University Hospital, France
Hebuterne, Xavier; Department of Hepato-Gastro-Enterology, Nice University Hospital, France
Savoye, Guillaume; Department of Hepato-Gastro-Enterology, Rouen University Hospital, France
Franchimont, Denis; Department of Hepato-Gastro-Enterology, Erasme University Hospital, Brussels, Belgium
Seksik, Philippe; Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpital Saint-Antoine, Department of Gastroenterology, F75012, Paris, France
Beaugerie, Laurent; Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpital Saint-Antoine, Department of Gastroenterology, F75012, Paris, France
Maynadié, Marc; Registre des hemopathies Malignes de Côte d'Or, Inserm U1231, University of Burgundy and Dijon University Hospital, Dijon, France
Feugier, Pierre; University of Lorraine, Inserm U1256 « Nutrition - Genetics and exposure to environmental risks - NGERE », F-54000, Nancy, France ; Department of Clinical Hematology, Nancy University Hospital, University of Lorraine, Nancy, France
Peyrin-Biroulet, Laurent; Department of Gastroenterology, Nancy University Hospital, University of Lorraine, Nancy, France ; University of Lorraine, Inserm U1256 « Nutrition - Genetics and exposure to environmental risks - NGERE », F-54000, Nancy, France
