[en] [en] BACKGROUND: Young autosomal dominant polycystic kidney disease (ADPKD) patients are becoming the new target population for the development of new treatment options. Determination of a reliable equation for estimated glomerular filtration rate (eGFR) from early stages is needed with the promising potential interventional therapies.
METHODS: Prospective and longitudinal study on a cohort of 68 genotyped ADPKD patients (age range 0-23 years) with long-term follow-up. Commonly used equations for eGFR were compared for their relative performance.
RESULTS: The revised Schwartz formula (CKiD) showed a highly significant decline in eGFR with aging (- 3.31 mL/min/1.73 m2/year, P < 0.0001). The recently updated equation by the Schwartz group (CKiDU25) showed a smaller (- 0.90 mL/min/1.73 m2/year) but significant (P = 0.001) decline in eGFR with aging and also showed a significant sex difference (P < 0.0001), not observed by the other equations. In contrast, the full age spectrum (FAS) equations (FAS-SCr, FAS-CysC, and the combined) showed no age and sex dependency. The prevalence of hyperfiltration is highly dependent on the formula used, and the highest prevalence was observed with the CKiD Equation (35%).
CONCLUSIONS: The most widely used methods to calculate eGFR in ADPKD children (CKiD and CKiDU25 equations) were associated with unexpected age or sex differences. The FAS equations were age- and sex-independent in our cohort. Hence, the switch from the CKiD to CKD-EPI equation at the transition from pediatric to adult care causes implausible jumps in eGFR, which could be misinterpreted. Having reliable methods to calculate eGFR is indispensable for clinical follow-up and clinical trials. A higher resolution version of the Graphical abstract is available as Supplementary information.
Disciplines :
Urology & nephrology Pediatrics
Author, co-author :
Schellekens, Pieter; PKD Research Group, Department of Cellular and Molecular Medicine, KU Leuven, Louvain, Belgium ; Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Louvain, Belgium ; Department of Nephrology, Dialysis and Renal Transplantation, University Hospitals Leuven, Louvain, Belgium
Verjans, Marcelien; Department of Pediatric Nephrology, University Hospitals Leuven, Louvain, Belgium
Janssens, Peter; PKD Research Group, Department of Cellular and Molecular Medicine, KU Leuven, Louvain, Belgium ; Department of Nephrology and Arterial Hypertension, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel, Brussels, Belgium
Dachy, Angélique ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie ; PKD Research Group, Department of Cellular and Molecular Medicine, KU Leuven, Louvain, Belgium ; Department of Pediatrics, U Liège Academic Hospital, Liège, Belgium
De Rechter, Stéphanie; PKD Research Group, Department of Cellular and Molecular Medicine, KU Leuven, Louvain, Belgium ; Department of Pediatric Nephrology, University Hospitals Leuven, Louvain, Belgium
Breysem, Luc; Department of Radiology, University Hospitals Leuven, Louvain, Belgium
Allegaert, Karel; Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000, Louvain, Belgium ; Woman and Child, Department of Development and Regeneration, KU Leuven, 3000, Louvain, Belgium ; Department of Clinical Pharmacy, Erasmus MC, 3000, CA, Rotterdam, the Netherlands
Bammens, Bert; Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Louvain, Belgium ; Department of Nephrology, Dialysis and Renal Transplantation, University Hospitals Leuven, Louvain, Belgium
Vennekens, Rudi; Department of Cellular and Molecular Medicine, VIB Centre for Brain and Disease Research, Laboratory of Ion Channel Research, KU Leuven, Louvain, Belgium
Vermeersch, Pieter; Department of Laboratory of Laboratory Medicine, University Hospitals Leuven, Louvain, Belgium
Pottel, Hans; Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium
Mekahli, Djalila ; PKD Research Group, Department of Cellular and Molecular Medicine, KU Leuven, Louvain, Belgium. djalila.mekahli@uzleuven.be ; Department of Pediatric Nephrology, University Hospitals Leuven, Louvain, Belgium. djalila.mekahli@uzleuven.be
Language :
English
Title :
Low agreement between various eGFR formulae in pediatric and young adult ADPKD patients.
Publication date :
September 2023
Journal title :
Pediatric Nephrology
ISSN :
0931-041X
eISSN :
1432-198X
Publisher :
Springer Science and Business Media Deutschland GmbH, Germany
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